Goal. Possibility study of intravenous drip-feed octreotide 600 mg / ml with ERCPG, endoscopic interventions on the common bile duct and major duodenal papilla, determination of capacity medicated prevention and risk identification for the development of APPP. Material and methods. The clinical randomized prospective study was carried out in accordance with the principles of scientific medical research laid down in the Helsinki Declaration of the World Medical Association in 1989 and Order No. 266 of the Ministry of Health of the Russian Federation from June 19, 2003, approved by the local ethical committee. The results of endoscopic interventions MDP and CBD in 150 patients with complicated form of cholelithiasis, who underwent inpatient treatment in the surgical department of FMBA of Russia from September 2011 to September 2016, were analyzed. Results. In I group the endoscopic interventions were performed: ERCPG + PST and lithoextraction in 54 (75%) patients; ERCPG + PST and internal endoprosthetics of CBD in 7 (9.7%) patients; ERCPG + PST and external nasibiliary drainage of CBD — in 11 (15.3%) patients. In II group, these endoscopic manipulations were performed in 56 (71.8%), 8 (10.3%) and 14 (17.9%) patients, respectively. Difficulties with cannulation of MDP were noted in 24 (33.3%) patients in group I and 28 (35.9%) in group II, contrasting of the Virsung duct was recorded in 16 (22.2%) and 18 (23.1%) patients, respectively. After ERCPG and other endoscopic manipulations, APPP developed in 8 (11.1%) patients, transient amylasemia in 12 (16.7%) in group I; In group II, in 13 (16.7%) and in 15 (19.2%) patients, respectively. In the remaining patients, I (72.2%) and II (64.1%) groups clinical and laboratory manifestations of APPP and transient amylasemia were not registered. There were no lethal outcomes. Conclusions. The carrying out of ERCPG, PST and other endoscopic manipulations requires special measures to prevent the development of APMP. It was proved that intravenous dropping of Octreotide 600 µg/day in order to prevent the development of APMP due to endoscopic interventions on MDP and CBD is more effective and convenient than the traditional form of its use. The risk factors for the development of APMP after ERCPG and other endoscopic manipulations on the MDP and CBD are the young age of the patient, difficulties encountered in during cannulation of MDP, atypical PST, the introduction of contrast in the Virsung duct.