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Tsaregorodtseva A.D.

Dzhanelidze St. Petersburg Research Institute of Emergency Care

Tikhonova Yu.A.

Pavlov First Saint Petersburg State Medical University

Shishkina A.A.

Pavlov First St. Petersburg State Medical University

Smirnov A.S.

Pavlov First St. Petersburg State Medical University

Arnautov A.V.

Pavlov First St. Petersburg State Medical University

Nikulina K.A.

Pavlov First St. Petersburg State Medical University

Reva S.A.

Pavlov First St. Petersburg State Medical University

Petrov S.B.

Pavlov First St. Petersburg State Medical University

Musonova A.K.

Pavlov First St. Petersburg State Medical University

Nazarov V.D.

Pavlov First St. Petersburg State Medical University

Rybakova M.G.

Academician I.P. Pavlov First St. Petersburg State Medical University

Seminoma of undescended testis in a patient with false hermaphroditism

Authors:

Tsaregorodtseva A.D., Tikhonova Yu.A., Shishkina A.A., Smirnov A.S., Arnautov A.V., Nikulina K.A., Reva S.A., Petrov S.B., Musonova A.K., Nazarov V.D., Rybakova M.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(4): 48‑53

DOI: 10.17116/patol20258704148

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Table of contents

SEMINOMA OF UNDESCENDED TESTIS IN A PATIENT WITH FALSE HERMAPHRODITISM
SEMINOMA OF UNDESCENDED TESTIS IN A PATIENT WITH FALSE HERMAPHRODITISM

To cite this article:

Tsaregorodtseva AD, Tikhonova YuA, Shishkina AA, et al. . Seminoma of undescended testis in a patient with false hermaphroditism. Russian Journal of Archive of Pathology. 2025;87(4):48‑53. (In Russ.)
https://doi.org/10.17116/patol20258704148

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Disorders of sex development or hermaphroditism are a condition associated with a discrepancy between genetic, gonadal, and phenotypic sex. Persistent Müllerian duct syndrome (PMDS) is a rare form of male pseudohermaphroditism. Typical features are cryptorchidism and the presence of underdeveloped fallopian tubes, uterus or upper vagina in a male with karyotype 46, XY. Over the past 50 years, about 200 cases of persistent Müllerian duct syndrome have been reported. The article describes an observation of a 33-year-old patient with bilateral cryptorchidism, testicular neoplasm, and false hermaphroditism revealed during the examination of surgical material. Macroscopic and microscopic pictures are presented, including those using immunohistochemical methods. The results of a molecular genetic study of the surgical material are given. After all the examinations, the patient was diagnosed with: Typical seminoma of the right undescended testicle, pT2. False hermaphroditism,

Keywords:

false hermaphroditism
seminoma
cryptorchidism
persistent Müllerian duct syndrome

Authors:

Tsaregorodtseva A.D.

Dzhanelidze St. Petersburg Research Institute of Emergency Care

Tikhonova Yu.A.

Pavlov First Saint Petersburg State Medical University

Shishkina A.A.

Pavlov First St. Petersburg State Medical University

Smirnov A.S.

Pavlov First St. Petersburg State Medical University

Arnautov A.V.

Pavlov First St. Petersburg State Medical University

Nikulina K.A.

Pavlov First St. Petersburg State Medical University

Reva S.A.

Pavlov First St. Petersburg State Medical University

Petrov S.B.

Pavlov First St. Petersburg State Medical University

Musonova A.K.

Pavlov First St. Petersburg State Medical University

Nazarov V.D.

Pavlov First St. Petersburg State Medical University

Rybakova M.G.

Academician I.P. Pavlov First St. Petersburg State Medical University

Received:

03.03.2025

Accepted:

29.04.2025

Close metadata

References:

  1. Kalinchenko NYu, Tyul’pakov AN. Novaya klassifikatsiya zabolevanii, svyazannykh s narusheniem formirovaniya pola. Obsuzhdeniye mezhdunarodnogo konsensusa po peresmotru terminologii i klassifikatsii germafroditizma. Vestnik Reproduktivnogo Zdorov’ya. 2008;(3-4):48-51. (In Russ.). https://doi.org/10.14341/brh20083-448-51
  2. Renu D, Rao BG, Ranganath K, Namitha. Persistent Mullerian duct syndrome. Indian J Radiol Imaging. 2010;20(1):72-74.  https://doi.org/10.4103/0971-3026.59761
  3. Prakash N, Khurana A, Narula B. Persistent Müllerian duct syndrome. Indian J Pathol Microbiol. 2009;52(4):546-548.  https://doi.org/10.4103/0377-4929.56160
  4. Al-Hussain T. Disorders of sexual differentiation. PathologyOutlines.com website. Available at: https://www.pathologyoutlines.com/topic/testisdisordersofsexualdiff.html(AccessedFebruary12th,2024)
  5. Shinmura Y, Yokoi T, Tsutsui Y. A case of clear cell adenocarcinoma of the müllerian duct in persistent müllerian duct syndrome: the first reported case. Am J Surg Pathol. 2002;26(9):1231-1234. https://doi.org/10.1097/00000478-200209000-00014
  6. Aboutorabi R, Zadeh B, Rajabian R. Gynecomastia secondary to choriocarcinoma in a man with persistant Mullerian duct. Int J Endocrinol Metab. 2005;3(3):140-142. 
  7. Farikullah J, Ehtisham S, Nappo S, Patel L. Hennayake S. Persistent Müllerian duct syndrome: lessons learned from managing a series of eight patients over a 10-year period and review of literature regarding malignant risk from the Müllerian remnants. BJU Int. 2012;110(11 Pt. C):E1084-E1089. https://doi.org/10.1111/j.1464-410X.2012.11184.x
  8. Suspitsyn EN. Molekulyarnaya diagnostika nasledstvennykh zabolevanii, assotsiirovannykh s povyshennym riskom vozniknoveniya opukholei. Spetsial’nost’ 31.60.00. Diss. St. Petersburg; 2022. 277p. (In Russ.).
  9. Timoshevskii VA, Lebedev IN. Molekulyarnye metody bystrogo kariotipirovaniya v praktike prenatal’noi diagnostiki klinicheski znachimykh aneuploidii. Molekulyarno-biologicheskie tekhnologii v meditsinskoi praktike. Novosibirsk: Al’fa Vista N; 2009;(Issue 13):293-304. (In Russ.).
  10. Mitsui J, Ishiura H, Tsuji S. DNA sequencing and other methods of exonic and genomic analyses. In: Rosenberg’s molecular and genetic basis of neurological and psychiatric disease. 5th ed. 2014: 77-85. 
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