Proinflammatory activity of monocytes and activity of glutathione-dependent enzymes in red blood cells in women with depressive conditions

Vasilyeva EF, Savushkina OK, Prokhorova TA, Tereshkina EB, Boksha IS, Sizov SV, Oleichik IV. Proinflammatory activity of monocytes and activity of glutathione-dependent enzymes in red blood cells in women with depressive conditions. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(6):120‑125. (In Russ.)
https://doi.org/10.17116/jnevro2024124061120

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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OBJECTIVE

To search for possible connections between the anti-inflammatory activity of monocytes (PAM) and the activity of glutathione metabolic enzymes: glutathione reductase (GR) and glutathione-S-transferase (GT) in patients with depressive states (DS) within various mental pathologies, as well as between the studied biological parameters and clinical condition of patients.

MATERIAL AND METHODS

Sixty-one women, aged 18—56 years, with DC were examined before and after treatment. Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS) and the Hamilton Depressive Symptom Rating Scale (HDRS-21). The control group included 23 women of the corresponding age without mental pathology. Biological parameters were assessed in the peripheral blood of patients and healthy people.

RESULTS

Patients with a high level of PAM compared to the control (p<0.001) (subgroup 1, n=31) and with a low (at the control level) level (subgroup 2, n=30) were identified. In the subgroup 1, the values of GR and GT were significantly lower than in patients of subgroup 2 (p<0.05 and p<0.01, respectively). Negative correlations between the level of PAM before treatment and GR before and after treatment were revealed in patients who responded to treatment (r=–0.67; p=0.0041; r=–0.76; p=0.0001).

CONCLUSION

The results may indicate the inverse relationship between the level of PAM and the activity of GR and GT, which are involved in the pathogenesis of DC, and can also serve as criteria for assessing the response of patients to treatment.

Keywords:

depressive conditions

proinflammatory activity of monocytes

erythrocytes

glutathione reductase

glutathione-S-transferase

Authors:

Vasilyeva E.F.

Mental Health Research Center

ORCID: 0000-0002-0218-833X

Savushkina O.K.

Mental Health Research Center

ORCID: 0000-0002-5996-6606

Prokhorova T.A.

Mental Health Research Center

ORCID: 0000-0002-3574-2165

Tereshkina E.B.

Mental Health Research Center

ORCID: 0000-0002-4784-8995

Boksha I.S.

Mental Health Research Center

ORCID: 0000-0003-1369-8658

Sizov S.V.

Mental Health Research Center

ORCID: 0000-0002-8213-5122

Oleichik I.V.

Mental Health Research Center

ORCID: 0000-0002-8344-0620

Received:

26.12.2023

Accepted:

22.03.2024

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References:

Kroken RA, Sommer IE, Steen VM, et al. Constructing the Immune Signature of Schizophrenia for Clinical Use and Research; An Integrative Review Translating Descriptives Into Diagnostics. Front Psychiatry. 2019;9:753. https://doi.org/10.3389/fpsyt.2018.00753
Takahashi V, Yu Z, Sakai Mai, et al. Linking Activation of Microglia and Peripheral Monocytic Cells to the Pathophysiology of Psychiatric Disorders. Front. Cell. Neurosci. 2016;10:144. https://doi.org/10.3389/fncel.2016.00144
Jackson AJ, Miller BJ. Meta-analysis of total and differential white blood cell counts in schizophrenia. Acta psychiatrica Scandinavica. 2020;142(1):18-26. https://doi.org/10.1111/acps.13140
Drexhage RC, Knijff EM, Padmos RC, et al. The mononuclear phagocyte system and its cytokine in ammatory networks in schizophrenia and bipolar disorder. Expert Rev Neurother. 2010;10(1):59-76. https://doi.org/10.1586/ern.09.144
Ferrari P, Parisi MM, Colombo R, et al. Depression and Mania Induce Pro-inflammatory Activation of Macrophages Following Application of Serum From Individuals With Bipolar Disorder. Clin Psychopharmacol Neurosci. 2018;16(1):103-108. https://doi.org/10.9758/cpn.2018.16.1.103
Simon MS, Schiweck C, Arteaga-Henríquiz G, et al. Monocyte mitochondrial dysfunction, inflammaging, and inflammatory pyroptosis in major depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2021;111;110391. https://doi.org/10.1016/j.pnpbp.2021.110391
Aichholzer M, Gangadin SS, Sommer IEC, et al. Inflammatory monocyte gene signature predicts beneficial within group effect of simvastatin in patients with schizophrenia spectrum disorders in a secondary analysis of a randomized controlled trial. Brain Behav Immun Health. 2022;26:100551. https://doi.org/10.1016/j.bbih.2022.100551
Vasilyeva EF, Sekirina TP, Sarmanova ZV, et al. Estimation of level of subpopulation CD14+/CD16+ monocytes in patients with juvenile depressions. Medical Immunolog. 2019;21(2):257-268. (In Russ.). https://doi.org/10.15789/1563-0625-2019-2-257-268
Vasilyeva EF, Oleychik IV, Baranov PA, et al. Evaluation of the levels of proinflammatory activity of monocytes in depressed patients with schizophrenia. S.S. Korsakov Journal of Neurologiy and Psychiatry. 2022;122(11):131-136. (In Russ.). https://doi.org/10.17116/jnevro2022122111131
Babkina II, Sergeeva SP, Gorbacheva LR. The Role of NF-κB in Neuroinflammation. Neurochem. J. 2021;15:114-128. https://doi.org/10.1134/S1819712421020045
Orrico F, Laurance S, Lopez AC, et al. Oxidative Stress in Healthy and Pathological Red Blood Cells. Biomolecules. 2023;13(8):1262. https://doi.org/10.3390/biom13081262
Ramendra R, Mancini M, Ayala JM, et al. Glutathione Metabolism Is a Regulator of the Acute Inflammatory Response of Monocytes to (1→3)-β-D-Glucan. Front Immunol. 2021;12:694152. https://doi.org/10.3389/fimmu.2021.694152
Tereshkina EB, Savushkina OK, Boksha IS, et al. Glutathione reductase and glutathione-S-transferase in blood cells in schizophrenia and schizophrenia spectrum disorders. S.S. Korsakov Journal of Neurologiy and Psychiatry. 2019;119(2):61-65. (In Russ.). https://doi.org/10.17116/jnevro201911902161
Savushkina OK, Boksha IS, Omel’chenko MA, et al. Correlations of biochemical and clinical parameters in patients at risk for schizophrenic spectrum diseases. Vestnik Nevrologii, Psikhiatrii i Neyrokhirurgii. 2023;3:213-224. (In Russ.). https://doi.org/10.33920/med-01-2303-06
Prokhorova TA, Tereshkina EB, Savushkina OK, et al. The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode. S.S. Korsakov Journal of Neurologiy and Psychiatry. 2019;119(4):47-54. (In Russ.). https://doi.org/10.17116/jnevro201911904147
Spickett CM, Smith WE, Reglinski J, et al. Oxidation of erythrocyte glutathione by monocytes stimulated with interleukin-6. Analysis by 1H spin echo NMR. Clin Chim Acta. 1998;270(2):115-124. https://doi.org/10.1016/s0009-8981(97)00210-6
Vasilyeva EF, Sekirina TP, Omelchenko MA, et al. A comparative analysis of two methods for assessing the proinflammatory activity of monocytes in patients with juvenile depression. S.S. Korsakov Journal of Neurologiy and Psychiatry. 2021;121(11):61-66. (In Russ.). https://doi.org/10.17116/jnevro202112111161
Tsugawa S, Noda Y, Tarumi R, et al. Glutathione levels and activities of glutathione metabolism enzymes in patients with schizophrenia: A systematic review and meta-analysis. J Psychopharmacol. 2019;33(10):1199-1214. https://doi.org/10.1177/0269881119845820
Ermakov EA, Dmitrieva EM, Parshukova DA, et al. Oxidative Stress-Related Mechanisms in Schizophrenia Pathogenesis and New Treatment Perspectives. Oxid Med Cell Longev. 2021;2021:8881770. https://doi.org/10.1155/2021/8881770
Maurya PK, Rizvi SI. Age-dependent changes in glutathione-s-transferase: correlation with total plasma antioxidant potential and red cell intracellular glutathione. Indian J Clin Biochem. 2010;25(4):398-400. https://doi.org/10.1007/s12291-010-0047-5