Objective. To evaluate the state of great saphenous vein (GSV) in the patients presenting with the symptoms of phlebopathy in the absence of the apparent manifestations of primary varicosis. Another objective was to assess the possibility of elimination of temporary refluxe by means of pharmacotherapy. Material and methods. The present study included 41 women at the age from 21 to 57 years presenting with the symptoms of phlebopathy. Duplex scanning (DS) was performed twice: in the morning (before 10 a.m.) and in the evening (after 6 p.m.). The following parameters were measured: 1) diameter of the great saphenous vein in the inguinal region and 2) the increment of the GSV diameter by the evening (the orthostatic gradient). Results. Twenty six patients developed reflux within the great saphenous vein after 6 p.m. when the GSV diameter was 6.33 mm (0.95% CI; 4.50—8.00 mm) and the orthostatic gradient 0.82 mm (0.95% CI; 0.30—1.20 mm). These values were higher (p<0.05) than in the subgroup of patients without reflux (n=15) in whom the GSV diameter was 5.45 mm (0.95% CI; 4.00—6.50 mm) and the orthostatic gradient 0.42 mm (0.95% CI; 0.10—0.65 mm). The patients with transient reflux were given the two-month course of phlebotropic therapy. This treatment resulted in the disappearance of temporary reflux in 22 patients. In the evening, the GSV diameter decreased from 6.33 mm (0.95% CI; 4.50—8.00 mm) to 5.50 mm (0.95% CI; 1.10—7.00 mm) and the orthostatic gradient from 0.82 mm (0.95% CI; 0.30 – 1.20 mm) to 0.37 (0.95% CI; 0.10—0.70 mm) (p<0.0001). Conclusion. The patients presenting with the clinical manifestations of orthostasis-dependent phlebopathy and subjected to long-standing orthostatic load are likely to develop temporary (transient) reflux within the great saphenous vein. Duplex scanning with the use of the day-time orthostatic test makes it possible to detect transient GSV reflux. The phlebotropic treatment promoted the elimination of temporary reflux within the great saphenous vein.