The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Liskova Yu.V.

Orenburg State Medical University, Ministry of Health of Russia, Orenburg

Stadnikov A.A.

Orenburg State Medical Academy, 6 Sovetskaya St., Orenburg, Russian Federation, 460000

Salikova S.P.

S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg

Role of telocytes in the heart in health and diseases

Authors:

Liskova Yu.V., Stadnikov A.A., Salikova S.P.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2017;79(2): 58‑63

DOI: 10.17116/patol201779258-63

Views: 2141

Downloaded: 117

Download PDF (RU)
Contact the author
Table of contents

ROLE OF TELOCYTES IN THE HEART IN HEALTH AND DISEASES
ROLE OF TELOCYTES IN THE HEART IN HEALTH AND DISEASES

To cite this article:

Liskova YuV, Stadnikov AA, Salikova SP. Role of telocytes in the heart in health and diseases. Russian Journal of Archive of Pathology. 2017;79(2):58‑63. (In Russ.)
https://doi.org/10.17116/patol201779258-63

Подписка 2025-2 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Close metadata
Recommended articles:
Histological and ultrastructural analysis of biopsy specimens of donor heart under conditions of exte­nded period of pharmaco-cold ischaemia. Russian Journal of Archive of Pathology. 2024;(5):33-41
Ultrastructural changes of skeletal muscle tissue of patients with dysferlinopathy. Russian Journal of Archive of Pathology. 2025;(1):28-36
Asse­ssment study on effect of omega-3 polyu­nsaturated fatty acids intake on cardiovascular system performance in men born in the Far East. Russian Journal of Preventive Medi­cine. 2025;(2):46-52
Analysis of differential gene expression in myocardial tissue from patients with hype­rtrophic cardiomyopathy. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(1):17-23

This review summarizes the data available in the literature on the development, structure, and function of telocytes (TCs) and their role in the heart in health and diseases. At the present time, TCs have been found in many organs of mammals and humans. TC is a small oval cell that contains a nucleus surrounded by small amounts of cytoplasm, with extremely long and thin processes named telopodias. TCs have unique ultrastructural and immunohistochemical features; double positive labeling for CD34/PDGFR-β and CD34/vimentin is suitable for their identification. The role of TCs in the heart at different study stages is the subject of debate. There are currently available data on a decline in the number of cardiac TCs in patients with various heart diseases. Relying on a number of investigations showing that TCs are present in the subepicardial stem cell niches, the authors consider a hypothesis for the key role of cardiac TCs in the regeneration and reparation of the heart.

Keywords:

telocytes
cardiomyocytes
myocardium
remodeling

Authors:

Liskova Yu.V.

Orenburg State Medical University, Ministry of Health of Russia, Orenburg

Stadnikov A.A.

Orenburg State Medical Academy, 6 Sovetskaya St., Orenburg, Russian Federation, 460000

Salikova S.P.

S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg

List of references:

  1. Popescu LM, Faussone-Pellegrini MS. Telocytes — A case of serendipity: the winding way from Interstitial Cells of Cajal (ICC), via Interstitial Cajal-Like Cells (ICLC) to telocytes. J Cell Mol Med. 2010;14(4):729-740. doi:10.1111/j.1582-4934.2010.01059.x
  2. Gherghiceanu M, Popescu LМ. Cardiomyocyte precursors and telocytes in epicardial stem cell niche: еlectron microscope images. J Cell Mol Med. 2010;14(4):871-877. doi:10.1111/j.1582-4934.2010.01060.x
  3. Popescu LM, Gherghiceanu M, Manole CG, Faussone-Pellegrini MS. Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med. 2009;13(5):866-886. doi:10.1111/j.1582-4934.2009.00758.x
  4. Doljanski F. The sculpturing role of fibroblast-like cells in morphogenesis. Perspect Biol Med. 2004;47(3):339-356. doi:10.1353/pbm.2004.0048
  5. Hay ED. Cell and extracellular matrix: their organization and mutual dependence. Modern Cell Biol. 1983;2:509-548.
  6. McClay DR. The role of thin filopodia in motility and morphogenesis. Exp Cell Res. 1999;253(2):296-301. doi:10.1006/excr.1999.4723
  7. Mikawa Т, Hurtado R. Development of the cardiac conduction system. Semin Cell Dev Biol. 2007;18:90-100. doi:10.1016/j.semcdb.2006.12.008
  8. Sedmera D, Pexieder T, Vuillemin M, et al. Developmental patterning of the myocardium. Anat Rec. 2000;258(4):319-37. doi:10.1002/(SICI)1097-0185(20000401)258:4319::AID-AR13.0.CO;2-O
  9. Gittenberger-de Groot AC, Winter EM, Poelmann RE. Epicardium-derived cells (EPDCs) in development, cardiac disease and repair of ischemia. J Cell Mol Med. 2010;14(5):1056-1060. doi:10.1111/j.1582-4934.2010.01077.x
  10. Lie-Venema H, van den Akker NM, Bax NA, et al. Origin, fate, and function of epicardium-derived cells (EPDCs) in normal and abnormal cardiac development. Scientific World Journal. 2007;12(7):1777-1798. doi:10.1100/tsw.2007.294
  11. Sucov HM, Gu Y, Thomas S, et al. Epicardial control of myocardial proliferation and morphogenesis. Pediatr Cardiol. 2009;30(5):617-625. doi:10.1007/s00246-009-9391-8
  12. Torella D, Ellison GM, Mèndez-Ferrer S, et al. Resident human cardiac stem cells: role in cardiac cellular homeostasis and potential for myocardial regeneration. Nat Clin Pract Cardiovasc Med. 2006;3:8-13. doi:10.1038/ncpcardio0409
  13. Wessels A, Pèrez-Pomares JM. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat Rec A Discov Mol Cell Evol Biol. 2004; 276(1):43-57. doi:10.1002/ar.a.10129
  14. Winter EM, Gittenberger-de Groot AC. Epicardium-derived cells in cardiogenesis and cardiac regeneration. Cell Mol Life Sci. 2007;64(6):692-703. doi:10.1007/s00018-007-6522-3
  15. Kostin S. Myocardial telocytes: a new distinct cellular entity. J Cell Mol Med. 2010;14(7):1917-21. doi:10.1111/j.1582-4934.2010.01111.x
  16. Kostin S, Popescu LM. A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs). J Cell Mol Med. 2009;13(2):295-308. doi:10.1111/j.1582-4934.2008.00668.x
  17. Hinescu ME, Gherghiceanu M, Mandache E, et al. Interstitial Cajal-like cells (ICLC) in atrial myocardium: ultrastructural and immunohistochemical characterization. J Cell Mo. Med. 2006;10(1):243-257. doi:10.1111/j.1582-4934.2006.tb00306.x
  18. Rafii S, Lyden D. Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med. 2003;9(6):702-712. doi:10.1038/nm0603-702
  19. Bani D, Formigli L, Gherghiceanu M, et al. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med. 2010;14:2531-2538. doi:10.1111/j.1582-4934.2010.01119.x
  20. Gherghiceanu M, Hinescu ME, Andrei F, et al. Interstitial Cajal-like cells (ICLC) in myocardial sleeves of human pulmonary veins. J Cell Mol Med. 2008;12:1777-1781. doi:10.1111/j.1582-4934.2008.00444.x
  21. Gherghiceanu M, Hinescu ME, Popescu LM. Myocardial interstitial Cajal-like cells (ICLC) in caveolin-1 KO mice. J Cell Mol Med. 2009;13(1):202-206. doi:10.1111/j.1582-4934.2008.00615.x
  22. Gherghiceanu M, Manole CG, Popescu LM. Telocytes in endocardium: electron microscope evidence. J Cell Mol Med. 2010;14(9):2330-2334. doi:10.1111/j.1582-4934.2010.01133.x
  23. Gherghiceanu M, Popescu LM. Heterocellular communication in the heart: electron tomography of telocyte-myocyte junctions. J Cell Mol Med. 2011;15:1005-1011. doi:10.1111/j.1582-4934.2011.01299.x
  24. Hinescu ME, Ardeleanu C, Gherghiceanu M, et al. Interstitial Cajal-like cells in human gallbladder. J Mol Histol. 2007;38:275-284. doi:10.1007/s10735-007-9099-0
  25. Hinescu ME, Popescu LM, Gherghiceanu M, et al. Interstitial Cajal-like cells in rat mesentery: an ultrastructural and immunohistochemical approach. J Cell Mol Med. 2008;12:260-270. doi:10.1111/j.1582-4934.2008.00226.x
  26. Popescu LM, Ciontea SM, Cretoiu D. Interstitial Cajal-like cells in human uterus and fallopian tube. Ann NY Acad Sci. 2007;1101:139-165. doi:10.1196/annals.1389.022
  27. Popescu L, Hinescu M, Radu E. CD117/c-kit positive interstitial (Cajal-like) cells in human pancreas. J Cell Mol Med. 2005;9(3):738-739. doi:10.1111/j.1582-4934.2005.tb00505.x
  28. Garcia-Lopez P, Garcia-Marin V, Martinez-Murillo R, et al. Updating old ideas and recent advances regarding the Interstitial Cells of Cajal. Brain Res Rev. 2009;61:154-169. doi:10.1016/j.brainresrev.2009.06.001
  29. Cretoiu SM, Popescu LM. Telocytes revisited. Biomol Concepts. 2014;5(5):353-369. doi:10.1515/bmc-2014-0029
  30. Ciontea SM, Radu E, Regalia T, et al. C-kit immunopositive interstitial cells (Cajal-type) in human myometrium. J Cell Mol Med. 2005;9(2):407-420. doi:10.1111/j.1582-4934.2005.tb00366.x
  31. Zhou J, Wang Y, Zhu P, et al. Distribution and characteristics of telocytes as nurse cells in the architectural organization of engineered heart tissues. Sci China Life Sci. 2014;57(2):241-247. doi:10.1007/s11427-013-4602-1
  32. Koh BH, Roy R, Hollywood MA, et al. Platelet-derived growth factor receptor-α cells in mouse urinary bladder: a new class of interstitial cells. J Cell Mol Med. 2012;16(4):691-700. doi:10.1111/j.1582-4934.2011.01506.x
  33. Pieri L, Vannucchi MG, Faussone-Pellegrini MS. Histochemical and ultrastructural characteristics of an interstitial cell type different from ICC and resident in the muscle coat of human gut. J Cell Mol Med. 2008;12(5b):1944-1955. doi:10.1111/j.1582-4934.2008.00461.x
  34. Vannucchi MG, Traini C, Guasti D, et al. Telocytes subtypes in human urinary bladder. J Cell Mol Med. 2014;18:2000-2008. doi:10.1111/jcmm.12375
  35. Vannucchi MG, Traini C, Manetti M, et al. Telocytes express PDGFRα in the human gastrointestinal tract. J Cell Mol Med. 2013;17(9):1099-1108. doi:10.1111/jcmm.12134
  36. Wang F, Song Y, Bei Y, et al. Telocytes in liver regeneration: possible roles. J Cell Mol Med. 2014;18(9):1720-1726. doi:10.1111/jcmm.12355
  37. Bei Y, Wang F, Yang C, Xiao J. Telocytes in regenerative medicine. J Cell Mol Med. 2015;19(7):1441-1454. doi:10.1111/jcmm.12594
  38. Milia AF, Ruffo M, Manetti M, et al. Telocytes in Crohn’s disease. J Cell Mol Med. 2013;17:1525-1536. doi:10.1111/jcmm.12177
  39. Gherghiceanu M, Popescu LM. Cardiac telocytes - their junctions and functional implications. Cell Tissue Res. 2012;348(2):265-279. doi:10.1007/s00441-012-1333-8
  40. Fertig ET, Gherghiceanu M, Popescu LM. Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography. J Cell Mol Med. 2014;18:1938-1943. doi:10.1111/jcmm.12436
  41. Zhou J, Zhang Y, Wen X, et al. Telocytes accompanying cardiomyocyte in primary culture: two- and three-dimensional culture environment. J Cell Mol Med. 2010;14(11):2641-2645. doi:10.1111/j.1582-4934.2010.01186.x
  42. Popescu LM, Curici А, Wang Е, et al. Telocytes and putative stem cells in ageing human heart. J Cell Mol Med. 2015;19(1):31-45. doi:10.1111/jcmm.12509
  43. Edelstein L, Smythies J. The role of telocytes in morphogenetic bioelectrical signaling: once more unto the breach. Front Mol Neurosci. 2014;7:41. doi:10.3389/fnmol.2014.00041
  44. Faussone-Pellegrini MS, Bani D. Relationships between telocytes and cardiomyocytes during pre- and postnatal life. J Cell Mol Med. 2010;14:1061-1063. doi:10.1111/j.1582-4934.2010.01074.x
  45. Liu JJ, Shen XT, Zheng X, et al. Distribution of telocytes in the rat heart. J Clin Rehabil Tiss Eng Res. 2011;15:3546-3548.
  46. Popescu LM, Manole CG, Gherghiceanu M, et al. Telocytes in human epicardium. J Cell Mol Med. 2010;14(8):2085-2093. doi:10.1111/j.1582-4934.2010.01129.x
  47. Popescu LM, Gherghiceanu M, Hinescu ME, et al. Insights into the interstitium of ventricular myocardium: interstitial Cajal like cells (ICLC). J Cell Mol Med. 2006;10(2):429-58. doi:10.1111/j.1582-4934.2006.tb00410.x
  48. Gherghiceanu M, Popescu LМ. Human epicardium: ultrastructural ancestry of mesothelium and mesenchymal cells. J Cell Mol Med. 2009;13:2949-2951. doi:10.1111/j.1582-4934.2009.00869.x
  49. Mandache E, Popescu LM, Gherghiceanu M. Myocardial interstitial Cajal-like cells (ICLC) and their nanostructural relationships with intercalated discs: shed vesicles as intermediates. J Cell Mol Med. 2007;11(5):1175-1184. doi:10.1111/j.1582-4934.2007.00117.x
  50. Manole CG, Cismaşiu V, Gherghiceanu M, Popescu LM. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011;15(11):2284-2296. doi:10.1111/j.1582-4934.2011.01449.x
  51. Suciu L, Popescu LM, Regalia T, et al. Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med. 2009;14:771-777. doi:10.1111/j.1582-4934.2009.00756.x
  52. Limana F, Bertolami C, Mangoni A, et al. Myocardial infarction induces embryonic reprogramming of epicardial c-kit(+) cells: role of the pericardial fluid. J Mol Cell Cardiol. 2010;48(4):609-618. doi:10.1016/j.yjmcc
  53. Urbanek K, Cesselli D, Rota M, et al. Stem cell niches in the adult mouse heart. Proc Natl Acad Sci USA. 2006;103(24):9226-9231. doi:10.1073/pnas.0600635103
  54. Cohn JN, Ferrari R, Sharpe N. Cardiac remodeling-concepts and clinical implications: A consensus paper froman international forum on cardiac remodeling. J Am Coll Cardiol. 2000;35(3):569-582. doi:10.1016/S0735-1097(99)00630-0
  55. Polyakova V, Hein S, Kostin S, et al. Matrix metalloproteinases and their tissue inhibitors in pressure-overloaded human myocardium during heart failure progression. J Am Coll Cardiol. 2004;44(8):1609-1618. doi:10.1016/j.jacc.2004.07.023
  56. Polyakova V, Loeffler I, Hein S, et al. Fibrosis in end stage human heart failure: Disease-specific changes in collagen metabolism and MMP/TIMP profiles. Int J Cardiol. 2011;151(1):18-33. doi:10.1016/j.ijcard.2010.04.053
  57. Polyakova V, Miyagawa S, Szalay Z, et al. Atrial extracellular matrix remodelling in patients with atrial fibrillation. J Cell Mol Med. 2008;12(1):189-208. doi:10.1111/j.1582-4934.2008.00219.x
  58. Zhao B, Chen S, Liu J, et al. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J Cell Mol Med. 2013;17(1):123-133. doi:10.1111/j.1582-4934.2012.01655.x
  59. Richter М, Kostin S. The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition. J Cell Mol Med. 2015;19(11):2597-2606. doi:10.1111/jcmm.12664
  60. Lionetti V, Bianchi G, Recchia FA, et al. Control of autocrine and paracrine myocardial signals: an emerging therapeutic strategy in heart failure. Heart Fail Rev. 2010;15(6):531-542. doi:10.1007/s10741-010-9165-7
  61. Zheng YH, Bai CX, Wang XD. Telocyte morphologies and potential roles in diseases. J Cell Physiol. 2012;227(6):2311-2317. doi:10.1002/jcp.23022

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.