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Khachatryan R.G.

Almazov National Medical Research Center

Bart V.A.

Almazov National Medical Research Center;
Saint-Petersburg State University

Maslova L.N.

Almazov National Medical Research Center

Fadeeva T.N.

Almazov National Medical Research Center

Sebelev K.I.

Almazov National Medical Research Center

Tastanbekov M.M.

Almazov National Medical Research Center

Alekseeva T.M.

I.M. Sechenov First Moscow State Medical University

Khachatryan V.A.

Almazov National Medical Research Center

Clinical, structural and functional features of paroxismal syndrome in insular and temporal lobe tumors

Authors:

Khachatryan R.G., Bart V.A., Maslova L.N., Fadeeva T.N., Sebelev K.I., Tastanbekov M.M., Alekseeva T.M., Khachatryan V.A.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2020;84(4): 36‑45

DOI: 10.17116/neiro20208404136

Read: 4319 times

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Table of contents

CLINICAL, STRUCTURAL AND FUNCTIONAL FEATURES OF PAROXISMAL SYNDROME IN INSULAR AND TEMPORAL LOBE TUMORS
CLINICAL, STRUCTURAL AND FUNCTIONAL FEATURES OF PAROXISMAL SYNDROME IN INSULAR AND TEMPORAL LOBE TUMORS

To cite this article:

Khachatryan RG, Bart VA, Maslova LN, et al. . Clinical, structural and functional features of paroxismal syndrome in insular and temporal lobe tumors. Burdenko's Journal of Neurosurgery. 2020;84(4):36‑45. (In Russ., In Engl.)
https://doi.org/10.17116/neiro20208404136

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To analyze the characteristics of paroxysmal syndrome in insular and temporal lobe tumors, to determine their relationship with the histological structure of tumor, to assess the effect of tumor growth nature on severity of disease.

MATERIAL AND METHODS

A retrospective analysis enrolled 80 patients aged 11 — 80 years with insular and temporal lobe tumors and symptomatic epilepsy. All patients underwent surgery at the Polenov National Research Neurosurgery Center in Almazov National Medical Research Center for the period from 2012 to 2018.

RESULTS

The main group consisted of 29 patients with tumors of temporal and insular lobes. Control group of 51 patients with temporal gliomas was formed for comparative analysis. It was found that involvement of insular lobe into paroxysmal syndrome is characterized by attacks with a motor component, somatosensory paroxysms, vegetative manifestations (respiratory attacks, salivation, nausea), speech disorders and taste hallucinations. Derealization, motor arrest and déjà vu/jamis vu paroxysms were more common in patients with temporal lobe lesion. Neoplastic lesion of the insular lobe shortens the period between manifestation of paroxysms and surgical treatment. Moreover, this type of disease is characterized by higher incidence of seizures compared to isolated temporal lobe tumors.

Keywords:

insular epilepsy
temporal lobe epilepsy
insular glioma
epilepsy surgery

Authors:

Khachatryan R.G.

Almazov National Medical Research Center

Bart V.A.

Almazov National Medical Research Center;
Saint-Petersburg State University

Maslova L.N.

Almazov National Medical Research Center

Fadeeva T.N.

Almazov National Medical Research Center

Sebelev K.I.

Almazov National Medical Research Center

Tastanbekov M.M.

Almazov National Medical Research Center

Alekseeva T.M.

I.M. Sechenov First Moscow State Medical University

Khachatryan V.A.

Almazov National Medical Research Center

Received:

16.01.2020

Accepted:

24.04.2020

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References:

  1. Maschio M. Brain tumor related epilepsy. Current Neuropharmacology. 2012;10(2):124-133.  https://doi.org/10.2174/157015912800604470
  2. Duffau H. A personal consecutive series of surgically treated 51 cases of insular WHO Grade II glioma: advances and limitations. Journal of Neurosurgery. 2009;110(4):696-708.  https://doi.org/10.3171/2008.8.JNS08741
  3. Zentner J, Meyer B, Stangl A, Schramm J. Instinsic tumors of the insula:a prospective surgical study of 30 patients. Journal of Neurosurgery. 1996;83:263-271.  https://doi.org/10.3171/jns.1996.85.2.0263
  4. Praveen K, Manish A, Deo SV, Anu B. Epidemiological study of insular glioma — an institutional experience. Romanian Neurosurgery. 2017;31(1):90-96.  https://doi.org/10.1515/romneu-2017-0014
  5. Duffau H, Tallandeir L, Gatignol P, Capelle L. The insular lobe and brain plasticity: Lessons from tumor surgery. Clinical Neurology and Neurosurgery. 2005;108:543-548.  https://doi.org/10.1016/j.clineuro.2005.09.004
  6. Ius T, Pauletto G, Isola M, Gregoraci G, Budai R, Lettieri C, Paulett G, Eleopra R, Fadig L, Skrap M. Surgery for insular low-grade glioma: predictors of postoperative seizure outcome. Journal of Neurosurgery. 2014;120(1):12-23.  https://doi.org/10.3171/2013.9.jns13728
  7. Isnard J, Guenot M, Ostrowsky K, Sindou M, Maugiere F. The role of the insular cortex in the temporal lobe epilepsy. Annals of Neurology. 2000;48(4):614-623. https://doi.org/10.1002/1531-8249(200010)48:4<614::AID-ANA8>3.0.CO;2-S "> 3.0.CO;2-S" target="_blank">https://doi.org/10.1002/1531-8249(200010)48:4<614::AID-ANA8>3.0.CO;2-S
  8. Chevrier MC, Bard C, Guilbert F, Nguyen DK. Structural Abnormalities in Patients with Insular/Peri-insular Epilepsy: Spectrum, Frequency, and Pharmacoresistance. American Journal of Neuroradiology. 2013;34(11):2152-2156. https://doi.org/10.3174/ajnr. A3636
  9. Khachatryan RG, Ibatova GS, Alekseyeva TM, Khachatryan WA. Diagnostic evaluation of drug-resistant insular epilepsy. Epilepsiya i paroksizmal’nye sostoyaniya. 2018;10(4):83-92. (In Russ.). https://doi.org/10.17749/2077-8333.2018.10.4.083-092
  10. Surbeck W, Bouthillier A, Nguyen DKh. Refractory insular cortex epilepsy: clinical features, investigation and treatment. Future Neurology. 2010;5:498-507.  https://doi.org/10.2217/fnl.10.36
  11. Wang DD, Deng H, Hervey-Jumper SL, Molinaro AA, Chang EF, Berger MS. Seizure Outcome after Surgical Resection of Insular Glioma. Neurosurgery. 2018;83(4):709-718.  https://doi.org/10.1093/neuros/nyx486
  12. Fisher RS, Cross JH, French JA, Higurashi N, Hirsch E, Jansen FE, Lagae L, Moshe SL, Peltola J, Perez ER, Scheffer IE, Zuberi SM. Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58(4):522-530.  https://doi.org/10.1111/epi.13670
  13. Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathologica. 2016;131(6):803-820.  https://doi.org/10.1007/s00401-016-1545-1
  14. Oppenheimer SM, Gelb A, Girvin JP, Hachinski VC. Cardiovascular effects of human insular cortex stimulation. Neurology. 1992;42(9):1727-1732. https://doi.org/10.1212/wnl.42.9.1727
  15. Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Research Reviews. 1996;22:229-244.  https://doi.org/10.1016/s0165-0173(96)00011-2
  16. Barba C, Minotti L, Job AS, Kahane P. The insula in temporal plus epilepsy. Journal of Clinical Neurophysiology. 2017;34(4):324-327.  https://doi.org/10.1097/WNP.0000000000000389
  17. Kissin MYa, Alekseeva TM, Khachatryan RG. Prognostic value of involvement insular lobe in epileptic process in temporal lobe epilepsy. Rossijskij nejrohirurgicheskij zhurnal im. prof. A.L. Polenova. 2018;10:117. (In Russ.).
  18. Insard J, Guenot M, Mauguire F. Clinical manifestations of insular lobe seizures: a stereo-electroencephalographic study. Epilepsia. 2004;45:1079-1090. https://doi.org/10.1111/j.0013-9580.2004.68903.x
  19. Ostrowsky K, Isnard J, Ryvelin Ph, Guenot M, Fischer C, Mauguiere F. Functional mapping of the insular cortex: clinical implication in temporal lobe epilepsy. Epilepsia. 2000;41(6):681-686.  https://doi.org/10.1111/j.1528-1157.2000.tb00228.x
  20. Khachatryan RG, Odintsova GV, Don OA, Kim AV, Telegina AA, Ivanov AYu, Ivanova NE, Khachatryan VA. Ethology of insular epilepsy. Clinical manifestations and management tactics for cerebral cavernous angiomas. Kazanskij medicinskij zhurnal. 2018;99(1):151-157. (In Russ.). https://doi.org/10.17816/KMJ2018-151
  21. Nguyen DK, Nguyen DB, Malak R, Bouthillier A. Revisiting the role of the insula in refractor partial epilepsy. Epilepsia. 2009;50(3):510-520.  https://doi.org/10.1111/j.1528-1167.2008.01758.x
  22. Blauwbomme T, David O, Minotti L, Job AS. Prognostic value of insular lobe involvement in temporal lobe epilepsy: A stereoelectroencephalographic study. Epilepsia. 2013;54(9):1658-1667. https://doi.org/10.1111/epi.12260
  23. Afif A, Minotti L, Kahane P, Hoffman D. Anatomofunctional organization of insular cortex: a study using intracerebral electrical stimulation in epileptic parents. Epilepsia. 2010;51(11):2305-2310. https://doi.org/10.1111/j.1528-1167.2010.02755.x
  24. Dionisio S, Koenig A, Murray J, Somerville E. A gut feeling about insular seizures. BMJ Case Reports.2011:bcr1220103647. https://doi.org/10.1136/bcr.12.2010.3647
  25. Catenoix H, Isnard J, Guenot M, Petit J, Remy C, Mauguiere F. The role of the anterior insular cortex in ictal vomiting: A stereotactic encephalography study. Epilepsy and Behavior. 2008;13(3):560-563.  https://doi.org/10.1016/j.yebeh.2008.06.019
  26. Fukuda H, Yamada K, Kinomura S, Kawishima R, Cuo S. High order gustatory projections in the human brain studied with positron emission tomography. The salt sciens annual research report. Journal of Food Science. 1991;69(4):337-347.  https://doi.org/10.1111/j.1365-2621.2004.tb06357.x
  27. Buklina SB, Bykanov AE, Pitskhelauri DI. Clinical characteristics of epileptic seizures in insular gliomas. Zhurnal nevrologii i psihiatrii im. S.S. Korsakova. 2016;116(12):13-19. (In Russ.). https://doi.org/10.17116/jnevro201611612113-19
  28. Stephani C, Fernandez-Baca Vaca G, Maciunas R, Koubeissi M, Luders HO. Functional neuroanatomy of the insular lobe. Brain Structure and Function. 2011;216(2):137-149.  https://doi.org/10.1007/s00429-010-0296-3
  29. Donkers NF. A new brain region for coordinating speech articulation. Nature. 1996;384(6605):159-161.  https://doi.org/10.1038/384159a0
  30. Ryvlin P, Minotti L, Demarquay G, Hirsch E, Arzimanoglou A, Hoffman D, Guénot M, Picard F, Rheims S, Kahane P. Noctunal hypermotor seizures, suggesting frontal lobe epilepsy can originate in the insula. Epilepsia. 2006;47:755-765.  https://doi.org/10.1111/j.1528-1167.2006.00510.x
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