The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.
Shelesko E.V.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
Kravchuk A.D.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Kapitanov D.N.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Chernikova N.A.
Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047
Zinkevich D.N.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
A modern approach to the diagnosis of nasal liquorrhea
Journal: Burdenko's Journal of Neurosurgery. 2018;82(3): 103‑111
Read: 33519 times
To cite this article:
Shelesko EV, Kravchuk AD, Kapitanov DN, Chernikova NA, Zinkevich DN. A modern approach to the diagnosis of nasal liquorrhea. Burdenko's Journal of Neurosurgery.
2018;82(3):103‑111. (In Russ., In Engl.)
https://doi.org/10.17116/neiro2018823103
Nasal liquorrhea is cerebrospinal fluid leakage from cerebrospinal fluid spaces of the cerebral cavity into the nasal cavity or paranasal sinuses due to congenital or acquired abnormalities of the skull base bones and meninges of various etiologies. The severity of liquorrhea varies from hidden manifestations to profuse leakage of cerebrospinal fluid from the nasal cavity. The diagnosis of overt nasal liquorrhea is not problematic, but the diagnosis of latent liquorrhea is a challenge. In this case, the disease leads to potentially fatal complications, such as meningitis (the risk amounts to 10―37%), pneumocephaly, pneumonia, etc. These peculiarites give rise to two main tasks: early diagnosis confirming liquorrhea and accurate identification of the CSF fistula location when planning further surgical management. Purpose — the study purpose was to review and comparatively analyze all modern methods of diagnosing nasal liquorrhea as well as to substantiate the most effective and promising approaches and algorithms. Material and methods. The study included papers in English and Russian found in the Pubmed database and related to the diagnosis of basal liquorrhea of different etiology and localization. Results. This review demonstrates that diagnostic tests vary widely in sensitivity, specificity, accuracy, invasiveness, and cost. Given all the criteria, detection of beta-2 transferrin or beta-trace protein is the best method for confirming nasal liquorrhea, and high-resolution computed tomography is the best technique for localization of the abnormality. Conclusion. Based on the review, we suggest a diagnostic algorithm for nasal liquorrhea. However, the evidence presented in this review is unfortunately not very reliable, which indicates the existing need for more accurate studies.
Keywords:
Authors:
Shelesko E.V.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
Kravchuk A.D.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Kapitanov D.N.
NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva
Chernikova N.A.
Burdenko Neurosurgical Institute, 4-ya Tverskaya-Yamskaya Str., 16, Moscow, Russia, 125047
Zinkevich D.N.
FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN, Moskva
List of references:
Close metadata
Email Confirmation
An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.
Email Confirmation
Log in to the site using your account in one of the services
We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.