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Motamed H.

Ahvaz Jundishapur University of Medical Sciences

Moezi M.

Ahvaz Jundishapur University of Medical Sciences

Tehrani M.D.

Ahvaz Jundishapur University of Medical Sciences

Parenteral sodium valproate and dexamethasone efficacy evaluation for alleviating migraine headache. (A randomized, controlled, double-blind study)

Authors:

Motamed H., Moezi M., Tehrani M.D.

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Journal: Russian Journal of Pain. 2024;22(2): 10‑15

DOI: 10.17116/pain20242202110

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PARENTERAL SODIUM VALPROATE AND DEXAMETHASONE EFFICACY EVALUATION FOR ALLEVIATING MIGRAINE HEADACHE. (A RANDOMIZED, CONTROLLED, DOUBLE-BLIND STUDY)
PARENTERAL SODIUM VALPROATE AND DEXAMETHASONE EFFICACY EVALUATION FOR ALLEVIATING MIGRAINE HEADACHE. (A RANDOMIZED, CONTROLLED, DOUBLE-BLIND STUDY)

To cite this article:

Motamed H, Moezi M, Tehrani MD. Parenteral sodium valproate and dexamethasone efficacy evaluation for alleviating migraine headache. (A randomized, controlled, double-blind study). Russian Journal of Pain. 2024;22(2):10‑15. (In Russ.)
https://doi.org/10.17116/pain20242202110

Подписка 2025-2 (Russian Journal of Pain)
МСФ на ЯМ
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INTRODUCTION

Treating acute migraine headaches in emergency rooms remains a challenge. This study aimed to clarify sodium valproate’s effectiveness in improving acute migraine headaches without aura in the emergency department

MATERIAL AND METHODS

Selected from emergency room patients with moderate to severe migraine (VAS ≥4), 108 individuals aged 18—60 and weighing 50—85 kg were randomly assigned to two groups: one received 1200 mg sodium valproate, and the other received 8 mg dexamethasone intravenously in 150 ml of normal saline over 10 minutes. The primary outcome compared headache scores before and 1—2 hours after intervention, as well as the percentage of patients headache-free at 2 and 24 hours post-intervention.

RESULTS

In the intervention group, headache scores reduced to 2.33±1.74 at 1 hour and 3.49±2.56 at 2 hours after intervention. In the control group, reductions were 2.20±1.86 at 1 hour and 3.30±2.45 at 2 hours. There was no statistically significant difference between the groups. Secondary outcomes showed similar percentages of patients not needing additional pain relief in both groups.

CONCLUSION

Intravenous sodium valproate (1200 mg) did not significantly differ in its effectiveness from intravenous dexamethasone (8 mg) in improving acute migraine headaches without aura.

Keywords:

sodium valproate
treatment efficacy
dexamethasone
migraine headache

Authors:

Motamed H.

Ahvaz Jundishapur University of Medical Sciences

Moezi M.

Ahvaz Jundishapur University of Medical Sciences

Tehrani M.D.

Ahvaz Jundishapur University of Medical Sciences

Received:

08.11.2023

Accepted:

16.03.2024

List of references:

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