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Timoshenko O.S.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Gureeva T.A.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Kugaevskaya E.V.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Solovуeva N.I.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

The expression of EMMPRIN and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma

Authors:

Timoshenko O.S., Gureeva T.A., Kugaevskaya E.V., Zavalishina L.É., Andreeva Yu.Yu., Solovуeva N.I.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2019;81(6): 34‑40

DOI: 10.17116/patol20198106134

Views: 886

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To cite this article:

Timoshenko OS, Gureeva TA, Kugaevskaya EV, Zavalishina LÉ, Andreeva YuYu, Solovуeva NI. The expression of EMMPRIN and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma. Russian Journal of Archive of Pathology. 2019;81(6):34‑40. (In Russ.)
https://doi.org/10.17116/patol20198106134

Подписка 2025 (Russian Journal of Archive of Pathology)
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Objective — to investigate the features of expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and the matrix metalloproteinase MMP-1 in the cervix uteri and corpus uteri in cervical squamous cell carcinoma (CSCC). Material and methods. The investigation was conducted using the surgical material obtained after hysterectomy in patients diagnosed as having CSCC. RT-PCR, immunohistochemistry (IHC), and enzymatic assays were used. Results. The high expression of EMMPRIN and MMP-1 in CSCC was found not only in cervical carcinoma, but also in the stroma and epithelium of the cervix uteri and corpus uteri outside the tumor, whereas the level of MMP-1 expression in the morphologically intact tissue was significantly lower than in the tumor, while that of EMMPRIN gene expression did not differ substantially. Conclusion. The expression of EMMPRIN and MMP-1 in CSCC occurs in both the tumor and the morphologically intact tissue, which may suggest that the invasive potential of tumor may increase and therefore have prognostic value.

Keywords:

EMMPRIN
matrix metalloproteinase MMP-1
cervical squamous cell carcinoma

Authors:

Timoshenko O.S.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Gureeva T.A.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Kugaevskaya E.V.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

Zavalishina L.É.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Andreeva Yu.Yu.

Russian Medical Academy of Continuing Professional Education, Ministry of Health of Russia

Solovуeva N.I.

V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences

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