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Roshchina K.E.

Blokhin National Medical Research Center of Oncology

Bekyashev A.Kh.

Blokhin National Medical Research Center of Oncology;
Russian Medical Academy for Continuous Professional Education

Gasparyan T.G.

Blokhin National Medical Research Center of Oncology;
Scientific Center of Neurology

Aleshin V.A.

Blokhin National Medical Research Center of Oncology

Osinov I.K.

Burdenko Neurosurgical Center

Savateev A.N.

Burdenko Neurosurgical Center

Khalafyan D.A.

Burdenko Neurosurgical Center

Modern possibilities of neurosurgical treatment of brain metastases

Authors:

Roshchina K.E., Bekyashev A.Kh., Gasparyan T.G., Aleshin V.A., Osinov I.K., Savateev A.N., Khalafyan D.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2022;86(5): 119‑125

Read: 2888 times


To cite this article:

Roshchina KE, Bekyashev AKh, Gasparyan TG, Aleshin VA, Osinov IK, Savateev AN, Khalafyan DA. Modern possibilities of neurosurgical treatment of brain metastases. Burdenko's Journal of Neurosurgery. 2022;86(5):119‑125. (In Russ., In Engl.)
https://doi.org/10.17116/neiro202286051119

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References:

  1. Nayan L, Patrick YW, Ayal AA. Epidemiology of brain metastases and leptomeningeal disease. Neuro-Oncology. 2021;23(9):1447-1456. https://doi.org/10.1093/neuonc/noab101
  2. Banov SM, Golanov AV, Dolgushin MB, Bekyashev AKh, Vetlova ER, Durgaryan AA. Brain Metastases: Current Clinical Recommendations. Onkologicheskij zhurnal. 2018;1:75-84. (In Russ.).
  3. Banov SM, Golanov AV, Vetlova ER, Redkin AN. Radiotherapy and targeted therapy in patients with metastatic brain lesion: new treatment options. Voprosy onkologii. 2017;63:684-694. (In Russ.).
  4. Eichler AF, Loeffler JS. Multidisciplinary management of brain metastases. The Oncologist. 2007;12:884-898.  https://doi.org/10.1634/theoncologist.12-7-884
  5. Thomas SS, Dunbar EM. Modern multidisciplinary management of brain metastases. Current Oncology Reports. 2010;12:3440. https://doi.org/10.1007/s11912-009-0073-8
  6. Ranasinghe MG, Sheehan JM. Surgical management of brain metastases. Neurosurgical Focus. 2007;22(3):E2.  https://doi.org/10.3171/foc.2007.22.3.3
  7. Vogelbaum MA, Angelov L, Lee S-Y, Li L, Barnett GH, Suh JH. Local control of brain metastases by stereotactic radiosurgery in relation to dose to the tumor margin. Journal of Neurosurgery. 2006;104(6):907-912.  https://doi.org/10.3171/jns.2006.104.6.907
  8. Nahed BV, Elder JB, Linskey ME, Olson JJ. Congress of neurological surgeons systematic review and evidence-based guidelines on the role of surgery in the management of adults with metastatic brain tumors. Neurosurgery. 2019;84(3):201-203.  https://doi.org/10.1093/neuros/nyy547
  9. Ferguson SD, Wagner KM, Prabhu SS, McAleer MF, McCutcheon IE, Sawaya R. Neurosurgical management of brain metastases. Clinical and Experimental Metastasis. 2017;34(6-7):377-389.  https://doi.org/10.1007/s10585-017-9860-z
  10. Narita Y, Shibui S. Strategy of surgery and radiation therapy for brain metastases. International Journal of Clinical Oncology. 2009;14(4):275-280.  https://doi.org/10.1007/s10147-009-0917-0
  11. Sandberg DI, Bilsky MH, Souweidane MM, Bzdil J, Gutin PH. Ommaya reservoirs for the treatment of leptomeningeal metastases. Neurosurgery. 2000;47(1):49-54, discussion 45-55.  https://doi.org/10.1097/00006123-200007000-00011
  12. Yoshida S, Takahashi H. Cerebellar metastases in patients with cancer. Surgical Neurology. 2009;71(2):184-187; discussion 187.  https://doi.org/10.1016/j.surneu.2007.10.010
  13. Shah AH, Mahavadi AK, Morell A, Eichberg DG, Luther E, Sarkiss CA. Salvage craniotomy for treatment-refractory symptomatic cerebral radiation necrosis. Neuro-Oncology Practice. 2020;7(1):94-102.  https://doi.org/10.1093/nop/npz028
  14. Gaspar L, Scott C, Rotman M. Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials. Clinical Investigation. 1997;37(4):745-751.  https://doi.org/10.1016/S0360-3016(96)00619-0
  15. Agboola O, Benoit B, Cross P. Prognostic factors derived from recursive partition analysis (RPA) of Radiation Therapy Oncology Group (RTOG) brain metastases trials applied to surgically resected and irradiated brain metastatic cases. International Journal of Radiation Oncology. Biology. Physics. 1998;42(1):155-159.  https://doi.org/10.1016/s0360-3016(98)00198-9
  16. Sperduto PW, Kased N, Roberge D, Xu Z, Shanley R, Luo X. Summary report on the graded prognostic assessment: an accurate and facile diagnosis-specific tool to estimate survival for patients with brain metastases. Journal of Clinical Oncology. 2012;30(4):419-425.  https://doi.org/10.1200/JCO.2011.38.0527
  17. Narita Y, Shibui S. Strategy of surgery and radiation therapy for brain metastases. International Journal of Clinical Oncology. 2009;14:275-280. 
  18. Schiff D. Single brain metastasis. Current Treatment Options in Neurology. 2001;3(1):89-99.  https://doi.org/10.1007/s11940-001-0027-4
  19. Gavrilovic IT, Posner JB. Brain metastases: epidemiology and pathophysiology. Journal of Neuro-Oncology. 2005;75(1):5-14.  https://doi.org/10.1007/s11060-004-8093-6
  20. Obermueller T, Schaeffner M, Gerhardt J. Risks of postoperative paresis in motor eloquently and noneloquently located brain metastases. BMC Cancer. 2014;14(1):21.  https://doi.org/10.1186/1471-2407-14-21
  21. Berghoff AS, Rajky O, Winkler F. Invasion patterns in brain metastases of solid cancers. Neuro-Oncology. 2013;15(12):1664-1672. https://doi.org/10.1093/neuonc/not112
  22. Yoo H, Kim YZ, Nam BH. Reduced local recurrence of a single brain metastasis through microscopic total resection. Journal of Neurosurgery. 2009;110(4):730-736.  https://doi.org/10.3171/2008.8.JNS08448
  23. Kamp MA, Rapp M, Slotty PJ. Incidence of local in-brain progression after supramarginal resection of cerebral metastases. Acta Neurochirurgica. 2015;157(6):905-910; discussion 910-911.  https://doi.org/10.1007/s00701-015-2405-9
  24. Lee CH, Kim DG, Kim JW. The role of surgical resection in the management of brain metastasis: A 17-year longitudinal study. Acta Neurochirurgica. 2013;155(3):389-397.  https://doi.org/10.1007/s00701-013-1619-y
  25. Patel AJ, Suki D, Hatiboglu MA. Impact of surgical methodology on the complication rate and functional outcome of patients with a single brain metastasis. Journal of Neurosurgery. 2015;122(5):1132-1143. https://doi.org/10.3171/2014.9.JNS13939
  26. Van der Ree TC, Dippel DW, Avezaat CJ. Leptomeningeal metastasis after surgical resection of brain metastases. Journal of Neurology, Neurosurgery, and Psychiatry. 1999;66(2):225-227.  https://doi.org/10.1136/jnnp.66.2.225
  27. Suki D, Abouassi H, Patel AJ. Comparative risk of leptomeningeal disease after resection or stereotactic radiosurgery for solid tumor metastasis to the posterior fossa. Journal of Neurosurgery. 2008;108(2):248-257.  https://doi.org/10.3171/JNS/2008/108/2/0248
  28. Ruge MI, Suchorska B, Maarouf M. Stereotactic 125-iodine brachytherapy for the treatment of singular brain metastases: closing a gap? Neurosurgery. 2013;15(12):1721-1731. https://doi.org/10.1093/neuonc/not126
  29. Vogelbaum MA, Suh JH. Resectable brain metastases. International Journal of Clinical Oncology. 2006;24(8):1289-1294. https://doi.org/10.1200/JCO.2005.04.6235
  30. Krings T, Buchbinder BR, Butler WE. Functional magnetic resonance imaging and transcranial magnetic stimulation: complementary approaches in the evaluation of cortical motor function. Neurology. 1997;48(5):1406-1416. First published May 01, 1997. https://doi.org/10.1212/wnl.48.5.1406
  31. Rutten GJ, Ramsey NF. The role of functional magnetic resonance imaging in brain surgery. Neurosurgery. 2010;8(2):E4.  https://doi.org/10.3171/2009.12.FOCUS09251
  32. Krieg SM, Shiban E, Buchmann N. Utility of presurgical navigated transcranial magnetic brain stimulation for the resection of tumors in eloquent motor areas. Journal of Neurosurgery. 2012;116(5):994-1001. https://doi.org/10.3171/2011.12.JNS111524
  33. Krieg SM, Picht T, Sollmann N. Resection of motor eloquent metastases aided by preoperative nTMS-based motor maps — comparison of two observational cohorts. Frontiers in Oncology. 2016;6:261.  https://doi.org/10.3389/fonc.2016.00261
  34. Romagna A, Unterrainer M, Schmid-Tannwald C. Suspected recurrence of brain metastases after focused high dose radiotherapy: can [18F]FET-PET overcome diagnostic uncertainties? Radiation Oncology. 2016;11(1):139.  https://doi.org/10.1186/s13014-016-0713-8
  35. Kombos T, Suess O, Funk T. Intra-operative mapping of the motor cortex during surgery in and around the motor cortex. Acta Neurochirurgica. 2000;142(3):263-268.  https://doi.org/10.1007/s007010050034
  36. Neuloh G, Pechstein U, Schramm J. Motor tract monitoring during insular glioma surgery. Journal of Neurosurgery. 2007;106(4):582-592.  https://doi.org/10.3171/jns.2007.106.4.582
  37. Sanai N, Berger MS. Mapping the horizon: techniques to optimize tumor resection before and during surgery. Clinical Neurosurgery. 2008;55:14-19. 
  38. Schackert G, Schmiedel K, Lindner C, Leimert M, Kirsch M. Surgery of recurrent brain metastases: retrospective analysis of 67 patients. Acta Neurochirurgica. 2013;155(10):1823-1832. https://doi.org/10.1007/s00701-013-1821-y
  39. Hatiboglu MA, Wildrick DM, Sawaya R. The role of surgical resection in patients with brain metastases. Ecancermedicalscience. 2013;7:308.  https://doi.org/10.3332/ecancer.2013.308
  40. Paek SH, Audu PB, Sperling MR, Cho J, Andrews DW. Reevaluation of surgery for the treatment of brain metastases: review of 208 patients with single or multiple brain metastases treated at one institution with modern neurosurgical techniques. Neurosurgery. 2005;56(5):1021-1034; discussion 1021-1034.
  41. Bindal RK, Sawaya R, Leavens ME, Lee JJ. Surgical treatment of multiple brain metastases. Journal of Neurosurgery. 1993;79(2):210-216.  https://doi.org/10.3171/jns.1993.79.2.0210
  42. Stark AM, Tscheslog H, Buhl R, Held-Feindt J, Mehdorn HM. Surgical treatment for brain metastases: prognostic factors and survival in 177 patients. Neurosurgical Review. 2005;28(2):115-119.  https://doi.org/10.1007/s10143-004-0364-3
  43. Wronski M, Arbit E, McCormick B. Surgical treatment of 70 patients with brain metastases from breast carcinoma. Cancer. 1997;80(9):1746-1754. https://doi.org/10.1002/(sici)1097-0142(19971101)80:9<1746::aid-cncr 8>3.0.co;2-c
  44. Bindal RK, Sawaya R, Leavens ME, Hess KR, Taylor SH. Reoperation for recurrent metastatic brain tumors. Journal of Neurosurgery. 1995;83(4): 600-604.  https://doi.org/10.3171/jns.1995.83.4.0600
  45. Naskhletashvili DR, Absalyamova OV, Aleshin VA, Banov SM, Bekyashev AKh, Belov DM, et al. Practical recommendations for drug treatment of metastatic brain tumors. Zlokachestvennye opukholi. 2015;4(Special Issue):80-98.  https://doi.org/10.18027/2224-5057-2015-4s-80-98
  46. Truong M, St Clair E, Donahue B, Rush S, Miller D, Formenti S, Knopp E, Han K, Golfinos J. Results of surgical resection for progression of brain metastases previously treated by gamma knife radiosurgery. Journal of Neurosurgery. 2006;59(1):86-97; discussion 86-97.  https://doi.org/10.1227/01.NEU.0000219858.80351.38
  47. Luther N, Kondziolka D, Kano H, Mousavi SH, Engh JA, Niranjan A, Flickinger JC, Lunsford LD. Predicting tumor control after resection bed radiosurgery of brain metastases. Neurosurgery. 2013;73(6):1001-1006. https://doi.org/10.1227/NEU.0000000000000148
  48. Vecil GG, Suki D, Maldaun MV, Lang FF, Sawaya R. Resection of brain metastases previously treated with stereotactic radiosurgery. Journal of Neurosurgery. 2005;102(2):209-215.  https://doi.org/10.3171/jns.2005.102.2.0209

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