Markers of angiogenesis in tumor growth

The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Search result: 0

Nefedova N.A.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova"

Kharlova O.A.

Russian Medical Academy of Postgraduate Education, Moscow

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Mal'kov P.G.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Markers of angiogenesis in tumor growth

Authors:

Nefedova N.A., Kharlova O.A., Danilova N.V., Mal'kov P.G., Gaifullin N.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2016;78(2): 55‑63

DOI: 10.17116/patol201678255-62

Read: 16010 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Nefedova NA, Kharlova OA, Danilova NV, Mal'kov PG, Gaifullin NM. Markers of angiogenesis in tumor growth. Russian Journal of Archive of Pathology. 2016;78(2):55‑63. (In Russ.)
https://doi.org/10.17116/patol201678255-62

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

Close metadata

Abstract:

Angiogenesis is a process of new blood vessels formation. The role of angiogenesis in growth, invasion and metastasis of malignant tumours is nowadays universally recognized. Though, investigation of mechanisms of blood vessels formation and elaboration methods for assessment of tumour angiogenesis are still up-dated. Another important concern are different aspects of usage of immunohistochemical markers of blood vessels endothelium (CD31 and CD34) for assessment of tumour aggressiveness and prognosis. The problems of malignant lymphangiogenesis are also up-to-date. The focus is on methods of immunohistochemical visualization of forming lymphatic vessels, role of podoplanin, the most reliable marker of lymphatic vessels, in their identification, and formulization of the main criteria for lymphangiogenesis estimation, its correlation with metastatic activity and prognostic potential. Studying of angiogenesis and lymph angiogenesis in malignant tumors is important and challenging direction for researching tumour progression and invention of antiangiogenic therapy.

Keywords:

angiogenesis

hemangiogenesis

lymphangiogenesis

retraction artifact

tumour

microvascular density

CD34

CD31

podoplanin

VEGF

Authors:

Nefedova N.A.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova"

Kharlova O.A.

Russian Medical Academy of Postgraduate Education, Moscow

Danilova N.V.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava RF;
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Mal'kov P.G.

GUNU "Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova";
GBOU DPO "Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia", Moskva

Gaifullin N.M.

Lomonosov Moscow State University, Moscow, Russia

Close metadata

References:

Gerwins P, Skoldenberg E, Claesson-Welsh L. Function of fibroblast growth factors and vascular endothelial growth factors and their receptors in angiogenesis. Crit Rev Oncol Hematol. 2000;34:185-194.
Ferrara N. VEGF-A: a critical regulator of blood vessel growth. Eur Cytokine Netw. 2009;20:158-163. doi:10.1684/ecn.2009.0170.
Risau W. Mechanisms of angiogenesis. Nature. 1997;386:671-674. doi:10.1038/386671a0.
Takakura N, Watanabe T, Suenobu S et al. A role for hematopoietic stem cells in promoting angiogenesis. Cell. 2000;102:199-209.
Spirina L, Kondakova I, Usynin Y, Vintizenko S. Angiogenesis regulation in renal and bladder cancers. Sibirskii onkologicheskii zhurnal. 2008;4:66-70. (In Russ.)
Morabito A, Sarmiento R, Bonginelli P, Gasparini G. Antiangiogenic strategies, compounds, and early clinical results in breast cancer. Crit Rev Oncol Hematol. 2004;49:91-107. doi:10.1016/s1040-8428(03)00168-9.
Tammela T, Alitalo K. Lymphangiogenesis: Molecular mechanisms and future promise. Cell. 2010;140:460-476. doi:10.1016/j.cell.2010.01.045.
Matsumoto T, Claesson-Welsh L. VEGF receptor signal transduction. Sci STKE. 2001;2001:re21. doi:10.1126/stke.2001.112.re21.
Stepanova E, Lichinitser M, Vartanyan A. Vasculogenic mimicry in malignant tumours. Molekulyarnaya meditsina. 2006;1:23-30. (In Russ.)
Gershtein E, Kushlinskii D, Degtyar' V. Vascular enrothelial growth factor as main regulator of angiogenesis and clinically significant marker in different malignant tumours. Tekhnologii zhivykh sistem. 2013;10:18-33. (In Russ.)
Dua RS, Gui GP, Isacke CM. Endothelial adhesion molecules in breast cancer invasion into the vascular and lymphatic systems. Eur J Surg Oncol. 2005;31:824-832. doi:10.1016/j.ejso.2005.05.015.
Qiao L, Liang N, Zhang J et al. Advanced research on vasculogenic mimicry in cancer. J Cell Mol Med. 2015;19:315-326. doi:10.1111/jcmm.12496.
Folberg R, Maniotis AJ. Vasculogenic mimicry. APMIS. 2004;112:508-525. doi:10.1111/j.1600-0463.2004.apm11207-0810.x.
Folberg R, Hendrix MJ, Maniotis AJ. Vasculogenic mimicry and tumor angiogenesis. Am J Pathol. 2000;156:361-381. doi:10.1016/s0002-9440(10)64739-6.
Yue WY, Chen ZP. Does vasculogenic mimicry exist in astrocytoma? J Histochem Cytochem. 2005;53:997-1002. doi:10.1369/jhc.4A6521.2005.
Brizel DM, Scully SP, Harrelson JM et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 1996;56:941-943.
Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56:4509-4515.
Cao G, O'Brien CD, Zhou Z et al. Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration. Am J Physiol Cell Physiol. 2002;282:C1181-C1190. doi:10.1152/ajpcell.00524.2001.
El-Gendi S, Abdel-Hadi M. Lymphatic vessel density as prognostic factor in breast carcinoma: relation to clinicopathologic parameters. J Egypt Natl Canc Inst. 2009;21:139-149.
Lee SK, Cho EY, Kim WW et al. The prediction of lymph node metastasis in ductal carcinoma in situ with microinvasion by assessing lymphangiogenesis. J Surg Oncol. 2010;102:225-229. doi:10.1002/jso.21607.
Nico B, Benagiano V, Mangieri D, Maruotti N, Vacca A, Ribatti D. Evaluation of microvascular density in tumors: pro and contra. Histol Histopathol. 2008;23:601-607.
Guidi AJ, Berry DA, Broadwater G et al. Association of angiogenesis in lymph node metastases with outcome of breast cancer. J Natl Cancer Inst. 2000;92:486-492.
Nathanson SD. Insights into the mechanisms of lymph node metastasis. Cancer. 2003;98:413-423. doi:10.1002/cncr.11464.
Kaneko MK, Kato Y, Kitano T, Osawa M. Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor. Gene. 2006;378:52-57. doi:10.1016/j.gene.2006.04.023.
Wicki A, Christofori G. The potential role of podoplanin in tumour invasion. Br J Cancer. 2007;96:1-5. doi:10.1038/sj.bjc.6603518.
Van der Auwera I, Cao Y, Tille JC et al. First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer. 2006;95:1611-1625. doi:10.1038/sj.bjc.6603445.
Ramirez MI, Millien G, Hinds A, Cao Y, Seldin DC, Williams MC. T1alpha, a lung type I cell differentiation gene, is required for normal lung cell proliferation and alveolus formation at birth. Dev Biol. 2003;256:61-72.
Gu Y, Qi X, Guo S. Lymphangiogenesis induced by VEGF-C and VEGF-D promotes metastasis and a poor outcome in breast carcinoma: a retrospective study of 61 cases. Clin Exp Metastasis. 2008;25:717-725. doi:10.1007/s10585-008-9180-4.
Agarwal B, Saxena R, Morimiya A, Mehrotra S, Badve S. Lymphangiogenesis does not occur in breast cancer. Am J Surg Pathol. 2005;29:1449-1455.
Chen Y, Yan J, Yuan Z et al. A meta-analysis of the relationship between lymphatic microvessel density and clinicopathological parameters in breast cancer. Bull Cancer. 2013;100:1-10. doi:10.1684/bdc.2013.1719.
Zhao YC, Ni XJ, Li Y et al. Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients. World J Surg Oncol. 2012;10:165. doi:10.1186/1477-7819-10-165.
Beasley NJ, Prevo R, Banerji S et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res. 2002;62:1315-1320.
Hall FT, Freeman JL, Asa SL, Jackson DG, Beasley NJ. Intratumoral lymphatics and lymph node metastases in papillary thyroid carcinoma. Arch Otolaryngol Head Neck Surg. 2003;129:716-719. doi:10.1001/archotol.129.7.716.
Sipos B, Klapper W, Kruse ML, Kalthoff H, Kerjaschki D, Kloppel G. Expression of lymphangiogenic factors and evidence of intratumoral lymphangiogenesis in pancreatic endocrine tumors. Am J Pathol. 2004;165:1187-1197. doi:10.1016/s0002-9440(10)63379-2.
Skobe M, Hawighorst T, Jackson DG et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis. Nat Med. 2001;7:192-198. doi:10.1038/84643.
Padera TP, Kadambi A, di Tomaso E et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002;296:1883-1886. doi:10.1126/science.1071420.
Wong SY, Haack H, Crowley D, Barry M, Bronson RT, Hynes RO. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Res. 2005;65:9789-9798. doi:10.1158/0008-5472.can-05-0901.
Lee K, Park do J, Choe G, Kim HH, Kim WH, Lee HS. Increased intratumoral lymphatic vessel density correlates with lymph node metastasis in early gastric carcinoma. Ann Surg Oncol. 2010;17:73-80. doi:10.1245/s10434-009-0707-y.
Ji RC. Lymphatic endothelial cells, tumor lymphangiogenesis and metastasis: New insights into intratumoral and peritumoral lymphatics. Cancer Metastasis Rev. 2006;25:677-694. doi:10.1007/s10555-006-9026-y.
Matsumoto K, Nakayama Y, Inoue Y et al. Lymphatic microvessel density is an independent prognostic factor in colorectal cancer. Dis Colon Rectum. 2007;50:308-314. doi:10.1007/s10350-006-0792-y.
Zeng Y, Opeskin K, Horvath LG, Sutherland RL, Williams ED. Lymphatic vessel density and lymph node metastasis in prostate cancer. Prostate. 2005;65:222-230. doi:10.1002/pros.20288.
Fiedler U, Christian S, Koidl S et al. The sialomucin CD34 is a marker of lymphatic endothelial cells in human tumors. Am J Pathol. 2006;168:1045-1053. doi:10.2353/ajpath.2006.050554.
Mohammed RA, Ellis IO, Mahmmod AM et al. Lymphatic and blood vessels in basal and triple-negative breast cancers: characteristics and prognostic significance. Mod Pathol. 2011;24:774-785. doi:10.1038/modpathol.2011.4.
Acs G, Dumoff KL, Solin LJ, Pasha T, Xu X, Zhang PJ. Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma. Am J Surg Pathol. 2007;31:129-140. doi:10.1097/01.pas.0000213316.59176.9b.
Acs G, Paragh G, Rakosy Z, Laronga C, Zhang PJ. The extent of retraction clefts correlates with lymphatic vessel density and VEGF-C expression and predicts nodal metastasis and poor prognosis in early-stage breast carcinoma. Mod Pathol. 2012;25:163-177. doi:10.1038/modpathol.2011.138.
Senchukova M, Kiselevsky MV. The «cavitary» type of angiogenesis by gastric cancer. Morphological characteristics and prognostic value. J Cancer. 2014;5(5):311-319. doi:10.7150/jca.8716.

Log in to the site using your account in one of the services

Registration

Last Name

Name

Middle Name

E-mail

Phone

Address

Country

Zip

City

Region

Street

Home

Apartmen

Legal entity name

ИНН

КПП

Password

Password

Repeat password

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.