Prognostic significance of DAPT scale and D-Dimer level in patients treated with elective PCI

Komarov A.L.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Novikova E.S.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Dobrovol'skiĭ A.B.

Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia RF, Moskva

Yarovaya E.B.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation;
Lomonosov Moscow State University, Moscow, Russian Federation

Guskova E.V.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Samko A.N.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Panchenko E.P.

Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia RF, Moskva

Prognostic significance of DAPT scale and D-Dimer level in patients treated with elective PCI

Authors:

Komarov A.L., Novikova E.S., Dobrovol'skiĭ A.B., Yarovaya E.B., Guskova E.V., Samko A.N., Panchenko E.P.

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Journal: Russian Cardiology Bulletin. 2018;13(2): 39‑47

DOI: 10.17116/Cardiobulletin201813239

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Komarov AL, Novikova ES, Dobrovol'skiĭ AB, Yarovaya EB, Guskova EV, Samko AN, Panchenko EP. Prognostic significance of DAPT scale and D-Dimer level in patients treated with elective PCI. Russian Cardiology Bulletin. 2018;13(2):39‑47. (In Russ.)
https://doi.org/10.17116/Cardiobulletin201813239

Подписка 2025-2 (Russian Cardiology Bulletin)

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Aim. To study the association between DAPT score, haemostatic factor — D-dimer and prognosis of thrombotic and bleeding events in patients with stable coronary artery disease (CAD), receiving dual antiplatelet therapy (DAPT) after elective percutaneous coronary intervention (PCI). Маterial and methods. The study (2012—2013 years) included 188 patients with stable CAD after elective PCI on DAPT for 6—12 months after the procedure. Individual DAPT score was calculated in patients retrospectively. D-dimer level was assessed by ELISA method the day before PCI. The median of follow-up period was 651 days (min — 23 days and max — 1476 days). Registered thrombotic events: cardiovascular death, acute coronary syndrome, stroke/transient ischemic attack, thrombosis of peripheral arteries, pulmonary embolism. Bleeding events had been characterized by BARC-defined bleeding classification (Bleeding Academic Research consortium, 2011). Results. During the follow-up period incidence rate of thrombotic and bleeding events (BARC 2—5 type) was 15.4% and 12.2%, respectively. Among all patients, 100 (53.2%) patients had a high (≥2) DAPT score, 88 (46.8%) had a low (<2) DAPT score. High (≥2) DAPT score was associated with an increased risk of thrombotic events — OR 3.12 (95% CI 1.1—8.3, p=0.01). D-dimer level had exponential dependence on age among the studied patients. High D-dimer level (≥292 ng/ml for patients <65 years, ≥610 ng/ml for patients ≥65 years) was associated with thrombotic events after DAPT discontinuation — OR 2.6 (95%CI 1.0—6.9, р=0.04).

Keywords:

thrombotic and bleeding events

DAPT score

D-dimer

elective PCI

Authors:

Komarov A.L.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Novikova E.S.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Dobrovol'skiĭ A.B.

Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia RF, Moskva

Yarovaya E.B.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation;
Lomonosov Moscow State University, Moscow, Russian Federation

Guskova E.V.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Samko A.N.

Russian Cardiology Research and Production Complex of the Ministry of Healthcare, Moscow, Russian Federation

Panchenko E.P.

Rossiĭskiĭ kardiologicheskiĭ nauchno-proizvodstvennyĭ kompleks Minzdravsotsrazvitiia RF, Moskva

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