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Semenov D.E.

Burdenko Neurosurgical Center

Belousova O.B.

Burdenko Neurosurgical Center

Kostyuchenko V.V.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

Radiosurgery for cerebral cavernous malformations: a systematic review

Authors:

Semenov D.E., Belousova O.B., Kostyuchenko V.V., Golanov A.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2024;88(4): 107‑116

DOI: 10.17116/neiro202488041107

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Table of contents

RADIOSURGERY FOR CEREBRAL CAVERNOUS MALFORMATIONS: A SYSTEMATIC REVIEW
RADIOSURGERY FOR CEREBRAL CAVERNOUS MALFORMATIONS: A SYSTEMATIC REVIEW

To cite this article:

Semenov DE, Belousova OB, Kostyuchenko VV, Golanov AV. Radiosurgery for cerebral cavernous malformations: a systematic review. Burdenko's Journal of Neurosurgery. 2024;88(4):107‑116. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202488041107

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Stereotactic radiosurgery (SRS) for cerebral cavernous malformations has been used for more than 30 years. However, indications for this method and outcomes are still discussable.

OBJECTIVE

To analyze available literature data on SRS for cerebral cavernous malformations with assessment of indications for treatment, radiation parameters, radiological and clinical complications and outcomes.

RESULTS

The final analysis included 20 reports describing post-SRS outcomes in 1834 patients with cerebral cavernous malformations. The main radiation parameter was mean radiation dose to the edge of cavernous malformation (prescribed dose, 13.25±2.16 Gy). In natural course of malformation, mean incidence of hemorrhages from cavernous malformation when counted after the second hemorrhage was 25.9±14.6%, after the patient’s birth — 2.59±0.44%. Mean follow-up period after SRS was 66.7±24.1 months. Incidence of hemorrhages from cavernous malformation after SRS for the first 2 years of follow-up was assessed in 14 studies (4.67±3.51%). Incidence of hemorrhages ≥2 years after SRS was analyzed in 12 studies (1.55±0.8%).

CONCLUSION

Despite significant global experience in SRS for cerebral cavernous malformations and many studies devoted to this problem, clear patient selection criteria have not yet been formulated. Modern selection principles have insufficient evidence base.

Keywords:

cavernous malformation
radiosurgery
Gamma Knife

Authors:

Semenov D.E.

Burdenko Neurosurgical Center

Belousova O.B.

Burdenko Neurosurgical Center

Kostyuchenko V.V.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

Received:

11.02.2024

Accepted:

31.05.2024

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