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Tertychnyy A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pachuashvili N.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Protsenko D.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Avraamova S.T.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Nagornaya D.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pavlov P.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kiryukhin A.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Fedorenko A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pyloric gland adenoma — a rare tumor of the upper gastrointestinal tract with a high risk of malignancy

Authors:

Tertychnyy A.S., Pachuashvili N.V., Protsenko D.D., Avraamova S.T., Nagornaya D.P., Pavlov P.V., Kiryukhin A.P., Fedorenko A.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(2): 30‑36

DOI: 10.17116/patol20248602130

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Table of contents

To cite this article:

Tertychnyy AS, Pachuashvili NV, Protsenko DD, et al. . Pyloric gland adenoma — a rare tumor of the upper gastrointestinal tract with a high risk of malignancy. Russian Journal of Archive of Pathology. 2024;86(2):30‑36. (In Russ.)
https://doi.org/10.17116/patol20248602130

Подписка 2025 (Russian Journal of Archive of Pathology)
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BACKGROUND

Pyloric gland adenomas (PGA) are rare neoplasms of the gastrointestinal tract. According to the literature, these lesions may be underdiagnosed, and their true frequency of occurrence is underestimated.

OBJECTIVE

Clinical and morphological analysis of eight PGA cases of the upper gastrointestinal tract.

MATERIAL AND METHODS

The study included 8 cases of detection of PGA. In 7 out of 8 cases, the tumor was diagnosed by examining endoscopic biopsies, in 1 case, PGA was an accidental finding in the surgical material after proximal gastric resection.

RESULTS

6 out of 8 patients were female, the median age was 65 years (minimum 36 years and maximum 78 years). In 6 cases, PDA was localized in the stomach, in 1 — in the esophagus and in 1 — in the duodenum The size of the tumors ranged from 0.6 cm to 7.5 cm. 4 out of 6 stomach tumors appeared on the background of confirmed autoimmune gastritis, 1 — on the background of lymphocytic gastritis. 4 tumors were found in the body of the stomach, 1 — in the cardia, 1 — in the bottom of the stomach. In 2 out of 8 cases, there were signs of malignancy of the tumor with the transition to a highly differentiated adenocarcinoma. According to the results of the IHC study, the absence of a p53 mutation was noted in these cases.

CONCLUSION

PGA should be considered as neoplasms with a high risk of transformation into invasive adenocarcinoma. Increasing the recognition of PGA among pathologists and further understanding of the molecular mechanisms involved in their neoplastic transformation will improve the diagnosis and treatment of this pathology.

Keywords:

pyloric glands adenomas
clinical and morphological characteristics
malignancy

Authors:

Tertychnyy A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pachuashvili N.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Protsenko D.D.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Avraamova S.T.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Nagornaya D.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Pavlov P.V.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Kiryukhin A.P.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Fedorenko A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

22.10.2023

Accepted:

27.12.2023

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