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Kaibysheva V.O.
N.I. Pirogov Russian National Research Medical University, Moscow, Russia;
City Clinical Hospital №31, Moscow, Russia
Mikhaleva L.M.
Research Institute of Human Morphology, Moscow, Russia
Vidyaeva N.S.
Yaroslavl Regional Clinical Oncological Hospital, Yaroslavl, Russia
Galkova Z.V.
Research Laboratory of Surgical Gastroenterology and Endoscopy based at the Municipal Clinical Hospital No 31, N.I. Pirogov Russian National Research Medical University, Moscow
Ilchishina T.A.
«SM-Klinika multi-field medical holding, St. Petersburg, Russia
Pechnikova V.V.
Pirogov Russian National Research Medical University, Moscow, Russia
Nikonov E.L.
FGBU "Poliklinika #1" Upravleniia delami Prezidenta RF
Shapoval’yants S.G.
Department of Hospital Surgery №2 with the research laboratory of surgical gastroenterology and endoscopy, N.I. Pirogov Russian National Research Medical University, Moscow
Eosinophilic esophagitis: current view on the problem and own clinical observations (in Russian only)
Journal: Russian Journal of Evidence-Based Gastroenterology. 2019;8(1): 58‑83
Views: 25933
Downloaded: 964
To cite this article:
Kaibysheva VO, Kashin SV, Mikhaleva LM, et al. . Eosinophilic esophagitis: current view on the problem and own clinical observations (in Russian only). Russian Journal of Evidence-Based Gastroenterology.
2019;8(1):58‑83. (In Russ., In Engl.)
https://doi.org/10.17116/dokgastro2019801158
Aim — to present current aspects of the etiology, pathogenesis, diagnosis and treatment of eosinophilic esophagitis (EoE). Main statements. Study of EoE has reached qualitatively new level in recent years: large randomized controlled trials and systematic reviews have been performed and published, key points of EoE etiopathogenesis have been revised. Today, the relationship between EoE and specific antigens is being questioned, whereas genetically determined impairment of barrier function of the esophagus and susceptibility to immune response through the T-helper cells type 2 activation are recognized as key factors in pathogenesis of the disease. Differential diagnosis of EoE with gastroesophageal reflux disease is not advisable because this pathology additionally aggravates course of eosinophilic esophagitis while high doses of proton pump inhibitors is the main aspect of EoE treatment. The concept of esophageal eosinophilia resolved on the background of proton pump inhibitors administration is recognized as erroneous. Conclusion. Eoeinophilic esophagitis is a chronic, immune-mediated, inflammatory disease of the esophagus. Diagnosis of EoE is based on characteristic clinical picture of esophageal dysfunction (dysphagia) combined with histological data of eosinophilic infiltration of esophageal mucosa. Basic therapy of eosinophilic esophagitis includes dietary restrictions, proton pump inhibitors and topical corticosteroids.
Authors:
Kaibysheva V.O.
N.I. Pirogov Russian National Research Medical University, Moscow, Russia;
City Clinical Hospital №31, Moscow, Russia
Mikhaleva L.M.
Research Institute of Human Morphology, Moscow, Russia
Vidyaeva N.S.
Yaroslavl Regional Clinical Oncological Hospital, Yaroslavl, Russia
Galkova Z.V.
Research Laboratory of Surgical Gastroenterology and Endoscopy based at the Municipal Clinical Hospital No 31, N.I. Pirogov Russian National Research Medical University, Moscow
Ilchishina T.A.
«SM-Klinika multi-field medical holding, St. Petersburg, Russia
Pechnikova V.V.
Pirogov Russian National Research Medical University, Moscow, Russia
Nikonov E.L.
FGBU "Poliklinika #1" Upravleniia delami Prezidenta RF
Shapoval’yants S.G.
Department of Hospital Surgery №2 with the research laboratory of surgical gastroenterology and endoscopy, N.I. Pirogov Russian National Research Medical University, Moscow
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