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Pronin I.N.

Burdenko Neurosurgical Center

Khokhlova E.V.

Burdenko National Medical Scientific Center for Neurosurgery

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Maryashev S.A.

Burdenko National Medical Scientific Center for Neurosurgery

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Batalov A.I.

Burdenko Neurosurgical Center

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Positron emission tomography with 11C-methionine in primary brain tumor diagnosis

Authors:

Pronin I.N., Khokhlova E.V., Konakova T.A., Maryashev S.A., Pitskhelauri D.I., Batalov A.I., Postnov A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8): 51‑56

DOI: 10.17116/jnevro202012008151

Views: 10012

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To cite this article:

Pronin IN, Khokhlova EV, Konakova TA, Maryashev SA, Pitskhelauri DI, Batalov AI, Postnov AA. Positron emission tomography with 11C-methionine in primary brain tumor diagnosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(8):51‑56. (In Russ.)
https://doi.org/10.17116/jnevro202012008151

 
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OBJECTIVE

To investigate the variations in 11C-methionine uptake in the intact brain tissue and in glial brain tumors of different types.

MATERIAL AND METHODS

Forty patients (21 men, 19 women) with gliomas, Grade I-IV, underwent 11C-methionine PET-CT and contrast-enhanced MRI. Standardized uptake value (SUV), tumor-to-normal (T/N) ratios and tumor volume were analyzed.

RESULTS

The high inter-subject variability was detected in the intact brain tissue (SUV in the frontal lobe (FL) varies from 0.47 to 1.73). Amino acid metabolism was more active in women than in men (FL SUV 1.32±0.22 and 1.05±0.24, respectively). T/N ratio better differentiates gliomas by the degree of anaplasia compared to SUV. Gliomas of Grade III (T/N=2.64±0.98) were significantly different (p<0.05) from those of Grade IV (T/N=3.83±0.75). The lowest level of methionine uptake was detected in diffuse astrocytomas (T/N=1.52±0.57), which was lower than with anaplastic astrocytomas (T/N=2.34±0.77, p<0.05).

CONCLUSIONS

11C-methionine PET-CT was informative in the high/low degree of malignancy differentiation (T/N 1.66±0.71 for Grade I-II and 3.18±1.06 for Grade III-IV, p<0.05). The method was also useful in separating astrocytomas of Grade II and III. The considerable variation of SUV in the intact brain tissue as well as the difference in uptake between selected areas of the brain were revealed.

Keywords:

11C-methionine PET-CT
brain tumors
differential diagnosis of gliomas

Authors:

Pronin I.N.

Burdenko Neurosurgical Center

Khokhlova E.V.

Burdenko National Medical Scientific Center for Neurosurgery

Konakova T.A.

Burdenko National Medical Scientific Center for Neurosurgery

Maryashev S.A.

Burdenko National Medical Scientific Center for Neurosurgery

Pitskhelauri D.I.

Skolkovo Institute of Science and Technology

Batalov A.I.

Burdenko Neurosurgical Center

Postnov A.A.

Burdenko National Medical Scientific Center for Neurosurgery;
National Research Nuclear University MEPhI (Moscow Engineering Physics Institute);
Lebedev Physical Institute of the Russian Academy of Sciences

Received:

13.07.2019

Accepted:

08.08.2019

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