Personalized Airway Pressure Release Ventilation for acute respiratory distress syndrome: pathophysiological rationale, clinical trials and application prospects

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Airway pressure release ventilation (APRV) differs from the conventional ventilation modes due to a significant inversion of the inspiratory to expiratory ratio. This mode is recommended for acute respiratory distress syndrome if the «traditional» approach is not effective. In recent years, ventilation strategy with APRV has significantly changed based and new physiological approach was justified. Various modes of APRV, respiratory physiology during ventilation in this mode, its effect on ventilator-induced lung injury and current evidence on the use of APRV for ARDS are reported in the article.

Keywords:

mechanical ventilation

airway pressure release ventilation

APRV

acute respiratory distress syndrome

ventilator-induced lung injury

Authors:

Savelenok M.I.

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia;
Regional Clinical Hospital for Emergency Care, Barnaul, Russia

Yaroshetsky A.I.

FGBOU VO «Russian national research medical University named after N.I. Pirogov» of Ministry of health of Russia, Moscow, Russia

SPIN RSCI: 3057-5690
Scopus AuthorID: 57194422657
ResearcherID: AAM-6373-2021
ORCID: 0000-0002-1484-092X

Raikin I.D.

Altai State Medical University of the Ministry of Health of Russia, Barnaul, Russia

Konanykhin V.D.

Pirogov Russian National Research Medical University of the Ministry of Health of Russia, Moscow, Russia

Zakharchenko I.A.

Regional Clinical Hospital for Emergency Care, Barnaul, Russia

List of references:

Habashi NM. Other approaches to open-lung ventilation: airway pressure release ventilation. Critical Care Medicine. 2005;33(3 Suppl):S228-240.
Stock MC, Downs JB, Frolicher DA. Airway pressure release ventilation. Critical Care Medicine. 1987;15(5):462-466.
Bein T, Wrigge H. Airway pressure release ventilation (APRV): Do good things come to those who can wait? Journal of Thoracic Disease. 2018;10(2):667-669. https://doi.org/10.21037/jtd.2018.01.107
Davis K, Johnson DJ, Branson RD, Campbell RS. Airway pressure release ventilation. Archives of Surgery. 1993;128(12):1348-1352.
Gama de Abreu M, Cuevas M, Spieth PM, Carvalho AR, Hietschold V, Stroszczynski C, Wiedemann B, Koch T, Pelosi P, Koch E. Regional lung aeration and ventilation during pressure support and biphasic positive airway pressure ventilation in experimental lung injury. Critical Care. 2010;14(2):R34.
Andrews PL, Shiber JR, Jaruga-Killeen E, Roy S, Sadowitz B, O’Toole RV, Gatto LA, Nieman GF, Scalea T, Habashi NM. Early application of airway pressure release ventilation may reduce mortality in high-risk trauma patients: a systematic review of observational trauma ARDS literature. Journal of Trauma and Acute Care Surgery. 2013;75(4):635-641. https://doi.org/10.1097/TA.0b013e31829d3504
Jain SV, Kollisch-Singule M, Sadowitz B, Dombert L, Satalin J, Andrews P, Gatto LA, Nieman GF, Habashi NM. The 30-year evolution of airway pressure release ventilation (APRV). Intensive Care Medicine Experimental. 2016;4(1):11. https://doi.org/10.1186/s40635-016-0085-2
Kollisch-Singule M, Andrews P, Satalin J, Gatto LA, Nieman GF, Habashi NM. The time-controlled adaptive ventilation protocol: mechanistic approach to reducing ventilator-induced lung injury. European Respiratory Review. 2019;28(152):180126. https://doi.org/10.1183/16000617.0126-2018
Kollisch-Singule M, Emr B, Smith B, Roy S, Jain S, Satalin J, Snyder K, Andrews P, Habashi N, Bates J, Marx W, Nieman G, Gatto LA. Mechanical breath profile of airway pressure release ventilation: the effect on alveolar recruitment and microstrain in acute lung injury. JAMA Surgery. 2014;149(11):1138-1145. https://doi.org/10.1001/jamasurg.2014.1829
Andrews P, Satalin J, Wilcox K, Kollisch-Singule M, Madden M, Aiash H, Blair SJ, Gatto LA, Habashi NM. Acute lung injury: how to stabilize a broken lung. Critical Care. 2018;22(1):136. https://doi.org/10.1186/s13054-018-2051-8
Melo e Silva CA, Ventura CE. A simple model illustrating the respiratory system’s time constant concept. Advances in Physiology Education. 2006;30(3):129-130.
Silva PL, Cruz FF, Samary CDS, Moraes L, de Magalhães RF, Fernandes MVS, Bose R, Pelegati VB, Carvalho HF, Capelozzi VL, Satalin J, Gatto L, Andrews P, Habashi N, Nieman G, Rocco PRM. Biological Response to Time-Controlled Adaptive Ventilation Depends on Acute Respiratory Distress Syndrome Etiology. Critical Care Medicine. 2018;46(6):e609-617. https://doi.org/10.1097/CCM.0000000000003078
Gritsan AI, Yaroshetskiy AI, Vlasenko AV, Gavrilin SV, Gelfand BR, Zabolotskikh IB, Eremenko AA, Silber AP, Kassil VL, Kirov MYu, Kolesnichenko AP, Lebedinsky KM, Leiderman IN, Mazurok VA, Moroz VV, Neymark MI, Nikolaenko EM, Protsenko DN, Rudnov VA, Sadchikov DV, Sadritdinov MA, Solodov AA, Khrapov KN, Tsarenko SV. Diagnosis and intensive care of acute respiratory distress syndrome. Clinical guidelines. Anesteziologiya i reanimatologiya. 2016;61(1):62-70. (In Russ.)
Bates JHT, Irvin CG. Time dependence of recruitment and derecruitment in the lung: a theoretical model. Journal of Applied Physiology. 2002;93(2):705-713.
Alencar AM, Buldyrev SV, Majumdar A, Stanley HE, Suki B. Avalanche dynamics of crackle sound in the lung. Physical Review Letters. 2001;87(8): 088101.
Crotti S, Mascheroni D, Caironi P, Pelosi P, Ronzoni G, Mondino M, Marini JJ, Gattinoni L. Recruitment and derecruitment during acute respiratory failure: A clinical study. American Journal of Respiratory and Critical Care Medicine. 2001;164(1):131-140.
Pelosi P, Goldner M, McKibben A, Adams A, Eccher G, Caironi P, Losappio S, Gattinoni L, Marini JJ. Recruitment and derecruitment during acute respiratory failure. American Journal of Respiratory and Critical Care Medicine. 2001;164(1):122-130.
Hickling KG. The pressure-volume curve is greatly modified by recruitment: A mathematical model of ards lungs. American Journal of Respiratory and Critical Care Medicine. 1998;158(1):194-202.
Gattinoni L, Caironi P, Pelosi P, Goodman LR. What has computed tomography taught us about the acute respiratory distress syndrome? American Journal of Respiratory and Critical Care Medicine. 2001;164(9):1701-1711.
Ghadiali S, Huang Y. Role of airway recruitment and derecruitment in lung injury. Review. Critical Reviews in Biomedical Engineering. 2011;39(4):297-317.
Putensen C, Rasanen J, Lopez FA, Downs JB. Effect of interfacing between spontaneous breathing and mechanical cycles on the ventilation-perfusion distribution in canine lung injury. Anesthesiology. 1994;81(4):921-930.
Putensen C, Räsänen J, López FA. Ventilation-perfusion distributions during mechanical ventilation with superimposed spontaneous breathing in canine lung injury. American Journal of Respiratory and Critical Care Medicine. 1994;150(1):101-108.
Putensen C, Zech S, Wrigge H, Zinserling J, Stüber F, Von Spiegel T, Mutz N. Long-term effects of spontaneous breathing during ventilatory support in patients with acute lung injury. American Journal of Respiratory and Critical Care Medicine. 2001;164(1):43-49.
Valentine DD, Hammond MD, Downs JB, Downs JB, Sears NJ, Sims WR. Distribution of ventilation and perfusion with different modes of mechanical ventilation. The American Review of Respiratory Disease. 1991;143(6):1262-1266.
Mercat A, Diehl JL, Michard F, Anguel N, Teboul JL, Labrousse J, Richard C. Extending inspiratory time in acute respiratory distress syndrome. Critical Care Medicine. 2001;29(1):40-44.
Fuleihan SF, Wilson RS, Pontoppidan H. Effect of mechanical ventilation with end-inspiratory pause on blood-gas exchange. Anesthesia and Analgesia. 1976;55(1):122-130.
Knelson JH, Howatt WF, DeMuth GR. Effect of respiratory pattern on alveolar gas exchange. Journal of Applied Physiology. 1970;29(3):328-331.
Cole AG, Weller SF, Sykes MK. Inverse ratio ventilation compared with PEEP in adult respiratory failure. Intensive Care Med. 1984;10(5):227-232.
Rose GL, Cassidy SS, Johnson RL. Diffusing capacity at different lung volumes during breath holding and rebreathing. Journal of Applied Physiology. 1979;47(1):32-36.
Haycraft JB, Edie R. The Cardiopneumatic Movements. Journal of Physiology. 1891;12(5-6):426-437.
Fukuchi Y, Roussos CS, Macklem PT, Engel LA. Convection, diffusion and cardiogenic mixing of inspired gas in the lung; an experimental approach. Respiration Physiology. 1976;26(1):77-90.
Fredberg JJ. Augmented diffusion in the airways can support pulmonary gas exchange. Journal of Applied Physiology. 1980;49(2):232-238.
Engel LA, Menkes H, Wood LD, Utz G, Joubert J, Macklem PT. Gas mixing during breath holding studied by intrapulmonary gas sampling. Journal of Applied Physiology. 1973;35(1):9-17.
Wrigge H, Zinserling J, Neumann P, Muders T, Magnusson A, Putensen C, Hedenstierna G. Spontaneous breathing with airway pressure release ventilation favors ventilation in dependent lung regions and counters cyclic alveolar collapse in oleic-acid-induced lung injury: a randomized controlled computed tomography trial. Critical Care. 2005;9(6):R780-789.
Neumann P, Wrigge H, Zinserling J, Hinz J, Maripuu E, Andersson LG, Putensen C, Hedenstierna G. Spontaneous breathing affects the spatial ventilation and perfusion distribution during mechanical ventilatory support. Critical Care Medicine. 2005;33(5):1090-1095.
Wrigge H, Zinserling J, Neumann P, Defosse J, Magnusson A, Putensen C, Hedenstierna G. Spontaneous breathing improves lung aeration in oleic acid-induced lung injury. Anesthesiology. 2003;99(2):376-84.
Katz JA, Marks JD. Inspiratory work with and without continuous positive airway pressure in patients with acute respiratory failure. Anesthesiology. 1985;63(6):598-607.
Zhou Y, Jin X, Lv Y, Wang P, Yang Y, Liang G, Wang B, Kang Y. Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome. Intensive Care Med. 2017;43(11):1648-1659. https://doi.org/10.1007/s00134-017-4912-z
Gallagher TJ, Banner MJ. Mean airway pressure as a determinant of oxygenation. Critical Care Medicine. 1980;8(4):396-399.
Tremblay L, Valenza F, Ribeiro SP, Li J, Slutsky AS. Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model. Journal of Clinical Investigation. 1997;99(5):944-952.
Ignatenko OV, Protsenko DN, Yaroshetskiy AI, Gelfand BR. The damaging effect of different modes of mechanical ventilation on lung function in patients with severe trauma. Vestnik anesteziologii i reanimatologii. 2009;6(4):16-21. (In Russ.)
Gattinoni L, Tonetti T, Cressoni M, Cadringher P, Herrmann P, Moerer O, Protti A, Gotti M, Chiurazzi C, Carlesso E, Chiumello D, Quintel M. Ventilator-related causes of lung injury: the mechanical power. Intensive Care Medicine. 2016;42(10).
Curley GF, Laffey JG, Zhang H, Slutsky AS. Biotrauma and Ventilator-Induced Lung Injury Clinical Implications. Chest. 2016;150(5):1109-1117. https://doi.org/10.1016/j.chest.2016.07.019
Lang JD, McArdle PJ, O’Reilly PJ, Matalon S. Oxidant-antioxidant balance in acute lung injury. Chest. 2002;122(6 Suppl):314-320.
Ware LB, Matthay MA. The Acute Respiratory Distress Syndrome. New England Journal of Medicine. 2000;342(18):1334-1349.
Montgomery AB, Stager MA, Carrico CJ, Hudson LD. Causes of mortality in patients with the adult respiratory distress syndrome. The American Review of Respiratory Disease. 1985;132(3):485-489.
Imai Y, Parodo J, Kajikawa O, de Perrot M, Fischer S, Edwards V, Cutz E, Liu M, Keshavjee S, Martin TR, Marshall JC, Ranieri VM, Slutsky AS. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA. 2003;289(16):2104-2112.
Schwartz MD, Moore EE, Moore FA, Shenkar R, Moine P, Haenel JB, Abraham E. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Critical Care Medicine. 1996;24(8):1285-1292.
Ignatenko OV, Procenko DN, Yarosheckij AI, Gel’fand BR. Ventilyator-associirovannoe povrezhdenie legkih. V kn.: Ostryj respiratornyj distress-sindrom. Pod red.: BR Gel’fanda, VL Kassilya. M.: «Literra»; 2007: 114-126. (In Russ.)
Yarosheckij AI. Respiratornaya terapiya. V kn.: Intensivnaya terapiya. Nacional’noe rukovodstvo. Pod red. B.R. Gel’fanda, A.I. Saltanova. GEOTAR-Media; 2009: 449-473. (In Russ.)
Roy S, Sadowitz B, Andrews P, Shenkar R, Moine P, Haenel JB, Abraham E. Early stabilizing alveolar ventilation prevents acute respiratory distress syndrome: a novel timing-based ventilatory intervention to avert lung injury. Journal of Trauma and Acute Care Surgery. 2012;73(2):391-400.
Emr B, Gatto LA, Roy S, Satalin J, Ghosh A, Snyder K, Andrews P, Habashi N, Marx W, Ge L, Wang G, Dean DA, Vodovotz Y, Nieman G.Airway pressure release ventilation prevents ventilator-induced lung injury in normal lungs. JAMA Surgery. 2013;148(11):1005-1012. https://doi.org/10.1001/jamasurg.2013.3746
Oeckler RA, Hubmayr RD. Alveolar microstrain and the dark side of the lung. Critical Care. 2007;11(6):177.
Protti A, Andreis DT, Monti M, Santini A, Sparacino CC, Langer T, Votta E, Gatti S, Lombardi L, Leopardi O, Masson S, Cressoni M, Gattinoni L. Lung stress and strain during mechanical ventilation: any difference between statics and dynamics? Critical Care Medicine. 2013;41(4):1046-1055. https://doi.org/10.1097/CCM.0b013e31827417a6
Hubmayr RD, Rodarte JR, Walters BJ, Tonelli FM. Regional ventilation during spontaneous breathing and mechanical ventilation in dogs. Journal of Applied Physiology. 1987;63(6):2467-2475.
Chiumello D, Carlesso E, Cadringher P, Caironi P, Valenza F, Polli F, Tallarini F, Cozzi P, Cressoni M, Colombo A, Marini JJ, Gattinoni L. Lung stress and strain during mechanical ventilation for acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 2008;178(4):346-355. https://doi.org/10.1164/rccm.200710-1589OC
Chiumello D. Transpulmonary pressure: A more pathophysiological open lung approach? Critical Care Medicine. 2012;40(7):2249-2250.
Chiumello D, Cressoni M, Colombo A, Babini G, Brioni M, Crimella F, Lundin S, Stenqvist O, Gattinoni L. The assessment of transpulmonary pressure in mechanically ventilated ARDS patients. Intensive Care Medicine. 2014;40(11):1670-1678. https://doi.org/10.1007/s00134-014-3415-4
Akoumianaki E, Maggiore SM, Valenza F, Bellani G, Jubran A, Loring SH, Pelosi P, Talmor D, Grasso S, Chiumello D, Guérin C, Patroniti N, Ranieri VM, Gattinoni L, Nava S, Terragni PP, Pesenti A, Tobin M, Mancebo J, Brochard L; PLUG Working Group (Acute Respiratory Failure Section of the European Society of Intensive Care Medicine). The application of esophageal pressure measurement in patients with respiratory failure. American Journal of Respiratory and Critical Care Medicine. 2014;189(5):520-531. https://doi.org/10.1164/rccm.201312-2193CI
Ranieri VM, Suter PM, Tortorella C, De Tullio R, Dayer JM, Brienza A, Bruno F, Slutsky AS. Effect of mechanical ventilation on inflammatory mediators in patients with acute respiratory distress syndrome: a randomized controlled trial. JAMA. 1999;282(1):54-61.
Brunner JX, Wysocki M. Is there an optimal breath pattern to minimize stress and strain during mechanical ventilation? Intensive Care Medicine. 2009;35(8):1479-1483.
Gattinoni L, Carlesso E, Langer T. Towards ultraprotective mechanical ventilation. Current Opinion in Anaesthesiology. 2012;25(2):141-147.
Rausch SMK, Haberthür D, Stampanoni M, Schittny JC, Wall WA. Local strain distribution in real three-dimensional alveolar geometries. Annals of Biomedical Engineering. 2011;39(11):2835-2843. https://doi.org/10.1007/s10439-011-0328-z
Mead J, Takishima T, Leith D. Stress distribution in lungs: a model of pulmonary elasticity. Journal of Applied Physiology. 1970;28(5):596-608.
Bates JHT, Davis GS, Majumdar A, Butnor KJ, Suki B. Linking parenchymal disease progression to changes in lung mechanical function by percolation. American Journal of Respiratory and Critical Care Medicine. 2007;176(6):617-623.
Marini JJ, Gattinoni L. Energetics and the Root Mechanical Cause for Ventilator-induced Lung Injury. Anesthesiology. 2018;128(6):1062-1064.
Nieman GF, Satalin J, Andrews P, Habashi NM, Gatto LA. Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI). Intensive Care Medicine Experimental. 2016;4(1):16. https://doi.org/10.1186/s40635-016-0090-5
Gattinoni L, Tonetti T, Quintel M. Regional physiology of ARDS. Critical Care. 2017;21(Suppl 3):312. https://doi.org/10.1186/s13054-017-1905-9
Marini JJ. Strain Rate and Cycling Frequency — the «Dynamic Duo» of Injurious Tidal Stress. Critical Care Medicine. 2016;44(9):1800-1801.
Amato MBP, Meade MO, Slutsky AS, Brochard L, Costa EL, Schoenfeld DA, Stewart TE, Briel M, Talmor D, Mercat A, Richard JC, Carvalho CR, Brower RG. Driving pressure and survival in the acute respiratory distress syndrome. New England Journal of Medicine. 2015;372(8):747-755. https://doi.org/10.1056/NEJMsa1410639
Tschumperlin DJ, Oswari J, Margulies SS. Deformation-induced injury of alveolar epithelial cells: Effect of frequency, duration, and amplitude. American Journal of Respiratory and Critical Care Medicine. 2000;162(2 I):357-362.
Nikolaenko EM, Belikov SM, Volkova MI, Ivanov EV, Kajnov MS, Soltan SA, Stepanov NA, Marchenkov YuV, Figurova LM, Fomicheva AV. Ventilation des poumons, réglable en pression, avec un rapport inverse de la durée des phases d’inspiration et d’expiration. 1996;1:43-48. Anesteziologiya i reanimatologiya. (In Russ.)
Daoud EG, Farag HL, Chatburn RL. Airway pressure release ventilation: what do we know? Respiratory Care. 2012;57(2):282-292.
Henzler D. What on earth is APRV? Critical Care. 2011;15(1):115. https://doi.org/10.1186/cc9419
Mireles-Cabodevila E, Dugar S, Chatburn RL. APRV for ARDS: The complexities of a mode and how it affects even the best trials. Journal of Thoracic Disease. 2018;10(Suppl 9):S1058-1063.
Roy SK, Emr B, Sadowitz B, Gatto LA, Ghosh A, Satalin JM, Snyder KP, Ge L, Wang G, Marx W, Dean D, Andrews P, Singh A, Scalea T, Habashi N, Nieman GF. Preemptive application of airway pressure release ventilation prevents development of acute respiratory distress syndrome in a rat traumatic hemorrhagic shock model. Shock. 2013;40(3):210-216. https://doi.org/10.1097/SHK.0b013e31829efb06
Roy S, Habashi N, Sadowitz B, Andrews P, Ge L, Wang G, Roy P, Ghosh A, Kuhn M, Satalin J, Gatto LA, Lin X, Dean DA, Vodovotz Y, Nieman G. Early airway pressure release ventilation prevents ARDS-a novel preventive approach to lung injury. Shock. 2013;39(1):28-38.
Kaplan LJ, Bailey H, Formosa V. Airway pressure release ventilation increases cardiac performance in patients with acute lung injury/adult respiratory distress syndrome. Critical Care. 2001;5(4):221-226.
Kamath SS, Super DM, Mhanna MJ. Effects of airway pressure release ventilation on blood pressure and urine output in children. Pediatric Pulmonology. 2010;45(1):48-54.
Varpula T, Valta P, Niemi R, Takkunen O, Hynynen M, Pettilä VV. Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome. Acta Anaesthesiologica Scandinavica. 2004;48(6):722-731.
Putensen C, Mutz NJ, Putensen-Himmer G, Zinserling J. Spontaneous breathing during ventilatory support improves ventilation-perfusion distributions in patients with acute respiratory distress syndrome. American Journal of Respiratory and Critical Care Medicine. 1999;159(4 Pt 1):1241-1248.
Li J-Q, Li N, Han G-J, Pan CG, Zhang YH, Shi XZ, Xu JY, Lu B, Li MQ. Clinical research about airway pressure release ventilation for moderate to severe acute respiratory distress syndrome. European Review for Medical and Pharmacological Sciences. 2016;20(12):2634-2641.
Räsänen J, Downs JB, Stock MC. Cardiovascular effects of conventional positive pressure ventilation and airway pressure release ventilation. Chest. 1988;93(5):911-915.
Henzler D, Dembinski R, Bensberg R, Hochhausen N, Rossaint R, Kuhlen R. Ventilation with biphasic positive airway pressure in experimental lung injury. Influence of transpulmonary pressure on gas exchange and haemodynamics. Intensive Care Medicine. 2004;30(5):935-943.
Hering R, Viehöfer A, Zinserling J, Wrigge H, Kreyer S, Berg A, Minor T, Putensen C. Effects of spontaneous breathing during airway pressure release ventilation on intestinal blood flow in experimental lung injury. Anesthesiology. 2003;99(5):1137-1144.
Hering R, Bolten JC, Kreyer S, Berg A, Wrigge H, Zinserling J, Putensen C. Spontaneous breathing during airway pressure release ventilation in experimental lung injury: effects on hepatic blood flow. Intensive Care Medicine. 2008;34(3):523-527.
Hering R, Peters D, Zinserling J, Wrigge H, von Spiegel T, Putensen C. Effects of spontaneous breathing during airway pressure release ventilation on renal perfusion and function in patients with acute lung injury. Intensive Care Medicine. 2002;28(10):1426-1433.
Kreyer S, Putensen C, Berg A, Soehle M, Muders T, Wrigge H, Zinserling J, Hering R. Effects of spontaneous breathing during airway pressure release ventilation on cerebral and spinal cord perfusion in experimental acute lung injury. J Neurosurg Anesthesiol. 2010;22(4):323-329. https://doi.org/10.1097/ANA.0b013e3181e775f1
Mekontso Dessap A, Boissier F, Charron C, Charron C, Bégot E, Repessé X, Legras A, Brun-Buisson C, Vignon P, Vieillard-Baron A. Acute cor pulmonale during protective ventilation for acute respiratory distress syndrome: prevalence, predictors, and clinical impact. Intensive Care Medicine. 2016;42(5):862-870. https://doi.org/10.1007/s00134-015-4141-2
Writing Group for the Alveolar Recruitment for Acute Respiratory Distress Syndrome Trial (ART) Investigators, Cavalcanti AB, Suzumura ÉA, Laranjeira LN, Paisani DM, Damiani LP, Guimarães HP, Romano ER, Regenga MM, Taniguchi LNT, Teixeira C, Pinheiro de Oliveira R, Machado FR, Diaz-Quijano FA, Filho MSA, Maia IS, Caser EB, Filho WO, Borges MC, Martins PA, Matsui M, Ospina-Tascón GA, Giancursi TS, Giraldo-Ramirez ND, Vieira SRR, Assef MDGPL, Hasan MS, Szczeklik W, Rios F, Amato MBP, Berwanger O, Ribeiro de Carvalho CR. Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome. JAMA. 2017;318(14):1335. https://doi.org/10.1001/jama.2017.14171
Marini JJ, Jaber S. Dynamic predictors of VILI risk: beyond the driving pressure. Intensive Care Medicine. 2016;42(10):1597-1600.
Gattinoni L, Marini JJ, Collino F, Maiolo G, Rapetti F, Tonetti T, Vasques F, Quintel M.The future of mechanical ventilation: Lessons from the present and the past. Critical Care. 2017;21(1):183.
Rathgeber J, Schorn B, Falk V, Kazmaier S, Spiegel T, Burchardi H. The influence of controlled mandatory ventilation (CMV), intermittent mandatory ventilation (IMV) and biphasic intermittent positive airway pressure (BIPAP) on duration of intubation and consumption of analgesics and sedatives. A prospective analysis in 596 patients following adult cardiac surgery. European Journal of Anesthesiology. 1997;14(6):576-582.
Walkey AJ, Nair S, Papadopoulos S, Agarwal S, Reardon CC. Use of airway pressure release ventilation is associated with a reduced incidence of ventilator-associated pneumonia in patients with pulmonary contusion. Journal of Trauma. 2011;70(3):E42-47. https://doi.org/10.1097/TA.0b013e3181d9f612
O’Donoghue FJ, Catcheside PG, Jordan AS, Bersten AD, McEvoy RD. Effect of CPAP on intrinsic PEEP, inspiratory effort, and lung volume in severe stable COPD. Thorax. 2002;57(6):533-539.
Schlobohm RM, Falltrick RT, Quan SF, Katz JA. Lung volumes, mechanics, and oxygenation during spontaneous positive-pressure ventilation: the advantage of CPAP over EPAP. Anesthesiology. 1981;55(4):416-422.
Morais CC, Koyama Y, Yoshida T, Plens GM, Gomes S, Lima CL, Ramos OP, Pereira SM, Kawaguchi N, Yamamoto H, Uchiyama A, Borges JB, Vidal Melo MF, Tucci MR, Amato MBP, Kavanagh BP, Costa ELV FY. High Positive End-Expiratory Pressure Renders Spontaneous Effort Non-Injurious American journal of respiratory and critical care medicine. American Journal of Respiratory and Critical Care Medicine. 2018;Jan 11.
Vovk A, Binks AP. Raising end-expiratory volume relieves air hunger in mechanically ventilated healthy adults. Journal of Applied Physiology. 2007;103(3):779-786.
Yoshida T, Torsani V, Gomes S, De Santis RR, Beraldo MA, Costa EL, Tucci MR, Zin WA, Kavanagh BP, Amato MB. Spontaneous effort causes occult pendelluft during mechanical ventilation. American Journal of Respiratory and Critical Care Medicine. 2013;188(12):1420-1427. https://doi.org/10.1164/rccm.201303-0539OC
Yoshida T, Roldan R, Beraldo MA, Torsani V, Gomes S, De Santis RR, Costa EL, Tucci MR, Lima RG, Kavanagh BP, Amato MB. Spontaneous effort during mechanical ventilation: Maximal injury with less positive end-expiratory pressure. Critical Care Medicine. 2016;44(8):e678-88. https://doi.org/10.1097/CCM.0000000000001649
Yoshida T, Uchiyama A, Matsuura N, Mashimo T, Fujino Y. Spontaneous breathing during lung-protective ventilation in an experimental acute lung injury model. Critical Care Medicine. 2012;40(5):1578-1585. https://doi.org/10.1097/CCM.0b013e3182451c40
Yaroshetskiy AI, Protsenko DN, Rezepov NA, Gelfand BR. Positive end-expiratory pressure adjustment in parenchimal respiratory failure: static pressure-volume loop or transpulmonary pressure? Anesteziologiya i reanimatologiya. 2014;59(4):53-59. (In Russ.)
Kallet RH, Hemphill JC, Dicker RA, Dicker RA, Alonso JA, Campbell AR, Mackersie RC, Katz JA. The spontaneous breathing pattern and work of breathing of patients with acute respiratory distress syndrome and acute lung injury. Respiratory Care. 2007;52(8):989-995.
Kallet RH, Alonso JA, Luce JM, Matthay MA. Exacerbation of acute pulmonary edema during assisted mechanical ventilation using a low-tidal volume, lung-protective ventilator strategy. Chest. 1999;116(6):1826-1832.
Road JD, Leevers AM, Goldman E, Grassino A. Respiratory muscle coordination and diaphragm length during expiratory threshold loading. Journal of Applied Physiology. 1991;70(4):1554-1562.
Leevers AM, Road JD. Mechanical response to hyperinflation of the two abdominal muscle layers. Journal of Applied Physiology. 1989;66(5):2189-2195.
Farkas GA, Schroeder MA. Mechanical role of expiratory muscles during breathing in prone anesthetized dogs. Journal of Applied Physiology. 1990;69(6):2137-2142.
Calzia E, Lindner KH, Witt S, Schirmer U, Lange H, Stenz R, Georgieff M. Pressure-time product and work of breathing during biphasic continuous positive airway pressure and assisted spontaneous breathing. American Journal of Respiratory and Critical Care Medicine. 1994;150(4):904-910.
Chiang AA, Steinfeld A, Gropper C, MacIntyre N. Demand-flow airway pressure release ventilation as a partial ventilatory support mode: comparison with synchronized intermittent mandatory ventilation and pressure support ventilation. Critical Care Medicine. 1994;22(9):1431-1437.
Henzler D, Pelosi P, Bensberg R, Dembinski R, Quintel M, Pielen V, Rossaint R, Kuhlen R. Effects of partial ventilatory support modalities on respiratory function in severe hypoxemic lung injury. Critical Care Medicine. 2006;34(6):1738-1745.
Neumann P, Golisch W, Strohmeyer A, Buscher H, Burchardi H, Sydow M. Influence of different release times on spontaneous breathing pattern during airway pressure release ventilation. Intensive Care Medicine. 2002;28(12):1742-1749.
Myers TR, MacIntyre NR. Respiratory controversies in the critical care setting. Does airway pressure release ventilation offer important new advantages in mechanical ventilator support? Respiratory Care. 2007;52(4):452-458.
Uyar M, Demirag K, Olgun E, Cankayali I, Moral AR. Comparison of oxygen cost of breathing between pressure-support ventilation and airway pressure release ventilation. Anaesth Intensive Care. 2005;33(2):218-222.
Gherini S, Peters RM, Virgilio RW. Mechanical work on the lungs and work of breathing with positive end-expiratory pressure and continuous positive airway pressure. Chest. 1979;76(3):251-256.
Chandra A, Coggeshall JW, Ravenscraft SA, Marini JJ. Hyperpnea limits the volume recruited by positive end-expiratory pressure. American Journal of Respiratory and Critical Care Medicine. 1994;150(4):911-917.
Cressoni M, Gotti M, Chiurazzi C, Massari D, Algieri I, Amini M, Cammaroto A, Brioni M, Montaruli C, Nikolla K, Guanziroli M, Dondossola D, Gatti S, Valerio V, Vergani GL, Pugni P, Cadringher P, Gagliano N, Gattinoni L. Mechanical Power and Development of Ventilator-induced Lung Injury. Anesthesiology. 2016;124(5):1100-1108. https://doi.org/10.1097/ALN.0000000000001056
Collino F, Rapetti F, Vasques F, Maiolo G, Tonetti T, Romitti F, Niewenhuys J, Behnemann T, Camporota L, Hahn G, Reupke V, Holke K, Herrmann P, Duscio E, Cipulli F, Moerer O, Marini JJ, Quintel M, Gattinoni L. Positive End-expiratory Pressure and Mechanical Power. Anesthesiology. 2019;130(1):119-130. https://doi.org/10.1097/ALN.0000000000002458
Kallet RH. Patient-ventilator interaction during acute lung injury, and the role of spontaneous breathing: part 2: airway pressure release ventilation. Respiratory Care. 2011;56(2):190-203.
Banner MJ, Jaeger MJ, Kirby RR. Components of the work of breathing and implications for monitoring ventilator-dependent patients. Critical Care Medicine. 1994;22:515-523.
Taylor D, Camporota L, Zhou Y, Kang Y. Estimation of true driving pressure during airway pressure release ventilation : Discussion on «Early application of airway pressure release ventilation may reduce the duration of mechanical ventilation in acute respiratory distress syndrome». Intensive Care Medicine. 2018;44(8):1364-1365. https://doi.org/10.1007/s00134-018-5250-5
Kenny J-ES. Driving Pressure in Airway Pressure Release Ventilation: a fool’s errand? PulmCCM. 2018. Available at: https://pulmccm.org/ards-review/driving-pressure-in-airway-pressure-release-ventilation-a-fools-errand/Accessed October 20, 2019.
Tonetti T, Vasques F, Rapetti F, et al. A driving pressure and mechanical power: New targets for VILI prevention. Annals of Translational Medicine. 2017;5(14):286. https://doi.org/10.21037/atm.2017.07.08
Protti A, Andreis DT, Iapichino GE. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. New England Journal of Medicine. 2000;342(18):1301-1308.
Piraino T, Fan E. Airway pressure release ventilation in patients with acute respiratory distress syndrome: Not yet, we still need more data! Journal of Thoracic Disease. 2018;10(2):670-673.
Mauri T, Cambiaghi B, Spinelli E, Langer T, Grasselli G. Spontaneous breathing: a double-edged sword to handle with care. Annals of Translational Medicine. 2017;5(14):292. https://doi.org/10.21037/atm.2017.06.55
Mireles-Cabodevila E, Kacmarek RM. Should Airway Pressure Release Ventilation Be the Primary Mode in ARDS? Respiratory Care. 2016;61(6):761-773.
Kallet RH. Patient-ventilator interaction during acute lung injury, and the role of spontaneous breathing: part 1: respiratory muscle function during critical illness. Respiratory Care. 2011;56(2):181-189.
Lalgudi Ganesan S, Jayashree M, Chandra Singhi S, Bansal A. Airway Pressure Release Ventilation in Pediatric Acute Respiratory Distress Syndrome. A Randomized Controlled Trial. American Journal of Respiratory and Critical Care Medicine. 2018;198(9):1199-1207. https://doi.org/10.1164/rccm.201705-0989OC

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