Objective. The aim of this study is assessment of transcatheter aortic valve replacement outcomes in patients with horizontal aortic root. Materials and methods. 35 patients who underwent transcatheter aortic valve implantation (TAVI) in cardiovascular department of cardiology research center from 2010 to 2016 were included in the study. Horizontal aortic root is determined by computer tomography and angiography Technical knockout of procedure, hemodynamic indices of prosthesis and postoperative complications were assessed. Results. Mean age of patient was 78±5,7 years. The vast majority of them had 3 or 4 functional class of heart failure according NYHA More than a half of patients were in a history of cardiac surgery Mean EuroScore was 17,5±5,9%. The self-expending and balloon-expending endoprosthesis were implanted in 20 and 15 cases respectively. Hemodynamic indices of prosthesis were adequate in all cases There were 2 atrioventricular blocks, 2 paraprosthetic leaks, 2 prosthesis postdilatations, 1 bioprosthesis reimplantation and 4 cases of contrast induced nephropathy in postoperative period. Conclusion. Relevant experience of TAVI allows to perform this procedure in patients with horizontal aorta without complications