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Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Sekacheva M.I.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Fedorov D.N.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Skipenko O.G.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. B.V. Petrovskogo RAMN, Moskva

Impact of preoperative chemotherapy on the expression of apoptosis factors in colorectal cancer liver metastases

Authors:

Pal'tseva E.M., Sekacheva M.I., Fedorov D.N., Skipenko O.G.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2014;76(4): 18‑23

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To cite this article:

Pal'tseva EM, Sekacheva MI, Fedorov DN, Skipenko OG. Impact of preoperative chemotherapy on the expression of apoptosis factors in colorectal cancer liver metastases. Russian Journal of Archive of Pathology. 2014;76(4):18‑23. (In Russ.)

Подписка 2025 (Russian Journal of Archive of Pathology)
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Objective - to study the effects of cytotoxic and targeted anti-VEGF drugs on some mechanisms of apoptosis. Material and methods. The effects of cytotoxic and targeted anti-VEGF drugs on the expression of the apoptosis activators Bax and PML and the apoptosis inhibitor Bcl-2 were studied in the colorectal cancer (CRC) liver metastases; a comparison group comprised patients receiving no chemotherapy. Results. Immunohistochemical examination revealed lower Bax and PML expressions and higher Bcl-2 expression in the majority of untreated patients, suggesting the suppressed mechanisms triggering tumor cell apoptosis. Cytotoxic therapy resulted in a statistically significant rise in the expression of the apoptosis activator Bax (p=0.01), a reduction in the level of the apoptosis inhibitor Bcl-2 (р=0.04) and a slight increase in PML that controlled the induction of apoptosis. Adding an anti-VEGF agent to cytotoxic therapy exerted no statistically significant impact on Bax and Bcl-2, but caused more frequent positive PML expression than in the control and cytotoxic chemotherapy groups. Conclusion. Our study showed that cytotoxic and targeted anti-VEGF agents activate the apoptosis of tumor cells in the CRC liver metastases.

Keywords:

metastatic colorectal cancer
apoptosis
Bax
Bcl-2
PML
cytotoxic agents
VEGF

Authors:

Pal'tseva E.M.

Laboratoriia élektronnoĭ mikroskopii i immunogistokhimii Tsentralizovannogo patologoanatomicheskogo otdeleniia GBOU VPO "Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova" Minzdravsotsrazvitiia Rossii

Sekacheva M.I.

Otdelenie khirurgii pecheni, zhelchnykh puteĭ i podzheludochnoĭ zhelezy Rossiĭskogo nauchnogo tsentra khirurgii im. akad. B.V. Petrovskogo RAMN, Moskva

Fedorov D.N.

RNTsKh im. akad. B.V. Petrovskogo RAMN, Moskva

Skipenko O.G.

Rossiĭskiĭ nauchnyĭ tsentr khirurgii im. B.V. Petrovskogo RAMN, Moskva

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