Real-world clinical efficacy assessment of Kapsikam a combined topical medication based on nonivamide synthetic capsaicin analog in patients with acute nonspecific musculoskeletal back pain: LOCUS observational study outcomes

Solovieva E.Yu.; Baranova O.A.

doi:https://doi.org/10.17116/jnevro202112110172

Solovieva E.Yu.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-1256-2695

Baranova O.A.

Pirogov Russian National Research Medical University

Real-world clinical efficacy assessment of Kapsikam a combined topical medication based on nonivamide synthetic capsaicin analog in patients with acute nonspecific musculoskeletal back pain: LOCUS observational study outcomes

Authors:

Solovieva E.Yu., Baranova O.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10): 72‑77

DOI: 10.17116/jnevro202112110172

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To cite this article:

Solovieva EYu, Baranova OA. Real-world clinical efficacy assessment of Kapsikam a combined topical medication based on nonivamide synthetic capsaicin analog in patients with acute nonspecific musculoskeletal back pain: LOCUS observational study outcomes. S.S. Korsakov Journal of Neurology and Psychiatry. 2021;121(10):72‑77. (In Russ.)
https://doi.org/10.17116/jnevro202112110172

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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OBJECTIVE

Evaluation of the effect of local therapy with Kapsikam on the dynamics of clinical symptoms and indices of the disability scale, as well as on reducing the doses of systemic non-steroidal anti-inflammatory drugs (NSAIDs) used in patients with acute back pain (LOCUS study).

MATERIALS AND METHODS

An observational study included 120 patients with nonspecific pain in the lower back and a verified diagnosis of Lumbodynia M54.5; «Lumbodynia with sciatica» M54.4, of which 78 received in addition to the basic treatment with systemic NSAIDs topical drug Kapsikam and 42 — only basic treatment.

Results and conclusion. The addition of Kapsikam ointment to systemic NSAIDs accelerated the onset of the analgesic effect, which made it possible to discontinue NSAIDs in 50% of patients after 5 days of use. Local therapy was accompanied by easily tolerated adverse events that did not affect the use of the drug. 97.4% of patients used the study drug as prescribed until the end of the study.

Keywords:

acute musculoskeletal back pain

topical medications

nonivamid

nonsteroidal anti-inflammatory drugs

Authors:

Solovieva E.Yu.

Pirogov Russian National Research Medical University

ORCID: 0000-0003-1256-2695

Baranova O.A.

Pirogov Russian National Research Medical University

Received:

23.08.2021

Accepted:

13.09.2021

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References:

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