Blood purification using CytoSorb device has become widespread in modern intensive care for septic shock and sepsis-associated acute kidney injury, as well as severe COVID-19 accompanied by severe hypercytokinemia. At the same time, effectiveness of CytoSorb in patients with severe hepatic failure is less clear in modern literature. Available data indicate high detoxification potential of CytoSorb in relation to the main «liver» factors of endogenous intoxication (bilirubin, bile acids, ammonia). Inclusion of CytoSorb cytokine adsorber in intensive therapy may be effective for acute liver failure due to correction of endogenous intoxication. This effect allows regression of clinical manifestations and probably contributes to compensation of liver dysfunction. The authors report successful blood purification in a patient with irreversible liver failure until orthotopic liver transplantation. This approach created conditions for relief of early transplant dysfunction. Considering simplicity and relatively low cost compared to other extracorporeal methods of liver function support, we can emphasize that CytoSorb cytokine adsorber appears to be perspective for intensive therapy in patients with severe liver failure.