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Tertychnyy A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pachuashvili N.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Protsenko D.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Avraamova S.T.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Nagornaya D.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pavlov P.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kiryukhin A.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Fedorenko A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pyloric gland adenoma — a rare tumor of the upper gastrointestinal tract with a high risk of malignancy

Authors:

Tertychnyy A.S., Pachuashvili N.V., Protsenko D.D., Avraamova S.T., Nagornaya D.P., Pavlov P.V., Kiryukhin A.P., Fedorenko A.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(2): 30‑36

DOI: 10.17116/patol20248602130

Read: 2086 times

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Table of contents

PYLORIC GLAND ADENOMA — A RARE TUMOR OF THE UPPER GASTROINTESTINAL TRACT WITH A HIGH RISK OF MALIGNANCY
PYLORIC GLAND ADENOMA — A RARE TUMOR OF THE UPPER GASTROINTESTINAL TRACT WITH A HIGH RISK OF MALIGNANCY

To cite this article:

Tertychnyy AS, Pachuashvili NV, Protsenko DD, et al. . Pyloric gland adenoma — a rare tumor of the upper gastrointestinal tract with a high risk of malignancy. Russian Journal of Archive of Pathology. 2024;86(2):30‑36. (In Russ.)
https://doi.org/10.17116/patol20248602130

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Pyloric gland adenomas (PGA) are rare neoplasms of the gastrointestinal tract. According to the literature, these lesions may be underdiagnosed, and their true frequency of occurrence is underestimated.

OBJECTIVE

Clinical and morphological analysis of eight PGA cases of the upper gastrointestinal tract.

MATERIAL AND METHODS

The study included 8 cases of detection of PGA. In 7 out of 8 cases, the tumor was diagnosed by examining endoscopic biopsies, in 1 case, PGA was an accidental finding in the surgical material after proximal gastric resection.

RESULTS

6 out of 8 patients were female, the median age was 65 years (minimum 36 years and maximum 78 years). In 6 cases, PDA was localized in the stomach, in 1 — in the esophagus and in 1 — in the duodenum The size of the tumors ranged from 0.6 cm to 7.5 cm. 4 out of 6 stomach tumors appeared on the background of confirmed autoimmune gastritis, 1 — on the background of lymphocytic gastritis. 4 tumors were found in the body of the stomach, 1 — in the cardia, 1 — in the bottom of the stomach. In 2 out of 8 cases, there were signs of malignancy of the tumor with the transition to a highly differentiated adenocarcinoma. According to the results of the IHC study, the absence of a p53 mutation was noted in these cases.

CONCLUSION

PGA should be considered as neoplasms with a high risk of transformation into invasive adenocarcinoma. Increasing the recognition of PGA among pathologists and further understanding of the molecular mechanisms involved in their neoplastic transformation will improve the diagnosis and treatment of this pathology.

Keywords:

pyloric glands adenomas
clinical and morphological characteristics
malignancy

Authors:

Tertychnyy A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pachuashvili N.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Protsenko D.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Avraamova S.T.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Nagornaya D.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pavlov P.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kiryukhin A.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Fedorenko A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

22.10.2023

Accepted:

27.12.2023

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References:

  1. Pezhouh MK, Park JY. Gastric pyloric gland adenoma. Arch Pathol Lab Med. 2015;139(6):823-826.  https://doi.org/10.5858/arpa.2013-0613-RS
  2. Vieth M, Kushima R, Borchard F, Stolte M. Pyloric gland adenoma: a clinico-pathological analysis of 90 cases. Virchows Arch. 2003;442(4):317-321.  https://doi.org/10.1007/s00428-002-0750-6
  3. Chen ZM, Scudiere JR, Abraham SC, Montgomery E. Pyloric gland adenoma: an entity distinct from gastric foveolar type adenoma. Am J Surg Pathol. 2009;33(2):186-193.  https://doi.org/10.1097/PAS.0b013e31817d7ff4
  4. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA; WHO Classification of Tumours Editorial Board. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2): 182-188.  https://doi.org/10.1111/his.13975
  5. Wani Y, Notohara K, Fujisawa M. Aberrant expression of an «intestinal marker» Cdx2 in pyloric gland adenoma of the gallbladder. Virchows Arch. 2008;453(5):521-527.  https://doi.org/10.1007/s00428-008-0680-z
  6. Park JY, Cornish TC, Lam-Himlin D, Shi C, Montgomery E. Gastric lesions in patients with autoimmune metaplastic atrophic gastritis (AMAG) in a tertiary care setting. Am J Surg Pathol. 2010;34(11):1591-1598. https://doi.org/10.1097/PAS.0b013e3181f623af
  7. Miller GC, Kumarasinghe MP, Borowsky J, Choi WT, Setia N, Clauditz T, Gidwani R, Sufiyan W, Lauwers GY, Brown IS. Clinicopathological features of pyloric gland adenomas of the duodenum: a multicentre study of 57 cases. Histopathology. 2020;76(3):404-410.  https://doi.org/10.1111/his.13996
  8. Saei Hamedani F, Garcia-Buitrago M. Pyloric gland adenoma of gallbladder: a review of diagnosis and management. Adv Med. 2018;2018:7539694. https://doi.org/10.1155/2018/7539694
  9. He C, Fukumura Y, Toriyama A, Ogura K, Sasahara N, Mitani K, Yao T. Pyloric gland adenoma (PGA) of the gallbladder: a unique and distinct tumor from PGAs of the stomach, duodenum, and pancreas. Am J Surg Pathol. 2018;42(9):1237-1245. https://doi.org/10.1097/PAS.0000000000001117
  10. Li HL, Wang Y, Ren YB, Yang, XS, Wang L, Zhang L, Lin XC. Pyloric gland adenoma with low-grade intraepithelial neoplasia: a case report and literature review. Medicine (Baltimore). 2021; 100(25):e26378. https://doi.org/10.1097/MD.0000000000026378
  11. Choi WT, Brown I, Ushiku T, Yozu M, Setia N, Srivastava A, Johncilla M, Pai RK, Gill RM, Fukayama M, et al. Gastric pyloric gland adenoma: a multicentre clinicopathological study of 67 cases. Histopathology. 2018;72(6):1007-1014. https://doi.org/10.1111/his.13460
  12. Pei Q, Shi Y, Jing H. Early adenocarcinoma colliding with a pyloric gland adenoma in the gastric cardia. Gastrointest Endosc. 2019; 90(3):522-523.e1.  https://doi.org/10.1016/j.gie.2019.04.225
  13. Yamamoto M, Nishida T, Nakamatsu D, Adachi S, Inada M. Endoscopic findings of inverted pyloric gland adenoma resected by endoscopic submucosal dissection. J Gastrointestin Liver Dis. 2018;27(4):361.  https://doi.org/10.15403/jgld.2014.1121.274.end
  14. Min CC, Wu J, Hou F, Mao T, Li XY, Ding XL, Liu H. Gastric pyloric gland adenoma resembling a submucosal tumor: a case report. World J Clin Cases. 2020;8(11):2380-2386. https://doi.org/10.12998/wjcc.v8.i11.2380
  15. Kushima R, Müller W, Stolte M, Borchard F. Differential p53 protein expression in stomach adenomas of gastric and intestinal phenotypes: possible sequences of p53 alteration in stomach carcinogenesis. Virchows Arch. 1996;428(4-5):223-227.  https://doi.org/10.1007/BF00196694
  16. Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, Kanai Y. Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. J Pathol. 2013;229(4): 579-587.  https://doi.org/10.1002/path.4153
  17. Endoh Y, Sakata K, Tamura G, Ohmura K, Ajioka Y, Watanabe H, Motoyama T. Cellular phenotypes of differentiated-type adenocarcinomas and precancerous lesions of the stomach are dependent on the genetic pathways. J Pathol. 2000;191(3):257-263.  https://doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH631>3.0.CO;2-2
  18. Ohmura K, Tamura G, Endoh Y, Sakata K, Takahashi T, Motoyama T. Microsatellite alterations in differentiated-type adenocarcinomas and precancerous lesions of the stomach with special reference to cellular phenotype. Hum Pathol. 2000;31(9):1031-1035. https://doi.org/10.1053/hupa.2000.16669
  19. Abraham SC, Park SJ, Lee JH, Mugartegui L, Wu TT. Genetic alterations in gastric adenomas of intestinal and foveolar phenotypes. Mod Pathol. 2003;16(8):786-795.  https://doi.org/10.1097/01.MP.0000080349.37658.5E
  20. Matsubara A, Sekine S, Kushima R, Ogawa R, Taniguchi H, Tsuda H, Kanai Y. Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum. J Pathol. 2013; 229(4):579-587.  https://doi.org/10.1002/path.4153
  21. Hackeng WM, Montgomery EA, Giardiello FM, Singhi AD, Debeljak M, Eshleman JR, Vieth M, Offerhaus GJ, Wood LD, Brosens LA. Morphology and genetics of pyloric gland adenomas in familial adenomatous polyposis. Histopathology. 2017;70(4):549-557.  https://doi.org/10.1111/his.13105
  22. Zacharin M, Bajpai A, Chow CW, Catto-Smith A, Stratakis C, Wong MW, Scott R. Gastrointestinal polyps in McCune Albright syndrome. J Med Genet. 2011;48(7):458-461.  https://doi.org/10.1136/jmg.2010.086330
  23. Korsse SE, Peppelenbosch MP, Smits R, van Veelen W. GNAS is not involved in gastrointestinal tumour formation in Peutz-Jeghers syndrome. Fam Cancer. 2013;12(3):581-582.  https://doi.org/10.1007/s10689-013-9602-6
  24. Buffart TE, Carvalho B, Mons T, Reis RM, Moutinho C, Silva P, van Grieken NCT, Vieth M, Stolte M, de Velde CJH, et al. DNA copy number profiles of gastric cancer precursor lesions. BMC Genomics. 2007;8:345.  https://doi.org/10.1186/1471-2164-8-345
  25. Kushima R, Vieth M, Borchard F, Stolte M, Mukaisho K, Hattori T. Gastric-type well-differentiated adenocarcinoma and pyloric gland adenoma of the stomach. Gastric Cancer. 2006;9(3):177-184.  https://doi.org/10.1007/s10120-006-0381-8
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