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Ershova A.I.
National Medical Research Center for Therapy and Preventive Medicine
Meshkov A.N.
Chazov National Medical Research Center of Cardiology;
National Medical Research Center for Therapy and Preventive Medicine
Mikhailina V.I.
National Medical Research Center for Therapy and Preventive Medicine
Blokhina A.V.
National Medical Research Center for Therapy and Preventive Medicine
Limonova A.S.
National Medical Research Center for Therapy and Preventive Medicine
Kopylova O.V.
National Medical Research Center for Therapy and Preventive Medicine
Gurevich V.S.
St. Petersburg State University;
Mechnikov North-Western State Medical University;
Sokolov Northwestern District Research Clinical Center
Urazgildeeva S.A.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Tregubov A.V.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Muzalevskaya M.V.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Sadykova D.I.
Kazan State Medical University
Galimova L.F.
Kazan State Medical University;
Children’s Republican Clinical Hospital
Kosmacheva E.D.
Research Institute — Ochapovsky Regional Clinical Hospital No. 1
Namitokov A.M.
Research Institute — Ochapovsky Regional Clinical Hospital No. 1
Galyavich A.S.
Kazan State Medical University
Kim Z.F.
Kazan State Medical University;
Kazan City Clinical Hospital No. 7
Vorobyov A.S.
District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»
Astrakhantseva I.D.
District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»
Compliance of patients with heterozygous familial hypercholesterolemia: 5-year follow-up of the renaissance registry
Journal: Russian Cardiology Bulletin. 2023;18(3): 35‑48
Views: 1306
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To cite this article:
Chubykina UV, Ezhov MV, Rozhkova TA, et al. . Compliance of patients with heterozygous familial hypercholesterolemia: 5-year follow-up of the renaissance registry. Russian Cardiology Bulletin.
2023;18(3):35‑48. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20231803135
To evaluate compliance of patients with heterozygous familial hypercholesterolemia (heFH) for 5-year period in the RENAISSANCE registry (Registry of patients with familial hypercholesterolemia and very high cardiovascular risk with insufficient effect of lipid-lowering therapy).
The RENAISSANCE registry is an open, national, observational study and includes FH patients. We analyzed atherosclerosis risk factors, history of CVD and adherence to LLT. Serum total cholesterol, triglycerides, high-density lipoprotein cholesterol were measured in all centers. LDL-C level was defined according to Friedewald formula.
The study included 2317 heterozygous FH patients (58% of female); 59% ones had high cardiovascular risk. Follow-up visits were conducted in 47% of subjects, median follow-up period was 24 months [11; 42]. Such patients had a definite heterozygous FH and hereditary history of CVD. They were younger and diagnosed with FH at an earlier age compared to patients without follow-up who had more common modifiable risk factors (p<0.05). In the group of high cardiovascular risk, 54% of patients received LLT, in the group with very high cardiovascular risk — 86%. The number of patients taking LLT increased from 59% to 78% throughout the follow-up period (statins at the highest dose — from 36% to 54%, combination with ezetimibe — 34% from 15%, PCSK9 inhibitors — 14% from 4% (p<0.001)). The target LDL-C level was reached by 13% of patients. Simulation analysis data showed that at least 92.5% of patients with heterozygous FH in the registry must receive combination of statins, ezetimibe and PCSK9 inhibitors for adequate LDL-C control.
A five-year follow-up of participants in the RENAISSANCE registry shows more common combinations of LLT. Nevertheless, it is insufficient for adequate LDL-C control.
Keywords:
Authors:
Ershova A.I.
National Medical Research Center for Therapy and Preventive Medicine
Meshkov A.N.
Chazov National Medical Research Center of Cardiology;
National Medical Research Center for Therapy and Preventive Medicine
Mikhailina V.I.
National Medical Research Center for Therapy and Preventive Medicine
Blokhina A.V.
National Medical Research Center for Therapy and Preventive Medicine
Limonova A.S.
National Medical Research Center for Therapy and Preventive Medicine
Kopylova O.V.
National Medical Research Center for Therapy and Preventive Medicine
Gurevich V.S.
St. Petersburg State University;
Mechnikov North-Western State Medical University;
Sokolov Northwestern District Research Clinical Center
Urazgildeeva S.A.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Tregubov A.V.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Muzalevskaya M.V.
St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center
Sadykova D.I.
Kazan State Medical University
Galimova L.F.
Kazan State Medical University;
Children’s Republican Clinical Hospital
Kosmacheva E.D.
Research Institute — Ochapovsky Regional Clinical Hospital No. 1
Namitokov A.M.
Research Institute — Ochapovsky Regional Clinical Hospital No. 1
Galyavich A.S.
Kazan State Medical University
Kim Z.F.
Kazan State Medical University;
Kazan City Clinical Hospital No. 7
Vorobyov A.S.
District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»
Astrakhantseva I.D.
District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»
Received:
19.04.2023
Accepted:
20.06.2023
List of references:
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