Influence of surgical access on bacterial contamination of autologous blood in neurosurgical patients

Kvan OK, Teryaeva NB, Sukhorukova MV, Titov OYu, Lubnin AYu, Kozlov AV, Usachev DYu. Influence of surgical access on bacterial contamination of autologous blood in neurosurgical patients. Burdenko's Journal of Neurosurgery. 2025;89(5):79‑86. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20258905179

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To analyze the influence of surgical access on bacterial contamination of autologous blood and effectiveness of complex decontamination in hardware reinfusion in neurosurgery.

MATERIAL AND METHODS

The study included 107 patients with CNS tumors and high risk of intraoperative blood loss with hardware blood reinfusion. Three surgical approaches were used: transcranial, extended transcranial with opening of paranasal sinuses and transnasal endoscopic access. The protocol of perioperative antibiotic prophylaxis was used in all patients. We evaluated bacterial contamination after decontamination using microbiological testing.

RESULTS

Surgical approach significantly affected the risk of bacterial contamination of autologous blood in neurosurgical patients (p<0.001). The minimum risk was observed for transcranial approaches (29%), moderate — for extended transcranial approaches (50%), maximum — for transnasal endoscopic approaches (100%). This pattern is not presented in available literature. There were no local or systemic infectious complications in postoperative period.

CONCLUSION

Transfusion of autologous blood is quite safe in case of appropriate perioperative antibiotic prophylaxis and all measures aimed at blood decontamination. Approaches with opening the paranasal sinuses require 4-stage decontamination (cefuroxime+washing+leukofiltration+irradiation).

Keywords:

autologous blood

hardware blood reinfusion

bacterial contamination

decontamination

transcranial

extended transcranial

transnasal endoscopic surgical access

Authors:

Kvan O.K.

Burdenko Neurosurgical Center

ORCID: 0000-0002-6147-7887

Teryaeva N.B.

Burdenko Neurosurgical Center

ORCID: 0000-0001-8535-8535

Sukhorukova M.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-1168-2356

Titov O.Yu.

Burdenko Neurosurgical Center

ORCID: 0000-0001-6570-7777

Lubnin A.Yu.

Burdenko Neurosurgical Center

RSCI AuthorID: 370609
Scopus AuthorID: 57192157123
ORCID: 0000-0003-2595-5877

Kozlov A.V.

Burdenko Neurosurgical Center;
Andijan State Medical Institute

ORCID: 0000-0002-3181-6470

Usachev D.Yu.

Burdenko Neurosurgical Center;
Russian Medical Academy of Continuous Professional Education;
Botkin Hospital

ORCID: 0000-0002-9811-9442

Received:

19.06.2025

Accepted:

18.07.2025

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References:

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