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Ilyukhin E.A.

Surgical clinic Medalp

Kurginyan Kh.M.

Laser surgery clinic “Varicose No”

Kovalenko K.E.

Laser surgery clinic “Varicose No”

Norvardyan A.M.

Laser surgery clinic “Varicose No”

Abukhamdan A.S.

Laser surgery clinic “Varicose No”

Gevorgyan A.A.

Laser surgery clinic “Varicose No”

Kartoev I.R.

Laser surgery clinic “Varicose No”

Impact of Micronized Purified Flavonoid Fraction on Subjective Symptoms After Endovenous Laser Varicose Vein Surgery: the Protocol of the Randomized Controlled Trial DEMO

Authors:

Ilyukhin E.A., Kurginyan Kh.M., Kovalenko K.E., Norvardyan A.M., Abukhamdan A.S., Gevorgyan A.A., Kartoev I.R.

More about the authors

Journal: Journal of Venous Disorders. 2023;17(4): 338‑342

DOI: 10.17116/flebo202317041338

Views: 777

Downloaded: 12

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Table of contents

To cite this article:

Ilyukhin EA, Kurginyan KhM, Kovalenko KE, Norvardyan AM, Abukhamdan AS, Gevorgyan AA, Kartoev IR. Impact of Micronized Purified Flavonoid Fraction on Subjective Symptoms After Endovenous Laser Varicose Vein Surgery: the Protocol of the Randomized Controlled Trial DEMO. Journal of Venous Disorders. 2023;17(4):338‑342. (In Russ.)
https://doi.org/10.17116/flebo202317041338

Подписка 2025 (Journal of Venous Disorders)
 
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Micronized purified flavonoid fraction (MPFF) appears to be a perspective drug for the management of venous symptoms after minimally invasive varicose vein surgery.

OBJECTIVE

To evaluate the effect of MPFF on subjective symptoms of chronic venous disease (CVD) after endovenous laser varicose vein surgery and removal of varicose tributaries.

MATERIAL AND METHODS

A multiple-center open-label randomized controlled trial is scheduled. The study was registered in the Register of Chronic Venous Diseases of the Association of Phlebologists (ID RRT_CVD 1.016). The trial was designed in accordance with the CONSORT standards for randomized trials. Study endpoints: total sum score of symptoms (main outcome), score of certain symptoms, number of CVD symptoms in one patient between the 1st and 2nd visits with an interval of 2 weeks after surgery.

Keywords:

MPFF
symptoms
CVD
endovenous laser obliteration (EVLO)

Authors:

Ilyukhin E.A.

Surgical clinic Medalp

Kurginyan Kh.M.

Laser surgery clinic “Varicose No”

Kovalenko K.E.

Laser surgery clinic “Varicose No”

Norvardyan A.M.

Laser surgery clinic “Varicose No”

Abukhamdan A.S.

Laser surgery clinic “Varicose No”

Gevorgyan A.A.

Laser surgery clinic “Varicose No”

Kartoev I.R.

Laser surgery clinic “Varicose No”

Received:

09.11.2023

Accepted:

16.11.2023

List of references:

  1. Perrin M, Eklof B, VAN Rij A, Labropoulos N, Vasquez M, Nicolaides A, Blattler W, Bouhassira D, Bouskela E, Carpentier P, Darvall K, De Maeseneer M, Flour M, Guex JJ, Hamel-Desnos C, Kakkos S, Launois R, Lugli M, Maleti O, Mansilha A, NEGLéN P, Rabe E, Shaydakov E. Venous symptoms: the SYM Vein Consensus statement developed under the auspices of the European Venous Forum. Int Angiol. 2016;35(4):374-398. 
  2. Zolotukhin IA, Seliverstov EI, Shevtsov YuN, Avakiants IP, Nikishkov AI, Tatarintsev AM, Kirienko AI. Prevalence of Chronic Venous Disease: Results of Population Based Epidemiological Study. Flebologiya. 2016;10(3):119-125. (In Russ.). https://doi.org/10.17116/flebo2016103119-125
  3. Zolotukhin IA, Seliverstov EI, Shevtsov YN, Avakiants IP, Tatarintsev AM, Kirienko AI, Zolotukhin IA, Seliverstov EI, Shevtsov YN, Avakiants IP. Risk factors for venous symptoms in Russian patients with chronic venous disease Risk factors for venous symptoms in Russian patients with chronic. Curr Med Res Opin Taylor & Francis. 2019;35(9):1583-1587.
  4. Klitfod L, Sillesen H, Jensen LP. Patients and physicians agree only partially in symptoms and clinical findings before and after treatment for varicose veins. Phlebology. 2018;33(2):115-121. 
  5. Kakkos SK, Nicolaides AN. Efficacy of micronized purified flavonoid fraction (Daflon®) on improving individual symptoms, signs and quality of life in patients with chronic venous disease: A systematic review and meta-analysis of randomized double-blind placebo-controlled trials. Int Angiol Italy. 2018;37(2):143-154. 
  6. Bush R, Comerota A, Meissner M, Raffetto JD, Hahn SR, Freeman K. Recommendations for the medical management of chronic venous disease: The role of Micronized Purified Flavanoid Fraction (MPFF). Phlebology. 2017;32(1 Suppl):3-19. 
  7. Lobastov KV. Impact of Microcirculatory Disorders on the Symptoms of Chronic Venous Disease and Their Pharmacological Correction. Flebologiya. 2020;14(1):30-39. (In Russ.). https://doi.org/10.17116/flebo20201401130
  8. Instructions for the medical use of the drug Detravenol. [Electronic resource]. 2023. (In Russ.). Accessed October 08, 2023. https://grls.minzdrav.gov.ru/Grls_View_v2.aspx?routingGuid=caf9ce72-2936-427d-bfff-7387f09f5f81
  9. The Russian Phlebological Association. Varicose veins of the lower extremities [Electronic resource]. 2021. (In Russ.). Accessed October 08, 2023. https://cr.minzdrav.gov.ru/recomend/680_1
  10. De Maeseneer MG, Kakkos SK, Aherne T, Baekgaard N, Black S, Blomgren L, Giannoukas A, Gohel M, de Graaf R, Hamel-Desnos C, Jawien A, Jaworucka-Kaczorowska A, Lattimer CR, Mosti G, Noppeney T, van Rijn MJ, Stansby G, Esvs Guidelines Committee, Kolh P, Bastos Goncalves F, Chakfé N, Coscas R, de Borst GJ, Dias NV, Hinchliffe RJ, Koncar IB, Lindholt JS, Trimarchi S, Tulamo R, Twine CP, Vermassen F, Wanhainen A, Document Reviewers, Björck M, Labropoulos N, Lurie F, Mansilha A, Nyamekye IK, Ramirez Ortega M, Ulloa JH, Urbanek T, van Rij AM, Vuylsteke ME. Editor’s Choice ‒ European Society for Vascular Surgery (ESVS) 2022 Clinical Practice Guidelines on the Management of Chronic Venous Disease of the Lower Limbs. Eur J Vasc Endovasc Surg. 2022;63(2):184-267. 
  11. Kamaev AA, Bulatov VL, Vakhratyan PE, Volkov AM, Volkov AS, Gavrilov EK, Golovina VI, Efremova OI, Ivanov OO, Ilyukhin EA, Katorkin SE, Konchugova TV, Kravtsov PF, Maksimov SV, Mzhavanadze ND, Pikhanova ZhM, Pryadko SI, Smirnov AA, Sushkov SA, Chabbarov RG, Shimanko AI, Yakushkin SN, Aphanova TV, Derkachev SN, Zolotukhin IA, Kalinin RE, Kirienko AI, Kulchitskaya DB, Pelevin AV, Petrikov AS, Rachin AP, Seliverstov EI, Stoyko YuM, Suchkov IA. Varicose Veins. Recommendations of the Association of Phlebologists of Russia. Flebologiya. 2022;16(1):41-108. (In Russ.). https://doi.org/10.17116/flebo20221601141
  12. Russian Registry of Treatment of Chronic Venous Disease (RRT CVD). DEMO: RCT MOFF Detravenol in the postoperative period [Electronic resource]. 2023. (In Russ.). Accessed November 09, 2023. https://www.venousregistry.org/index.php?f=1&id=108

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