Intraoperative combined spectroscopy (optical biopsy) of cerebral gliomas

Potapov A.A.; Goriaĭnov S.A.; Loshchenov V.B.; Savel'eva T.A.; Gavrilov A.G.; Okhlopkov V.A.; Zhukov V.Iu.; Zelenkov P.V.; Gol'bin D.A.; Shurkhaĭ V.A.; Shishkina L.V.; Grachev P.V.; Kholodtsova M.N.; Kuz'min S.G.; Vorozhtsov G.N.; Chumakova A.P.

doi:https://doi.org/

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Loshchenov V.B.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Savel'eva T.A.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Gavrilov A.G.

N.N. Burdenko Institute of Neurosurgery, Moscow, Russia

Okhlopkov V.A.

GBOU "Omskaia gosudarstvennaia meditsinskaia akademiia" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii

Zhukov V.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Zelenkov P.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Gol'bin D.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shurkhaĭ V.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Grachev P.V.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kholodtsova M.N.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kuz'min S.G.

Research Institute of Clinical Oncology at N.N. Blokhin Oncological Research Centre

Vorozhtsov G.N.

'Intermedbiofizkhim' International Research and Clinical Centre, Moscow

Chumakova A.P.

Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova, Moskva

Intraoperative combined spectroscopy (optical biopsy) of cerebral gliomas

Authors:

Potapov A.A., Goriaĭnov S.A., Loshchenov V.B., Savel'eva T.A., Gavrilov A.G., Okhlopkov V.A., Zhukov V.Iu., Zelenkov P.V., Gol'bin D.A., Shurkhaĭ V.A., Shishkina L.V., Grachev P.V., Kholodtsova M.N., Kuz'min S.G., Vorozhtsov G.N., Chumakova A.P.

More about the authors

Journal: Burdenko's Journal of Neurosurgery. 2013;77(2): 3‑10

Read: 1338 times

To cite this article:

Potapov AA, Goriaĭnov SA, Loshchenov VB, et al. . Intraoperative combined spectroscopy (optical biopsy) of cerebral gliomas. Burdenko's Journal of Neurosurgery. 2013;77(2):3‑10. (In Russ., In Engl.)

Подписка 2025 Журнал «Вопросы нейрохирургии» имени Н.Н. Бурденко (Burdenko's Journal of Neurosurgery)

Использование инфографики авторами научных работ

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Abstract:

Clinical studies have revealed high selectivity of 5-ALA-induced protoporphyrin IX accumulation in different brain tumors. Modern methods of evaluation of tissues visible fluorescence are based on the qualitative analysis of the images. Up-to-date methods of combined spectral analysis allow fulfilling the intraoperative quantitative evaluation of the protoporphyrin IX content, as well as the scattering and absorption properties of a tissue. This paper presents a new method of the simultaneous analysis of hemoglobin concentration in oxygenated and reduced forms, tumor marker concentration (5-ALA-induced PP IX) and a new way to analyze the changes in the scattering properties of the tissues. The method is implemented by splitting the visible spectrum into intervals where hemoglobin and protoporphyrin IX have the characteristic peaks of absorption and fluorescence. The present method shows the dependence of the fluorescence index from the tumor grade. Combined spectroscopy (optical biopsy) can detect the differences between the subtypes of gliomas that are similar in the protoporphyrin IX fluorescence index. This method complements and enhances the diagnostic capabilities of spectroscopy, which is particularly important in the non-fluorescent glioma surgery.

Keywords:

glioma

5-АLA

fluorescence-based diagnostics

combined spectroscopy

Authors:

Potapov A.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Goriaĭnov S.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Loshchenov V.B.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Savel'eva T.A.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Gavrilov A.G.

N.N. Burdenko Institute of Neurosurgery, Moscow, Russia

Okhlopkov V.A.

GBOU "Omskaia gosudarstvennaia meditsinskaia akademiia" Ministerstva zdravookhraneniia Rossiĭskoĭ Federatsii

Zhukov V.Iu.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Zelenkov P.V.

FGBU "NII neĭrokhirurgii im. akad. N.N. Burdenko" RAMN

Gol'bin D.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shurkhaĭ V.A.

NII neĭrokhirurgii im. akad. N.N. Burdenko RAMN, Moskva

Shishkina L.V.

Burdenko Neurosurgery Institute, Moscow, Russia

ORCID: 0000-0001-7045-7223

Grachev P.V.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kholodtsova M.N.

Institut obshcheĭ fiziki im. A.M. Prokhorova RAN

Kuz'min S.G.

Research Institute of Clinical Oncology at N.N. Blokhin Oncological Research Centre

Vorozhtsov G.N.

'Intermedbiofizkhim' International Research and Clinical Centre, Moscow

Chumakova A.P.

Fakul'tet fundamental'noĭ meditsiny MGU im. M.V. Lomonosova, Moskva

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References:

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