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Liskova Yu.V.

Orenburg State Medical University, Ministry of Health of Russia, Orenburg

Stadnikov A.A.

Orenburg State Medical Academy, 6 Sovetskaya St., Orenburg, Russian Federation, 460000

Salikova S.P.

S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg

Role of telocytes in the heart in health and diseases

Authors:

Liskova Yu.V., Stadnikov A.A., Salikova S.P.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2017;79(2): 58‑63

DOI: 10.17116/patol201779258-63

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Table of contents

ROLE OF TELOCYTES IN THE HEART IN HEALTH AND DISEASES
ROLE OF TELOCYTES IN THE HEART IN HEALTH AND DISEASES

To cite this article:

Liskova YuV, Stadnikov AA, Salikova SP. Role of telocytes in the heart in health and diseases. Russian Journal of Archive of Pathology. 2017;79(2):58‑63. (In Russ.)
https://doi.org/10.17116/patol201779258-63

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

This review summarizes the data available in the literature on the development, structure, and function of telocytes (TCs) and their role in the heart in health and diseases. At the present time, TCs have been found in many organs of mammals and humans. TC is a small oval cell that contains a nucleus surrounded by small amounts of cytoplasm, with extremely long and thin processes named telopodias. TCs have unique ultrastructural and immunohistochemical features; double positive labeling for CD34/PDGFR-β and CD34/vimentin is suitable for their identification. The role of TCs in the heart at different study stages is the subject of debate. There are currently available data on a decline in the number of cardiac TCs in patients with various heart diseases. Relying on a number of investigations showing that TCs are present in the subepicardial stem cell niches, the authors consider a hypothesis for the key role of cardiac TCs in the regeneration and reparation of the heart.

Keywords:

telocytes
cardiomyocytes
myocardium
remodeling

Authors:

Liskova Yu.V.

Orenburg State Medical University, Ministry of Health of Russia, Orenburg

Stadnikov A.A.

Orenburg State Medical Academy, 6 Sovetskaya St., Orenburg, Russian Federation, 460000

Salikova S.P.

S.M. Kirov Military Medical Academy, Ministry of Defense of the Russian Federation, Saint Petersburg

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