The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry

Kalinin V.V.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-9546-5852

Zemlyanaya A.A.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-6570-6977

Subbotin K.Y.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-8091-802X

The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry

Authors:

Kalinin V.V., Zemlyanaya A.A., Subbotin K.Y.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2): 37‑44

DOI: 10.17116/jnevro202412402137

Downloaded: 13

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To cite this article:

Kalinin VV, Zemlyanaya AA, Subbotin KY. The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2):37‑44. (In Russ.)
https://doi.org/10.17116/jnevro202412402137

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

To identify the possible influence of cellular immunity parameters and neurobiological variables (frequency of seizures of various semiotics and their severity) on comorbid psychopathological symptoms depending on the profile of interhemispheric asymmetry in patients with focal forms of epilepsy.

MATERIAL AND METHODS

The study included 92 patients with epilepsy (38 men, 54 women, mean age 38.7+8.45 years). Focal temporal lobe epilepsy was diagnosed in 36 patients, focal frontal lobe epilepsy in 16 patients, and temporal-frontal lobe epilepsy in 40 patients. For each type of seizure, severity was assessed according to the National Seizure Severity Scale (NHS3). The mental status of patients was assessed using the SCL-90 self-report questionnaire. The Annette scale was used to assess the profile of interhemispheric asymmetry. The number of different clusters of lymphocytes was studied, including the number of T-lymphocytes (CD3+), T-helpers (CD3+CD4+), T-cytotoxic (CD3+CD8+), T-NK (natural killers CD3+CD16+CD56+), B-lymphocytes (CD3–CD19+), as well as immunoregulatory index (CD4/CD8 ratio). In order to identify any possible relationships between neurobiological and immune variables, on the one hand, and the SCL-90 constructs, on the other hand, a separate correlation analysis of Spearman ranks within the left-handed group and the right-handed group was carried out.

RESULTS

We revealed the differences between groups of patients with epilepsy with right and left profiles of hemispheric asymmetry regarding the relationship between the frequency of seizures, their severity and accompanying psychopathological variables, on the one hand, and between immunity indices and psychopathological constructs, on the other hand. It has been established that neurobiological and immune variables in left-handers can determine the psychopathological structure of the comorbid mental disorder.

CONCLUSION

Prediction of concomitant psychopathological syndromes in patients with epilepsy on the basis of clinical data and data on immunity is quite possible, but only in left-handed patients.

Keywords:

neuroimmunology

psychopathology in epilepsy

profile of hemispheric asymmetry

Authors:

Kalinin V.V.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-9546-5852

Zemlyanaya A.A.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-6570-6977

Subbotin K.Y.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-8091-802X

Received:

05.06.2023

Accepted:

18.09.2023

List of references:

Josephson CB, Jetté N. Psychiatric comorbidities in epilepsy. Int Rev Psychiatry. 2017;29(5):409-424. Epub 2017 Jul 6. PMID: 28681667. https://doi.org/10.1080/09540261.2017.1302412
Mula M, Kanner AM, Jetté N, Sander JW. Psychiatric Comorbidities in People With Epilepsy. Neurol Clin Pract. 2021;11(2):e112-e120. PMID: 33842079; PMCID: PMC8032418. https://doi.org/10.1212/CPJ.0000000000000874
Altshuler LL, Devinsky O, Post RM, Theodore W. Depression, anxiety and temporal lobe epilepsy. Laterality of focus and symptoms. Archives of Neurology. 1990;47:284-288.
Schraegle WA, Titus JB. The relationship of seizure focus with depression, anxiety, and health-related quality of life in children and adolescents with epilepsy. Epilepsy Behav. 2017;68:115-122. Epub 2017 Jan 28. PMID: 28142130. https://doi.org/10.1016/j.yebeh.2016.12.009
Kanner AM. Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry. 2003;54(3):388-98. PMID: 12893113. https://doi.org/10.1016/s0006-3223(03)00469-4
Jansen C, Francomme L, Vignal JP, et al. Interictal psychiatric comorbidities of drug-resistant focal epilepsy: Prevalence and influence of the localization of the epilepsy. Epilepsy Behav. 2019;94:288-296. Epub 2018 Nov 11. PMID: 30429057. https://doi.org/10.1016/j.yebeh.2018.06.046
Schmitz B. Depressive disorders in epilepsy. In: M. Trimble, B. Schmitz (eds.), Seizures, affective disorders and anticonvulsant drugs. Clarius Press. 2002;19-34.
Schmitz B. Depression and mania in patients with epilepsia. Epilepsia, 2005;46:45-49. Vedhara K., Irwin M. Human psychoneuroimmunology. Oxford University Press, Oxford; 2005;356.
Vinti V, Dell’Isola GB, Tascini G, et al. Temporal Lobe Epilepsy and Psychiatric Comorbidity. Front Neurol. 2021;12:775781.775781. PMID: 34917019; PMCID: PMC8669948. https://doi.org/10.3389/fneur.2021.775781
Kobylarek D, Iwanowski P, Lewandowska Z, et al. Advances in the Potential Biomarkers of Epilepsy. Front Neurol. 2019;10:685. https://doi.org/10.3389/fneur.2019.00685
Mazarati AM, Lewis ML, Pittman QJ. Neurobehavioral comorbidities of epilepsy: Role of inflammation. Epilepsia. 2017;58(suppl 3):48-56. PMID: 28675557. https://doi.org/10.1111/epi.13786
Flammer J, Neziraj T, Rüegg S, Pröbstel AK. Immune Mechanisms in Epileptogenesis: Update on Diagnosis and Treatment of Autoimmune Epilepsy Syndromes. Drugs. 2023;83(2):135-158. Epub 2023 Jan 25. PMID: 36696027; PMCID: PMC9875200. https://doi.org/10.1007/s40265-022-01826-9
Kiecolt-Glaser JK, McGuire L, Robles TF, Glaser R. Psychoneuroimmunology and psychosomatic medicine: back to the future. Psychosom Med. 2002;64(1):15-28. PMID: 11818582. https://doi.org/10.1097/00006842-200201000-00004
Birnbaum G. Introduction to immunology. Antel In: J., Birnbaum G., Hartung H.P. (eds). Clinical neuroimmunology. Blackwell Science Ltd, London, second edition. 2005;1-12.
Nutma E, Willison H, Martino G, Amor S. Neuroimmunology — the past, present and future. Clin Exp Immunol. 2019;197(3):278-293. Epub 2019 Mar 11. PMID: 30768789; PMCID: PMC6693969. https://doi.org/10.1111/cei.13279
Kalinin VV, Subbotin KY, Yermakova NG. The interrelationship between clinical and immunity variables in epilepsy. J Epileptology. 2016;24:95-104.
Kalinin VV, Subbotin KY, Yermakova NG. Alexithymia: relationships with neurobiological and immune variables in patients with epilepsy. In: Teixeira R.J., Bermond B., Moormann P.P. (eds.). Current developments in alexithymia: A cognitive and affective deficit. Nova Science Publishers. 2018;121-130.
Knecht S, Dräger B, Deppe M, et al. Handedness and hemispheric language dominance in healthy humans. Brain. 2000;123:2512-2518.
Geschwind N, Behan P. Left-handedness: association with immune disease, Migraine, and developmental learning disorder. Proc National Academy of Sciences. 1982;79:5097-5100.
Geschwind N, Galaburda A. Cerebral Lateralization. Biological mechanisms, associations and pathology: I. a hypothesis and program for research. Arch Neurol. 1985;42:428-459.
Geschwind N, Galaburda A. Cerebral Lateralization. BiologVladimir V. Kalinin et al. 45 ical mechanisms, associations and pathology: II. a hypothesis and program for research. Arch Neurol. 1985b;42:521-552.
Kalinin VV, Zemlyanaya AA, Krylov OE, et al. Handedness, alexithymia, and focus laterality as risk factors for psychiatric comorbidity in patients with epilepsy. Epilepsy & Behavior. 2010;17:389-394.
Kalinin VV, Nazmetdinova DM, Basamygin AV. Handedness, cognitive processing and intelligence in patients with epilepsy. J Epileptology. 2014;22:26-32.
Fisher R, Cross JH, French JA, et al. Operational classification of seizure types by the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:522-530.
O’Donoghue MF, Duncan JS, Sander JW. The National Hospital Seizure Severity Scale: a further development of the Chalfont Seizure Severity Scale. Epilepsia. 1996;37:563-571.
Derogatis LR, Cleary PA. Confirmation of the dimensional structure of SCL-90: a study of construct validation. J Clin Psychol. 1977;33:981-989.
Derogatis LR, Lipman R, Covi L. SCL-90: an outpatient psychiatric rating scale: preliminary report. Psychopharmacol Bull. 1973;9:13-28.
Kalinin VV, Zemlyanaya AA, Zheleznova EV, et al. Neurobiological and clinical predictors of remission and antiepileptic treatment efficacy in partial epilepsies. J Epileptology. 2013;21:23-33.
Annett M. A classification of hand preference by association analysis. British Journal of Psychology. 1970;61:303-321.
Feinstein AR. Principles of medical statistics. Boca Raton, Chapman & Hall/CRC. 2002;701.
Mathews DE, Farewell VT. Using and Understanding Medical Statistics. Karger, Basel. 2007;322.
Hardyck C, Petrinovich LF. Left-handedness. Psychol Bull. 1977;84:385-404.
Brackenbridge CJ. Secular variation in handedness over ninety years. Neuropsychologia. 1981;19:493-508.
Raymond M, Pontier D, Doufour AB, et al. Frequency-dependent maintenance of left-handedness in humans. Proc Biol Sci. 1996;263:1627-1633.
McManus IC. The history and geography of human handedness. In: Sommer I.E.C., Kahn R.S. (eds.). Language lateralization and psychosis. Cambridge University Press. 2009;37-57.
McKeever WF, Riche DA. Left-handedness and immune disorders. Cortex. 1990;26:33-40.
Bryden PJ, Bruyn J, Fletcher P. Handedness and health: an examination of the association between different handedness classifications and health disorders. Laterality. 2005;10:429-440.
Bryden MP, McManus IC, Bulman-Fleming MB. Evaluating the empirical support for the Geschwind-Behan-Galaburda model of cerebral lateralization. Brain Cogn. 1994;26(2):103-167.

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