The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry

Kalinin V.V.; Zemlyanaya A.A.; Subbotin K.Y.

doi:https://doi.org/10.17116/jnevro202412402137

Kalinin V.V.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-9546-5852

Zemlyanaya A.A.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-6570-6977

Subbotin K.Y.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-8091-802X

The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry

Authors:

Kalinin V.V., Zemlyanaya A.A., Subbotin K.Y.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2): 37‑44

DOI: 10.17116/jnevro202412402137

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To cite this article:

Kalinin VV, Zemlyanaya AA, Subbotin KY. The relationship between immunological and psychopathological characteristics in patients with focal epilepsy depending on the profile of interhemispheric asymmetry. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;124(2):37‑44. (In Russ.)
https://doi.org/10.17116/jnevro202412402137

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To identify the possible influence of cellular immunity parameters and neurobiological variables (frequency of seizures of various semiotics and their severity) on comorbid psychopathological symptoms depending on the profile of interhemispheric asymmetry in patients with focal forms of epilepsy.

MATERIAL AND METHODS

The study included 92 patients with epilepsy (38 men, 54 women, mean age 38.7+8.45 years). Focal temporal lobe epilepsy was diagnosed in 36 patients, focal frontal lobe epilepsy in 16 patients, and temporal-frontal lobe epilepsy in 40 patients. For each type of seizure, severity was assessed according to the National Seizure Severity Scale (NHS3). The mental status of patients was assessed using the SCL-90 self-report questionnaire. The Annette scale was used to assess the profile of interhemispheric asymmetry. The number of different clusters of lymphocytes was studied, including the number of T-lymphocytes (CD3+), T-helpers (CD3+CD4+), T-cytotoxic (CD3+CD8+), T-NK (natural killers CD3+CD16+CD56+), B-lymphocytes (CD3–CD19+), as well as immunoregulatory index (CD4/CD8 ratio). In order to identify any possible relationships between neurobiological and immune variables, on the one hand, and the SCL-90 constructs, on the other hand, a separate correlation analysis of Spearman ranks within the left-handed group and the right-handed group was carried out.

RESULTS

We revealed the differences between groups of patients with epilepsy with right and left profiles of hemispheric asymmetry regarding the relationship between the frequency of seizures, their severity and accompanying psychopathological variables, on the one hand, and between immunity indices and psychopathological constructs, on the other hand. It has been established that neurobiological and immune variables in left-handers can determine the psychopathological structure of the comorbid mental disorder.

CONCLUSION

Prediction of concomitant psychopathological syndromes in patients with epilepsy on the basis of clinical data and data on immunity is quite possible, but only in left-handed patients.

Keywords:

neuroimmunology

psychopathology in epilepsy

profile of hemispheric asymmetry

Authors:

Kalinin V.V.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-9546-5852

Zemlyanaya A.A.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-6570-6977

Subbotin K.Y.

Moscow Research Institute of Psychiatry — Serbsky National Medical Research Center for Psychiatry and Narcology

ORCID: 0000-0001-8091-802X

Received:

05.06.2023

Accepted:

18.09.2023

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