The Role of the Acquired Risk Factors in the Development of Venous Thromboembolism in the Women of Reproductive Age Carrying Factor V Leiden

Nikolaeva M.G.; Momot K.A.; Yasafova N.N.; Momot A.P.; Khorev N.G.

doi:https://doi.org/10.17116/flebo2018123101

Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Momot K.A.

Altai Regional Clinical Hospital, Barnaul, Russia

Yasafova N.N.

Altai Regional Clinical Hospital, Barnaul, Russia

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Khorev N.G.

Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Barnaul;
Otdelencheskaia klinicheskaia bol'nitsa st. Barnaul

The Role of the Acquired Risk Factors in the Development of Venous Thromboembolism in the Women of Reproductive Age Carrying Factor V Leiden

Authors:

Nikolaeva M.G., Momot K.A., Yasafova N.N., Momot A.P., Khorev N.G.

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Journal: Journal of Venous Disorders. 2018;12(3): 101‑108

DOI: 10.17116/flebo2018123101

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Nikolaeva MG, Momot KA, Yasafova NN, Momot AP, Khorev NG. The Role of the Acquired Risk Factors in the Development of Venous Thromboembolism in the Women of Reproductive Age Carrying Factor V Leiden. Journal of Venous Disorders. 2018;12(3):101‑108. (In Russ.)
https://doi.org/10.17116/flebo2018123101

Подписка 2026 Флебология (Journal of Venous Disorders)

Использование инфографики авторами научных работ

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Abstract:

Aim — the objective of the present study was to reveal and evaluate the association between the combination of the acquired thrombogenic factors with primary acquired activated protein C (APC) resistance due to the heterozygous carriage of FVL(1691)GA mutation and venous thromboembolism. Material and methods. The present prospective cohort study involved 1100 women of reproductive age. Two cohorts were compared: the study group of 500 patients with FVL(1691)GA genotype and the control group of 600 women with FVL(1691)GG genotype. Results. The study has demonstrated that carriage of the FVL(1691)GA mutation is associated with the development of venous thromboembolism (VTE); no such association was documented for the women with the normozygous FVL(1691)GG genotype (RR=9.3; p<0.0001). The highest frequency of primary VTE events was found in women receiving hormone contraception (RR=9.2; p<0.0001). Venous thromboembolism is more likely to occur in FVL(1691)GA women with excessive body weight (BMI≥25) (RR=1.5; p=0.0005); hypertensive disorders (RR=2.3; p<0.0001); varicose veins in the lower extremities (RR=1.7; p<0.0001) and/or combinations of these conditions (RR=4.5; p<0.0001). In all the cases of VTE the APC resistance normalized ratio (NR) index was ≤0.49, with no episodes of VTE associated with NR ≥0.5. Conclusion. The combination of additional risk factors in the carriers of the FVL(1691)GA contributes to the development of venous thromboembolism events with pronounced APC resistance.

Keywords:

factor V Leiden mutation

FVL(1691)GA genotype

thromboembolic complications

APC resistance

Authors:

Nikolaeva M.G.

Obstetrics and Gynecology Department with the course of Supplementary Vocational Education in FSBEI of Higher Education «Altai State Medical University» Barnaul, Russia

Momot K.A.

Altai Regional Clinical Hospital, Barnaul, Russia

Yasafova N.N.

Altai Regional Clinical Hospital, Barnaul, Russia

Momot A.P.

Altai Branch of the FSBI «National Research Center for Hematology», Barnaul, Russia

Khorev N.G.

Altaĭskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Barnaul;
Otdelencheskaia klinicheskaia bol'nitsa st. Barnaul

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References:

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