The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Timakova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Osmanov Yu.I.

Scientific and Clinical Center of Russian Railways;
I.M. Sechenov First Moscow State Medical University

IgG4-related ophthalmopathy

Authors:

Radenska-Lopovok S.G., Tertychnyi A.S., Timakova A.A., Osmanov Yu.I.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(4): 45‑50

DOI: 10.17116/patol20228404145

Read: 2457 times

Download PDF (RU)
Contact the author
Table of contents

IGG4-RELATED OPHTHALMOPATHY
IGG4-RELATED OPHTHALMOPATHY

To cite this article:

Radenska-Lopovok SG, Tertychnyi AS, Timakova AA, Osmanov YuI. IgG4-related ophthalmopathy. Russian Journal of Archive of Pathology. 2022;84(4):45‑50. (In Russ.)
https://doi.org/10.17116/patol20228404145

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Autoimmune diseases of central nervous system and respiratory viral infe­ctions in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):39-46
Masks of autoimmune diseases: a multidisciplinary approach to the problem. Journal of Respiratory Medi­cine. 2025;(1):58-64
Application of T-cells with chimeric anti­gen rece­ptor in the treatment of refractory autoimmune diseases. Russian Journal of Preventive Medi­cine. 2025;(7):106-110
Abstract:

IgG4-related disease is a chronic inflammatory fibrosing disease of unknown etiology, characterized by the presence of volumetric lesions that can clinically simulate malignant tumors, a pronounced IgG4-positive lymphoplasmacytic infiltrate, and an increase in the level of IgG4 in the blood serum. A special form of the disease is IgG4-related ophthalmopathy, which requires differential diagnosis with inflammatory pseudotumor, lymphoma and granulomatous polyangiitis. 7 clinical cases of IgG4-related ophthalmopathy are presented. It has been shown that follicle-like structures with the structure of a lymph node are formed in the tissues of the orbit. Along with a large number of cells in the inflammatory infiltrate expressing CD138, IgG and IgG4, there are CD8+ and CD68+ cells. IgG4-related ophthalmopathy is a rare manifestation of IgG4-related disease. Its morphogenesis involves not only IgG, IgG4 and CD138 positive plasma cells, which are diagnostic. CD8 and CD68- positive cells are involved too. They persisted in large quantity in the lymphohistiocytic infiltrate. The study of the lymphocyte population can help in revealing the pathogenesis and morphogenesis of this rare disease.

Keywords:

IgG4-related disease
IgG4-related ophtalmic disease
autoimmune diseases

Authors:

Radenska-Lopovok S.G.

I.M. Sechenov First Moscow State Medical University

Tertychnyi A.S.

I.M. Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Health of Russia

Timakova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Osmanov Yu.I.

Scientific and Clinical Center of Russian Railways;
I.M. Sechenov First Moscow State Medical University

Received:

18.03.2022

Accepted:

27.04.2022

Close metadata

References:

  1. Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, Fukushima M, Nikaido T, Nakayama K, Usuda N, Kiyosawa K. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344(10):732-738.  https://doi.org/10.1056/NEJM200103083441005
  2. Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, Okamoto A, Egawa N, Nakajima H. A new clinicopathological entity of IgG4-related autoimmune disease. J Gastroenterol. 2003;38(10):982-984.  https://doi.org/10.1007/s00535-003-1175-y
  3. Umehara H, Okazaki K, Kawa S, Takahashi H, Goto H, Matsui S, Ishizaka N, Akamizu T, Sato Y, Kawano M. Research Program for Intractable Disease by the Ministry of Health, Labor and Welfare (MHLW) Japan. The 2020 revised comprehensive diagnostic (RCD) criteria for IgG4-RD. Mod Rheumatol. 2021; 31(3):529-533.  https://doi.org/10.1080/14397595.2020.1859710
  4. Deshpande V, Zen Y, Chan JK, Yi EE, Sato Y, Yoshino T, Klöppel G, Heathcote JG, Khosroshahi A, Ferry JA, Aalberse RC, Bloch DB, Brugge WR, Bateman AC, Carruthers MN, et al. Consensus statement on the pathology of IgG4-related disease. Mod Pathol. 2012;25(9):1181-1192. https://doi.org/10.1038/modpathol.2012.72
  5. Wallace ZS, Naden RP, Chari S, Choi H, Della-Torre E, Dicaire J-F, et al. IgG4-Related Disease Classification Criteria Working Group. The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4-Related Disease. Arthritis Rheumatol. 2020;72(1):7-19.  https://doi.org/10.1002/art.41120
  6. Kuroda N, Nao T, Fukuhara H, Karashima T, Inoue K, Taniguchi Y, Takeuchi M, Zen Y, Sato Y, Notohara K, Yoshino T. IgG4-related renal disease: clinical and pathological characteristics. Int J Clin Exp Pathol. 2014;15;7(9):6379-6385. PMCID: PMC4203266.
  7. Lishchuk SV, Kazantseva IA, Dubova EA, Pavlov KA, Katunina OR, Borbat AM, Udalov IuD. Morphological features of IgG4-related lesions at various sites. Arkhiv patologii. 2019;81(5): 22-29. (In Russ.). https://doi.org/10.17116/patol20198105122
  8. Lishchuk SV, Dubova EA, Pavlov KA, Borbat AM, Udalov YuD. Clinical and morphological characteristics IgG4-associated retroperitoneal fibrosis. Almanac of Clinical Medicine. 2020;48(2): 110-116.  https://doi.org/10.18786/2072-0505-2020-48-010
  9. Perugino CA, Stone JH. IgG4-related disease: an update on pathophysiology and implications for clinical care. Nat Rev Rheumatol. 2020;16:702-714.  https://doi.org/10.1038/s41584-020-0500-7
  10. De Sainte Marie B, Urban ML, Vély F, Seguier J, Grados A, Daniel L, Ebbo M, Schleinitz N. Pathophysiology of IgG4-related disease: A T follicular helper cells disease? La Presse Médicale. 2020;49(1):104013. https://doi.org/10.1016/j.lpm.2020.104013
  11. Suimon Y, Kase S, Ishijima K, Kanno-Okada H, Ishida S. A clinicopathological study on IgG4-related ophthalmic disease. Int J Ophthalmol. 2018;11(9):1539-1544. https://doi.org/10.18240/ijo.2018.09.18
  12. Yu WK, Tsai CC, Kao SC, Liu CJ. Immunoglobulin G4-related ophthalmic disease. Taiwan J Ophthalmol. 2018;8(1):9-14.  https://doi.org/10.4103/tjo.tjo_12_17
  13. Goto H, Ueda SI, Nemoto R, Ohshima KI, Sogabe Y, Kitagawa K, Ogawa Y, Oyama T, Furuta M, Azumi A, Takahira M. Clinical features and symptoms of IgG4-related ophthalmic disease: A multicenter study. Jpn J Ophthalmol. 2021;65(5):651-656.  https://doi.org/10.1007/s10384-021-00847-3
  14. Min HK, Lee YS, Yang SW, Lee J, Kwok SK, Ju JH, Kim WU, Park SH. Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor. Korean J Intern Med. 2019;34(1):220-226.  https://doi.org/10.3904/kjim.2016.304.
  15. Goto H, Takahira M, Azumi A; Japanese Study Group for IgG4-Related Ophthalmic Disease. Diagnostic criteria for IgG4-related ophthalmic disease. Jpn J Ophthalmol. 2015;59(1):1-7.  https://doi.org/10.1007/s10384-014-0352-2
  16. McNab AA, McKelvie P. IgG4-related ophthalmic disease. Part I: background and pathology. Ophthalmic Plast Reconstr Surg. 2015; 31(2):83-88.  https://doi.org/10.1097/IOP.0000000000000363
  17. Yu WK, Kao SC, Yang CF, Lee FL, Tsai CC. Ocular adnexal IgG4-related disease: clinical features, outcome, and factors associated with response to systemic steroids. Jpn J Ophthalmol. 2015;59(1):8-13.  https://doi.org/10.1007/s10384-014-0353-1
  18. Son KY, Woo KI, Kim YD. Clinical Outcomes of IgG4-Related Ophthalmic Disease and Idiopathic Sclerosing Orbital Inflammation. Ophthalmic Plast Reconstr Surg. 2022;38(1):34-39.  https://doi.org/10.1097/IOP.0000000000001975
  19. Li HQ, Lin JY, Zhao H. [Clinical and pathological study on IgG4-related ophthalmic disease involving the lacrimal gland]. Zhonghua Yan Ke Za Zhi. 2019;55(11):834-841. (In Chinese). https://doi.org/10.3760/cma.j.issn.0412-4081.2019.11.009
  20. Yu WK, Tsai CC, Kao SC, Liu CJ. Immunoglobulin G4-related ophthalmic disease. Taiwan J Ophthalmol. 2018;8(1):9-14.  https://doi.org/10.4103/tjo.tjo_12_17
  21. Maehara T, Mattoo H, Ohta M, Mahajan VS, Moriyama M, Yamauchi M, Drijvers J, Nakamura S, Stone JH, Pillai ShS. Lesional CD4+ IFN-γ+ cytotoxic T lymphocytes in IgG4-related dacryoadenitis and sialoadenitis. Ann Rheum Dis. 2017;76(2):377-385.  https://doi.org/10.1136/annrheumdis-2016-209139
  22. Weiskopf D, Bangs DJ, Sidney J, Kolla RV, De Silva AD, de Silva AM, Crotty Sh, Peters B, Sette A. Dengue virus infection elicits highly polarized CX3CR1+ cytotoxic CD4+ T cells associated with protective immunity. Proc Natl Acad Sci USA. 2015;112:4256-4263. Epub 2015 July 20  https://doi.org/10.1073/pnas.1505956112
  23. Tian Y, Babor M, Lane J, Schulten V, Patil VS, Seumois G, Rosales SL, Fu Z, Picarda G, Burel J, Zapardiel-Gonzalo J, Tennekoon RN, et al. Unique phenotypes and clonal expansions of human CD4 effector memory T cells reexpressing CD45RA. Nat Commun. 2017;8:1473. https://doi.org/10.1038/s41467-017-01728-5
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.