Aim — the objective of the present study was to elucidate specific ultrasound characteristics of the changes in the venous system of the opiate drug users. Material and methods. A total of 150 patients with the history of intravenous drug (ID) abuse were available for the examination. They were divided into two groups. Group 1 was comprised of the subjects who had used drugs up the onset of the study (n=40; 23 men and 17 women aged from 21 to 44 (mean 31) years). Group 2 consisted of 110 subjects in the state of remission from the drug dependence (24 men and 86 women at the age from 24 to 59 (mean 37) years). All the patients were involved in the ultrasound study of the internal organs and the peripheral vascular bed. Results. It was shown that the patients using the intravenous drugs during a period up to 2 years do not suffer vein deformation with the exception of the narrowing of the left median cubital vein. Venous deformation in the form of a “strand of beads” develops after 2—5 years of drug abuse and is sometimes irreversible. Venous thrombosis and chronic venous insufficiency only rarely occur in the subjects using opiate drugs during 2—5 years. The patients ceasing to use a drug experience normalization of the narrowed vein lumen within 5—10 years after the onset of remission. At the same time, the majority of the patients using ID during 5 to 10 years or longer suffer the irreversible changes in the lymphovenous system that clinically manifest themselves as puffy hand syndrome. Supravenous «pothole» deformations are formed as soon as 1—2 years after the onset of ID abuse. The use of intravenous dugs during 10 years or longer results in persistent irreversible hyperplasia of the lymph nodes. Vemous obstruction most frequently occurs in the patients using intravenous oiates during 10 years or more. Conclusion. The majority of the patients using intravenous opiate drugs develop a combination of pathological changes in the venous system.