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Chubykina U.V.

Chazov National Medical Research Center of Cardiology

Ezhov M.V.

Chazov National Medical Research Center of Cardiology

Rozhkova T.A.

Chazov National Medical Research Center of Cardiology

Tamaeva B.M.

Chazov National Medical Research Center of Cardiology

Sokolov A.A.

Chazov National Medical Research Center of Cardiology

Ershova A.I.

National Medical Research Center for Therapy and Preventive Medicine

Meshkov A.N.

Chazov National Medical Research Center of Cardiology;
National Medical Research Center for Therapy and Preventive Medicine

Mikhailina V.I.

National Medical Research Center for Therapy and Preventive Medicine

Blokhina A.V.

National Medical Research Center for Therapy and Preventive Medicine

Limonova A.S.

National Medical Research Center for Therapy and Preventive Medicine

Kopylova O.V.

National Medical Research Center for Therapy and Preventive Medicine

Shaposhnik I.I.

South Ural State Medical University

Genkel V.V.

South Ural State Medical University

Gurevich V.S.

St. Petersburg State University;
Mechnikov North-Western State Medical University;
Sokolov Northwestern District Research Clinical Center

Urazgildeeva S.A.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Tregubov A.V.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Muzalevskaya M.V.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Voevoda M.I.

Institute of cytology and genetics

Timoshchenko O.V.

Institute of cytology and genetics

Shakhtshneider E.V.

Institute of cytology and genetics

Ragino Yu.I.

Institute of cytology and genetics

Sadykova D.I.

Kazan State Medical University

Slastnikova E.S.

Children’s Republican Clinical Hospital

Galimova L.F.

Kazan State Medical University;
Children’s Republican Clinical Hospital

Kosmacheva E.D.

Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Namitokov A.M.

Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Alieva A.S.

Almazov National Medical Research Center

Galyavich A.S.

Kazan State Medical University

Kim Z.F.

Kazan State Medical University;
Kazan City Clinical Hospital No. 7

Korneva V.A.

Petrozavodsk State University

Kuznetsova T.Yu.

Petrozavodsk State University

Filippov A.E.

MMC LLC;
St. Petersburg State University

Tuktarov A.M.

MMC LLC;
St. Petersburg State University

Vorobyov A.S.

District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»

Astrakhantseva I.D.

District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»

Bogdanov D.Yu.

Vladivostok City Clinical Hospital No. 1

Kachkovsky M.A.

Reaviz Medical University, REAVIZ Multi-field Hospital

Egorova A.V.

Samara City Polyclinic No. 1

Konstantinov V.O.

Hospital for War Veterans

Serebrenitskaya M.P.

Hospital for War Veterans

Zafiraki V.K.

Regional Clinical Hospital No. 2

Bizyaeva N.N.

Clinical Cardiology Dispensary

Androsyuk N.G.

Regional Cardiology Dispensary

Kiseleva M.A.

Regional Cardiology Dispensary

Grigorieva Yu.G.

Regional Cardiology Dispensary

Korennova O.Yu.

Omsk State Medical University

Yukhina Yu.E.

Omsk State Medical University

Devyatova M.D.

Yekaterinburg City Central Clinical Hospital No. 3

Isaeva A.V.

Yekaterinburg City Central Clinical Hospital No. 3

Ivanova O.N.

Bochkov Medical Genetic Research Center

Vasiliev P.A.

Bochkov Medical Genetic Research Center

Avdeeva I.V.

Penza State University

Oleinikov V.E.

Penza State University

Vorobieva Yu.A.

Altai Regional Cardiology Dispensary

Ermakova Yu.A.

Altai Regional Cardiology Dispensary

Mukha N.V.

Chita State Medical Academy

Zaitsev D.N.

Chita State Medical Academy

Vasilenko P.A.

Chita State Medical Academy

Zykov M.V.

Sochi City Hospital No. 4

Petelina T.I.

Tyumen Cardiology Research Center

Mikova E.V.

Tyumen Cardiology Research Center

Bednova S.E.

Kirov Military Medical Academy

Compliance of patients with heterozygous familial hypercholesterolemia: 5-year follow-up of the renaissance registry

Authors:

Chubykina U.V., Ezhov M.V., Rozhkova T.A., Tamaeva B.M., Sokolov A.A., Ershova A.I., Meshkov A.N., Mikhailina V.I., Blokhina A.V., Limonova A.S., Kopylova O.V., Shaposhnik I.I., Genkel V.V., Gurevich V.S., Urazgildeeva S.A., Tregubov A.V., Muzalevskaya M.V., Voevoda M.I., Timoshchenko O.V., Shakhtshneider E.V., Ragino Yu.I., Sadykova D.I., Slastnikova E.S., Galimova L.F., Kosmacheva E.D., Namitokov A.M., Alieva A.S., Galyavich A.S., Kim Z.F., Korneva V.A., Kuznetsova T.Yu., Filippov A.E., Tuktarov A.M., Vorobyov A.S., Astrakhantseva I.D., Bogdanov D.Yu., Kachkovsky M.A., Egorova A.V., Konstantinov V.O., Serebrenitskaya M.P., Zafiraki V.K., Bizyaeva N.N., Androsyuk N.G., Kiseleva M.A., Grigorieva Yu.G., Korennova O.Yu., Yukhina Yu.E., Devyatova M.D., Isaeva A.V., Ivanova O.N., Vasiliev P.A., Avdeeva I.V., Oleinikov V.E., Vorobieva Yu.A., Ermakova Yu.A., Mukha N.V., Zaitsev D.N., Vasilenko P.A., Zykov M.V., Petelina T.I., Mikova E.V., Bednova S.E.

More about the authors

Journal: Russian Cardiology Bulletin. 2023;18(3): 35‑48

DOI: 10.17116/Cardiobulletin20231803135

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Table of contents

COMPLIANCE OF PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: 5-YEAR FOLLOW-UP OF THE RENAISSANCE REGISTRY
COMPLIANCE OF PATIENTS WITH HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: 5-YEAR FOLLOW-UP OF THE RENAISSANCE REGISTRY

To cite this article:

Chubykina UV, Ezhov MV, Rozhkova TA, et al. . Compliance of patients with heterozygous familial hypercholesterolemia: 5-year follow-up of the renaissance registry. Russian Cardiology Bulletin. 2023;18(3):35‑48. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20231803135

Подписка 2025-2 (Russian Cardiology Bulletin)
 
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OBJECTIVE

To evaluate compliance of patients with heterozygous familial hypercholesterolemia (heFH) for 5-year period in the RENAISSANCE registry (Registry of patients with familial hypercholesterolemia and very high cardiovascular risk with insufficient effect of lipid-lowering therapy).

MATERIAL AND METHODS

The RENAISSANCE registry is an open, national, observational study and includes FH patients. We analyzed atherosclerosis risk factors, history of CVD and adherence to LLT. Serum total cholesterol, triglycerides, high-density lipoprotein cholesterol were measured in all centers. LDL-C level was defined according to Friedewald formula.

RESULTS

The study included 2317 heterozygous FH patients (58% of female); 59% ones had high cardiovascular risk. Follow-up visits were conducted in 47% of subjects, median follow-up period was 24 months [11; 42]. Such patients had a definite heterozygous FH and hereditary history of CVD. They were younger and diagnosed with FH at an earlier age compared to patients without follow-up who had more common modifiable risk factors (p<0.05). In the group of high cardiovascular risk, 54% of patients received LLT, in the group with very high cardiovascular risk — 86%. The number of patients taking LLT increased from 59% to 78% throughout the follow-up period (statins at the highest dose — from 36% to 54%, combination with ezetimibe — 34% from 15%, PCSK9 inhibitors — 14% from 4% (p<0.001)). The target LDL-C level was reached by 13% of patients. Simulation analysis data showed that at least 92.5% of patients with heterozygous FH in the registry must receive combination of statins, ezetimibe and PCSK9 inhibitors for adequate LDL-C control.

CONCLUSION

A five-year follow-up of participants in the RENAISSANCE registry shows more common combinations of LLT. Nevertheless, it is insufficient for adequate LDL-C control.

Keywords:

heterozygous familial hypercholesterolemia
registry
atherosclerotic cardiovascular diseases
lipid-lowering therapy

Authors:

Chubykina U.V.

Chazov National Medical Research Center of Cardiology

Ezhov M.V.

Chazov National Medical Research Center of Cardiology

Rozhkova T.A.

Chazov National Medical Research Center of Cardiology

Tamaeva B.M.

Chazov National Medical Research Center of Cardiology

Sokolov A.A.

Chazov National Medical Research Center of Cardiology

Ershova A.I.

National Medical Research Center for Therapy and Preventive Medicine

Meshkov A.N.

Chazov National Medical Research Center of Cardiology;
National Medical Research Center for Therapy and Preventive Medicine

Mikhailina V.I.

National Medical Research Center for Therapy and Preventive Medicine

Blokhina A.V.

National Medical Research Center for Therapy and Preventive Medicine

Limonova A.S.

National Medical Research Center for Therapy and Preventive Medicine

Kopylova O.V.

National Medical Research Center for Therapy and Preventive Medicine

Shaposhnik I.I.

South Ural State Medical University

Genkel V.V.

South Ural State Medical University

Gurevich V.S.

St. Petersburg State University;
Mechnikov North-Western State Medical University;
Sokolov Northwestern District Research Clinical Center

Urazgildeeva S.A.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Tregubov A.V.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Muzalevskaya M.V.

St. Petersburg State University;
Sokolov Northwestern District Research Clinical Center

Voevoda M.I.

Institute of cytology and genetics

Timoshchenko O.V.

Institute of cytology and genetics

Shakhtshneider E.V.

Institute of cytology and genetics

Ragino Yu.I.

Institute of cytology and genetics

Sadykova D.I.

Kazan State Medical University

Slastnikova E.S.

Children’s Republican Clinical Hospital

Galimova L.F.

Kazan State Medical University;
Children’s Republican Clinical Hospital

Kosmacheva E.D.

Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Namitokov A.M.

Research Institute — Ochapovsky Regional Clinical Hospital No. 1

Alieva A.S.

Almazov National Medical Research Center

Galyavich A.S.

Kazan State Medical University

Kim Z.F.

Kazan State Medical University;
Kazan City Clinical Hospital No. 7

Korneva V.A.

Petrozavodsk State University

Kuznetsova T.Yu.

Petrozavodsk State University

Filippov A.E.

MMC LLC;
St. Petersburg State University

Tuktarov A.M.

MMC LLC;
St. Petersburg State University

Vorobyov A.S.

District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»

Astrakhantseva I.D.

District Cardiology Dispensary «Center for Diagnostics and Cardiovascular Surgery»

Bogdanov D.Yu.

Vladivostok City Clinical Hospital No. 1

Kachkovsky M.A.

Reaviz Medical University, REAVIZ Multi-field Hospital

Egorova A.V.

Samara City Polyclinic No. 1

Konstantinov V.O.

Hospital for War Veterans

Serebrenitskaya M.P.

Hospital for War Veterans

Zafiraki V.K.

Regional Clinical Hospital No. 2

Bizyaeva N.N.

Clinical Cardiology Dispensary

Androsyuk N.G.

Regional Cardiology Dispensary

Kiseleva M.A.

Regional Cardiology Dispensary

Grigorieva Yu.G.

Regional Cardiology Dispensary

Korennova O.Yu.

Omsk State Medical University

Yukhina Yu.E.

Omsk State Medical University

Devyatova M.D.

Yekaterinburg City Central Clinical Hospital No. 3

Isaeva A.V.

Yekaterinburg City Central Clinical Hospital No. 3

Ivanova O.N.

Bochkov Medical Genetic Research Center

Vasiliev P.A.

Bochkov Medical Genetic Research Center

Avdeeva I.V.

Penza State University

Oleinikov V.E.

Penza State University

Vorobieva Yu.A.

Altai Regional Cardiology Dispensary

Ermakova Yu.A.

Altai Regional Cardiology Dispensary

Mukha N.V.

Chita State Medical Academy

Zaitsev D.N.

Chita State Medical Academy

Vasilenko P.A.

Chita State Medical Academy

Zykov M.V.

Sochi City Hospital No. 4

Petelina T.I.

Tyumen Cardiology Research Center

Mikova E.V.

Tyumen Cardiology Research Center

Bednova S.E.

Kirov Military Medical Academy

Received:

19.04.2023

Accepted:

20.06.2023

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The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
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