Hypofractionated stereotactic irradiation for optic nerve glioma

Zagirov R.I.; Trunin Yu.Yu.; Serova N.K.; Pronin I.N.; Antipina N.A.; Golanov A.V.

doi:https://doi.org/10.17116/neiro20228605174

Zagirov R.I.

Burdenko Neurosurgical Center

Trunin Yu.Yu.

Burdenko Neurosurgical Center

Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Pronin I.N.

Burdenko Neurosurgical Center

SPIN RSCI: 9223-9217
Scopus AuthorID: 7006011755
ORCID: 0000-0002-4480-0275

Antipina N.A.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-0976-4547

Hypofractionated stereotactic irradiation for optic nerve glioma

Authors:

Zagirov R.I., Trunin Yu.Yu., Serova N.K., Pronin I.N., Antipina N.A., Golanov A.V.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2022;86(5): 74‑80

DOI: 10.17116/neiro20228605174

Read: 4493 times

To cite this article:

Zagirov RI, Trunin YuYu, Serova NK, Pronin IN, Antipina NA, Golanov AV. Hypofractionated stereotactic irradiation for optic nerve glioma. Burdenko's Journal of Neurosurgery. 2022;86(5):74‑80. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20228605174

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

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Abstract:

Optic nerve glioma is a rather rare tumor. It predominantly arises in pediatric patients, including those with type I neurofibromatosis. This neoplasm is accompanied by decreased visual function and exophthalmos. Treatment strategy is individualized depending on age, volume and spread of tumor, as well as severity of clinical manifestations. Possible treatment options are surgical resection, chemotherapy, radiotherapy and their combination. Radiotherapy can be recommended for patients with intact visual functions, no severe proptosis and trophic lesions. Classic fractionation mode is used as a standard. Currently, the possibility of hypofractionated irradiation is being considered.

OBJECTIVE

To evaluate safety and efficacy of hypofractionated radiotherapy in patients with optic nerve glioma.

MATERIAL AND METHODS

Sixteen patients with optic nerve gliomas underwent hypofractionated stereotactic irradiation (CyberKnife) between May 2014 and October 2019. Single focal dose was 5.5 Gy. There were 5 fractions up to total focal dose of 27.5 Gy. The sample enrolled 14 children with a median age of 4 years (range 23 months — 13 years) and 2 adults aged 47 and 66 years, respectively. Median of tumor volume was 2.77 cm³ (range 1.69-10.01 cm³).

RESULTS

Tumor growth control was achieved in all patients, partial remission was observed in 5 (32%) patients. None patient had deterioration of visual function. Improvement of visual acuity was noted in 3 (19%) cases. Visual field enlargement occurred in 4 (67%) out of 6 patients who were preoperatively examined. After irradiation, proptosis decreased by ≥ 1 mm in 9 (60%) out of 15 patients.

Keywords:

optic nerve glioma

stereotactic irradiation

hypofractionated mode

multisession radiosurgery

pilocytic astrocytoma

type I neurofibromatosis

Authors:

Zagirov R.I.

Burdenko Neurosurgical Center

Trunin Yu.Yu.

Burdenko Neurosurgical Center

Serova N.K.

N.N. Burdenko National Medical Research Center of Neurosurgery

Pronin I.N.

Burdenko Neurosurgical Center

SPIN RSCI: 9223-9217
Scopus AuthorID: 7006011755
ORCID: 0000-0002-4480-0275

Antipina N.A.

Burdenko Neurosurgical Center

Golanov A.V.

Burdenko Neurosurgical Center

ORCID: 0000-0002-0976-4547

Received:

20.07.2022

Accepted:

19.08.2022

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