The present article summarizes the first experience with sclerotherapy of dilated superficial periorbital veins (SPOV). A total of 27 female patients aged from 19 to 57 years underwent SPOV sclerotherapy for aesthetic reasons between 2004 and 2009. A 1% polydocanol and 0.5% sodium tetradecyl sulfate solution were used as sclerosing agents. They were administered both as native (solid) preparations and as microfoam. All interventions gave good aesthetic and functional results. Neither adverse events nor ohpthelmological and neurologic complications were documented. The authors conclude that sclerotherapy provides an efficacious and safe tool for the extirpation of dilated superficial periorbital veins.