Goals. Evaluation of the surgical and technological aspects for using the ELED, ELD+, minilaparoscopic technologies in the treatment of gallstone disease. Methods. In the clinic of surgical diseases of pediatric and dental faculties VolgGMU from 2011 to 2016 have been studied a prospective cohort controlled of the case histories 538 patients with various forms of GSD, divided into 4 groups according to the variant LHE. Completed 176 TLHE, 211 operations using ELD+ technology, 91 operations using ELD technology, 60 CMLНЕ. Results. Direction of the ELD+, ELD and CMLHE technologies statistically does not affect to the duration of LHE, compared with TLHE (p> 0.05). The smallest average periods of postoperative inpatient stay in hospital after LHE were revealed in HKH and OKH in the CMLНЕ group, in OOKH in the ELD+ group. The differences in obtained results, as can be seen, were statistically significant in all study groups, which makes it possible to recommend their application in appropriate clinical situations. The best indicators of a decrease in the intensity of pain in the early postoperative period in HKH were achieved in the group of ELD and CMLE (p1 <0.05, p2 <0.05, p3> 0.05), with OKH — in all groups of ELD+, ELD , КМЛХЭ in comparison with ТЛХЭ (р1 <0,05; р2> 0,05; р3> 0,05); In the case of OCDS in the group ELD+ (p1 <0.05), where p1, p2, p3 — indices of the statistical significance research results in comparison with the groups TLHE, ELD+ and ELD, respectively, considering the sample data distribution in according to the normal law. Conclusion. The results of this study allow us to consider the decrease operational access traumatize , by using minimally invasive technologies in the treatment of patients with GSD, a natural and evolutionally justified stage in the development of endoscopic surgery. Demand for special equipment and tools for the LHE using the ELD, ELD+ and minilaparoscopy technologies, their high cost, as well as difficulties in mastering the technique of surgical intervention, in our opinion, are fully compensated by a reduction in the costs of treatment and preventive facilities related to the length of patients hospitalization, their early rehabilitation, a statistically proven reduction intensity of the pain syndrome in the early postoperative period. Considering the absence of statistically significant differences in the duration of LHE on any of the minimally invasive technologies that we applied, as well as the possibility of performing combined operations on abdominal and retroperitoneal organs, we consider it advisable to continue the development of a strategy for minimizing laparoscopic access in patients suffering from both chronic and acute calculous cholecystitis.