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Saltanova V.A.

Tyumen State Medical University;
Regional clinical hospital No. 2

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

Doyan Yu.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Mazurov N.A.

Tyumen State Medical University

Genetic basis of postoperative cognitive dysfunction

Authors:

Saltanova V.A., Kicherova O.A., Reikhert L.I., Doyan Yu.I., Mazurov N.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4): 43‑47

DOI: 10.17116/jnevro202412404143

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To cite this article:

Saltanova VA, Kicherova OA, Reikhert LI, Doyan YuI, Mazurov NA. Genetic basis of postoperative cognitive dysfunction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(4):43‑47. (In Russ.)
https://doi.org/10.17116/jnevro202412404143

 
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This review highlights literature data on potential genetic markers that potentially influence the development of postoperative cognitive dysfunction, such as TOMM40, APOE, TREM2, METTL3, PGC1a, HMGB1 and ERMN. The main pathogenetic mechanisms triggered by these genes and leading to the development of cognitive impairment after anesthesia are described. The paper systematizes previously published works that provide evidence of the impact of specific genetic variants on the development of postoperative cognitive dysfunction.

Keywords:

postoperative cognitive dysfunction
long-term anesthesia

Authors:

Saltanova V.A.

Tyumen State Medical University;
Regional clinical hospital No. 2

Kicherova O.A.

Tyumen State Medical University

Reikhert L.I.

Tyumen State Medical University

Doyan Yu.I.

Tyumen State Medical University;
Regional Clinical Hospital No. 2

Mazurov N.A.

Tyumen State Medical University

Received:

20.12.2023

Accepted:

20.12.2023

List of references:

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