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Baranich A.I.

Burdenko Neurosurgery Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

Savin I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Tabasaranskiĭ T.F.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Polupan A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Sychev A.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kurdyumova N.V.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Pilipenko Iu.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Mikeladze K.G.

Burdenko’ National medical research center of neurosurgery, Moscow, Russia

Éliava Sh.Sh.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Disturbances of the hemostatic system in patients with aneurysmal subarachnoid hemorrhage

Authors:

Baranich A.I., Savin I.A., Tabasaranskiĭ T.F., Polupan A.A., Sychev A.A., Kurdyumova N.V., Pilipenko Iu.V., Mikeladze K.G., Éliava Sh.Sh.

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Journal: Burdenko's Journal of Neurosurgery. 2018;82(4): 109‑116

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Table of contents

DISTURBANCES OF THE HEMOSTATIC SYSTEM IN PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE
DISTURBANCES OF THE HEMOSTATIC SYSTEM IN PATIENTS WITH ANEURYSMAL SUBARACHNOID HEMORRHAGE

To cite this article:

Baranich AI, Savin IA, Tabasaranskiĭ TF, et al. . Disturbances of the hemostatic system in patients with aneurysmal subarachnoid hemorrhage. Burdenko's Journal of Neurosurgery. 2018;82(4):109‑116. (In Russ., In Engl.)

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)
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Abstract:

Subarachnoid hemorrhages due to rupture of cerebral aneurysms are characterized by high mortality. More than 25% of patients who have survived the first hours after aneurysmal SAH (aSAH) develop delayed cerebral ischemia that is one of the main causes of disability. The mechanisms underlying delayed ischemia have not yet been fully understood. Previously, the development of vasospasm was believed to be the only cause for development of delayed ischemia. In recent years, there has been evidence that hemostatic system disorders typical of this category of patients are the cause of cerebral artery thrombosis, which is one of the main pathophysiological mechanisms for the development of delayed cerebral ischemia. This review presents an analysis of published papers on hemostasis disturbances in patients with aSAH, their pathophysiological mechanisms, and their role in the development of cerebral ischemia.

Keywords:

neurosurgical patients
subarachnoid hemorrhage
aSAH
hemostasis disturbances
microthrombosis
platelet activation
delayed cerebral ischemia
hypercoagulation
tissue factor
secondary brain injury

Authors:

Baranich A.I.

Burdenko Neurosurgery Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047

Savin I.A.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Tabasaranskiĭ T.F.

FGBU "NII neĭrokhirurgii im. N.N. Burdenko" RAMN, Moskva

Polupan A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Sychev A.A.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Kurdyumova N.V.

Federal State Autonomous Institution «N.N. Burdenko National Medical Research Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia, 125047, Moscow, 4-th Tverskaya-Yamskaya str.,16, Russia

Pilipenko Iu.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva

Mikeladze K.G.

Burdenko’ National medical research center of neurosurgery, Moscow, Russia

Éliava Sh.Sh.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

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