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Gasanov R.F.

Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia

Makarov I.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, Sankt-Peterburg

Emelina D.A.

Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia

Cognitive deficit in children with hyperkinetic disorder

Authors:

Gasanov R.F., Makarov I.V., Emelina D.A.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(3): 126‑131

DOI: 10.17116/jnevro2020120031126

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COGNITIVE DEFICIT IN CHILDREN WITH HYPERKINETIC DISORDER
COGNITIVE DEFICIT IN CHILDREN WITH HYPERKINETIC DISORDER

To cite this article:

Gasanov RF, Makarov IV, Emelina DA. Cognitive deficit in children with hyperkinetic disorder. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(3):126‑131. (In Russ.)
https://doi.org/10.17116/jnevro2020120031126

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The review presents current data on the nature of cognitive deficit in children with hyperkinetic disorder, and possible pathophysiological mechanisms of the disease. Considering possible neurobiological components of hyperkinetic disorder, attention is given to pathological functional connections underlying specific clinical manifestations of the disease.

Keywords:

hyperkinetic disorder
cognitive deficit
executive functions
working memory
impulsivity
attention deficit

Authors:

Gasanov R.F.

Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia

Makarov I.V.

Sankt-Peterburgskiĭ nauchno-issledovatel'skiĭ psikhonevrologicheskiĭ institut im. V.M. Bekhtereva, Sankt-Peterburg

Emelina D.A.

Bekhterev Psychoneurological Research Institute, St. Petersburg, Russia

List of references:

  1. Elosúa MR, Olmo S Del, Contreras MJ. Differences in Executive Functioning in Children with Attention Deficit and Hyperactivity Disorder (ADHD). Front Psychol. 2017;(8):976. https://doi.org/10.3389/fpsyg.2017.00976
  2. Shahrokhi H, Tehrani-Doost M, Shahrivar Z, Farhang S, Amiri S. Deficits of Executive Functioning in Conduct Disorder and Attention Deficit/Hyperactivity Disorder. Ann Psychiatry Treatm. 2017;2(1):13-20. https://doi.org/10.17352/apt.000006
  3. Van Ewijk H, Heslenfeld DJ, Zwiers MP, Buitelaar JK, Oosterlaan J. Diffusion tensor imaging in attention deficit/hyperactivity disorder: a systematic review and meta-analysis. Neurosci Biobehav. 2012;36(4):1093-1106. https://doi.org/10.1016/j.neubiorev.2012.01.003
  4. Nakao T, Radua J, Rubia K, Mataix-Cols D. Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. Am J Psychiatry. 2011;168(11):1154-1163. https://doi.org/10.1176/appi.ajp.2011.11020281
  5. Seidman LJ, Biederman J, Liang L, Valera EM, Monuteaux MC, Brown A, Kaiser J, Spencer T, Faraone SV, Makris N. Gray matter alterations in adults with attention-deficit/hyperactivity disorder identified by voxel based morphometry. Biol Psychiatry. 2011;69(9):857-866. https://doi.org/10.1016/j.biopsych.2010.09.053
  6. Hoogman M, Bralten J, Hibar DP, Mennes M, Zwiers MP, Schweren LSJ, van Hulzen KJE, Medland SE, Shumskaya E, Jahanshad N, Zeeuw P, Szekely E, Sudre G, Wolfers T, Onnink AMH, Dammers JT, Mostert JC, Vives-Gilabert Y, Kohls G, Oberwelland E, Seitz J, Schulte-Rüther M, Ambrosino S, Doyle AE, Høvik MF, Dramsdahl M, Tamm L, van Erp TGM, Dale A, Schork A, Conzelmann A, Zierhut K, Baur R, McCarthy H, Yoncheva YN, Cubillo A, Chantiluke K, Mehta MA, Paloyelis Y, Hohmann S, Baumeister S, Bramati I, Mattos P, Tovar-Moll F, Douglas P, Banaschewski T, Brandeis D, Kuntsi J, Asherson P, Rubia K, Kelly C, Martino AD, Milham MP, Castellanos FX, Frodl T, Zentis M, Lesch KP, Reif A, Pauli P, Jernigan TL, Haavik J, Plessen KJ, Lundervold AJ, Hugdahl K, Seidman LJ, Biederman J, Rommelse N, Heslenfeld DJ, Hartman CA, Hoekstra PJ, Oosterlaan J, Polier GV, Konrad K, Vilarroya O, Ramos-Quiroga JA, Soliva JC, Durston S, Buitelaar JK, Faraone SV, Shaw P, Thompson PM, Franke B. Subcortical brain volume differences in participants with attention deficit hyperactivity disorder in children and adults: a cross-sectional mega-analysis. Lancet Psychiatry. 2017;4(4):310-319. https://doi.org/10.1016/s2215-0366(17)30200-6
  7. Fusar-Poli P, Rubia K, Rossi G, Sartori G, Balottin U. Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysis. Am J Psychiatry. 2012;169(3):264-272. https://doi.org/10.1176/appi.ajp.2011.11060940
  8. Cortese S. The neurobiology and genetics of attention-deficit/hyperactivity disorder (ADHD): what every clinician should know. Eur J Paediatr Neurol. 2012;16(5):422-433. https://doi.org/10.1016/j.ejpn.2012.01.009
  9. Maltezos S, Horder J, Coghlan S, Skirrow C, O’Gorman R, Lavender TJ, Mendez MA, Mehta M, Daly E, Xenitidis K, Paliokosta E, Spain D, Pitts M, Asherson P, Lythgoe DJ, Barker GJ, Murphy DG. Glutamate/glutamine and neuronal integrity in adults with ADHD: a proton MRS study. Transl Psychiatry. 2014;4:e373. https://doi.org/10.1038/tp.2014.11
  10. Blum K, Chen AL, Braverman ER, Comings DE, Chen TJH, Arcuri V, Blum SH, Downs BW, Waite RL, Notaro A, Lubar JF, Williams L, Prihoda T, Palomo T, Oscar-Berman M. Attention-deficit-hyperactivity disorder and reward deficiency syndrome. Neuropsychiatr Dis Treat. 2008;4(5):893-917. https://doi.org/10.2147/NDT.S2627
  11. Potter AS, Schaubhut G, Shipman M. Targeting the nicotinic cholinergic system to treat attention-deficit/hyperactivity disorder: rationale and progress to date. CNS Drugs. 2014;28(12):1103-1113. https://doi.org/10.1007/s40263-014-0208-9
  12. Elia J, Glessner JT, Wang K, Takahashi N, Shtir CJ, Hadley D, Sleiman PM, Zhang H, Kim CE, Robison R, Lyon GJ, Flory JH, Bradfield JP, Imielinski M, Hou C, Frackelton EC, Chiavacci RM, Sakurai T, Rabin C, Middleton FA, Thomas KA, Garris M, Mentch F, Freitag CM, Steinhausen HC, Todorov AA, Reif A, Rothenberger A, Franke B, Mick EO, Roeyers H, Buitelaar J, Lesch KP, Banaschewski T, Ebstein RP, Mulas F, Oades RD, Sergeant J, Sonuga-Barke E, Renner TJ, Romanos M, Romanos J, Warnke A, Walitza S, Meyer J, Pálmason H, Seitz C, Loo SK, Smalley SL, Biederman J, Kent L, Asherson P, Anney RJ, Gaynor JW, Shaw P, Devoto M, White PS, Grant SF, Buxbaum JD, Rapoport JL, Williams NM, Nelson SF, Faraone SV, Hakonarson H. Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Nat Genet. 2011;44(1):78-84. https://doi.org/10.1038/ng.1013
  13. Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, Rohde LA, Sonuga-Barke EJS, Tannock R, Franke B. Attention-deficit/hyperactivity disorder. Nat Rev Dis Primers. 2015;1:15020. https://doi.org/10.1038/nrdp.2015.20
  14. Hart H, Radua J, Mataix-Cols D, Rubia K. Meta-analysis of fMRI studies of timing in attention-deficit hyperactivity disorder (ADHD). Neurosci Biobehav Rev. 2012;36(10):2248-2256. https://doi.org/10.1016/j.neubiorev.2012.08.003
  15. Cortese S, Castellanos FX, Eickhoff CR, D’Acunto G, Masi G, Fox PT, Laird AR, Eickhoff SB. Functional decoding and meta-analytic connectivity modeling in adult attention deficit/hyperactivity disorder. Biol Psychiatry. 2016;80(12):896-904. https://doi.org/10.1016/j.biopsych.2016.06.014
  16. Cocchi L, Bramati IE, Zalesky A, Furukawa E, Fontenelle LF, Moll J, Tripp G, Mattos P. Altered functional brain connectivity in a non-clinical sample of young adults with attention-deficit/hyperactivity disorder. J Neurosci. 2012;32(49):17753-17761. https://doi.org/10.1523/jneurosci.3272-12.2012
  17. Cortese S, Castellanos FX. Neuroimaging of attention-deficit/hyperactivity disorder: current neuroscience-informed perspectives for clinicians. Curr Psychiatry Rep. 2012;14(5):568-578. https://doi.org/10.1007/s11920-012-0310-y
  18. Barnett R. Attention deficit hyperactivity disorder. Lancet (London, England). 2016;387-737. https://doi.org/10.1016/s0140-6736(16)00332-9
  19. Becker SP, Langberg JM. Attention-deficit/hyperactivity disorder and sluggish cognitive tempo dimensions in relation to executive functioning in adolescents with ADHD. Child Psychiatry & Human Development. 2014;45(1):1-11. https://doi.org/10.1007/s10578-013-0372-z
  20. Spencer RC, Klein RM, Berridge CW. Psychostimulants act within the prefrontal cortex to improve cognitive performance. Biological Psychiatry. 2012;(72):221-227. https://doi.org/10.1016/j.biopsych.2011.12.002
  21. Chamberlain SR, Del Campo N, Dowson J., Müller U, Clark L, Robbins TW, Sahakian BJ. Atomoxetine improved response inhibition in adults with attention/deficit hyperactivity disorder. Biological Psychiatry. 2007;62(9):977-984. https://doi.org/10.1016/j.biopsych.2007.03.003
  22. Gau SS, Shang CY. Improvement of executive functions in boys with attention deficit hyperactivity disorder: an open-label follow-up study with once daily atomoxetine. International Journal of Neuropsychopharmacology. 2010;13(2):243-256. https://doi.org/10.1017/s1461145709990836
  23. Miyake A, Friedman NP, Emerson MJ, Witzki AH, Howerter A, Wager TD. The unity and diversity of executive functions and their contributions to complex «Frontal Lobe» tasks: A latent variable analysis. Cognitive Psychology. 2000;41(1):49-100. https://doi.org/10.1006/cogp.1999.0734
  24. Boonstra AM, Kooij JJ, Buitelaar JK, Oosterlaan J, Sergeant JA, Heister JGAMA, Franke B. An exploratory study of the relationship between four candidate genes and neurocognitive performance in adult ADHD. American Journal of Medical Genetics. 2008;147:397-402. https://doi.org/10.1002/ajmg.b.30595
  25. Mehta MA, Goodyer IM, Sahakian BJ. Methylphenidate improves working memory and set-shifting in AD/HD: relationship to basleine memory capacity. Journal of CLinical Psychol Psychiatry. 2004;45(2):293-305. https://doi.org/10.1111/j.1469-7610.2004.00221.x
  26. Coghill D, Rhodes SM, Matthews K. The neuropsychological effects of chronic methylphenidate on drug naive-boys with attention deficit/hyperactivity disorder. Biological Psychiatry. 2007;62:954-962. https://doi.org/10.1016/j.biopsych.2006.12.030
  27. Elliot R, Sahakian BJ, Matthews K, Bannerjea A, Rimmer J, Robbins TW. Effects of methylphenidate on spatial working memory and planning in healthy young adults. Psychopharmacology. 1997;131(2):196-206. https://doi.org/10.1007/s002130050284
  28. Turner DC, Robbins TW, Clark L, Aron AR, Dowson J, Sahakian BJ. Relative lack of cognitive effects of methylphenidate in eldery male volunteers. Psychopharmacology. 2003;168:455-464. https://doi.org/10.1007/s00213-003-1457-3
  29. Chamberlain SR, Robbins TW, Winder-Rhodes S, Müller U, Sahakian BJ, Blackwell AD, Barnett JH. Translational approaches to frontostriatal dysfunction in attention deficit/hyperactivity disorder using a computerized neuropsychological battery. Biological Psychiatry. 2011;69(12):1192-1203. https://doi.org/10.1016/j.biopsych.2010.08.019
  30. Chamberlain SR, Hampshire A, Muller U, Rubia K, del Campo N, Craig K, Regenthal R, Suckling J, Roiser JP, Grant JE, Bullmore ET, Robbins TW, Sahakian BJ. Atomoxetine modulates right inferior frontal activation during inhibitiory control: A pharmacological functional magnetic resonance imaging study. Biological Psychiatry. 2009;65(7):550-555. https://doi.org/10.1016/j.biopsych.2008.10.014
  31. Aron AR, Dowson J, Sahakian BJ, Robbins TW. Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry. 2003;54(12):1465-1468. https://doi.org/10.1016/s0006-3223(03)00609-7
  32. DeVito EE, Blackwell AD, Clark L, Kent L, Dezsery AM, Turner DC, Aitken MRF, Sahakian BJ. Methylphenidate improves response inhibition but not reflection impulsivity in children with attention deficit hyperactivity disorder (ADHD). Psychopharmacology. 2008;202(1-3):531-539. https://doi.org/10.1007/s00213-008-1337-y
  33. Chamberlain SR, Muller U, Blackwell AD, Clark L, Robbins TW, Sahakian BJ. Neurochemical modulation of response inhibition and probabilistic learning in humans. Science. 2006;311(5762):861-863. https://doi.org/10.1126/science.1121218
  34. Hampshire A, Chamberlain SR, Monti MM, Duncan J, Owen AM. The role of the right inferior frontal gyrus: Inhibition and attentional control. Neuroimage. 2010;50(3):1313-1319. https://doi.org/10.1016/j.neuroimage.2009.12.109
  35. Gau SS, Huang WL. Rapid visual information processing as a cognitive endophenotype of attention deficit hyperactivity disorder. Psychological Medicine. 2014;44(2):435-446. https://doi.org/10.1017/S0033291713000640
  36. Coull JT, Firth CD, Frackowiak RS, Grasby PM. A fronto-parietal network for rapid visual information processing: a PET study of sustained attention and working memory. Neuropsychologia. 1996;34(11):1085-1095. https://doi.org/10.1016/0028-3932(96)00029-2
  37. Hammerness P, Fried R, Petty CR, Meller B, Biederman J. Assessment of cognitive domains during treatment with OROS methylphenidate in adolescents with ADHD. Child Neuropsychology. 2013;20(3):319-327. https://doi.org/10.1080/09297049.2013.790359
  38. Turner DC, Blackwell AD, Dowson JH, McLean A, Sahakian BJ. Neurocognitive effects of methylphenidate in adults attention-deficit/hyperactivity disorder. Psychopharmacology. 2005;178(2-3):286-295. https://doi.org/10.1007/s00213-004-1993-5
  39. Ni H-C, Shang C-Y, Gau SS, Lin Y-J, Huang H-C, Yang L-K. A head-to-head randomized clinical trial of methylphenidate and atomoxetine treatment for executive function in adults with attention-deficit hyperactivity disorder. International Journal of Neuropsychopharmacology. 2013;16(9):1959-1973. https://doi.org/10.1017/S1461145713000357
  40. Nixon E. The social competence of children with attention deficit hyperactivity disorder: a review of the literature. Child Psychology and Psychiatry Review. 2001;(60):172-180. https://doi.org/10.1017/s1360641701002738
  41. Schutte V, Petermann F. Soziale Beziehungen und Partnerschaften bei Erwachsenen mit ADHS — eine Phanomenbeschreibung anhand einer Fragebogenstudie. Verhaltenstherapie & Verhaltensmedizin. 2006;27:157-172.
  42. Barkley RA. Behavioral inhibition, sustained attention, and executive function: constructing a unifying theory of ADHD. Psychological Bulletin. 1997;121(1):65-94. https://doi.org/10.1037/0033-2909.121.1.65
  43. Surman CB, Biederman BJ, Spencer T, Miller CA, McDermott KM, Faraone SV. Deficient Emotion Self-Regulation and Adult Attention Deficit Hyperactivity Disorder: A Family Risk Analysis. American Journal of Psychiatry. 2011;168(6):617-623. https://doi.org/10.1176/appi.ajp.2010.10081172
  44. Biederman J, Spencer T, Lomedico A, Day H, Petty CR, Faraone SV. Deficient emotional self-regulation and pediatric attention deficit hyperactivity disorder: A family risk analysis. Psychological Medicine. 2011;42(3):639-646. https://doi.org/10.1017/S0033291711001644
  45. Cortese S, Kelly C, Chabernaud C, Proal E, Di Martino A, Milham MP, Castellanos FX. Towards systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. American Journal of Psychiatry. 2012;169(10):1038-1055. https://doi.org/10.1176/appi.ajp.2012.11101521
  46. Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K. Meta-analysis of functional magnetic resonance imaging studies of inhibition and attention in attention-deficit/hyperactivity disorder: Exploring task-specific, stimulant medication, and age effects. Journal of the American Medical Association of Psychiatry. 2013;70(2):185-198. https://doi.org/10.1001/jamapsychiatry.2013.277
  47. Wolf RC, Plichta MM, Sambataro F, Fallgatter AJ, Jacob C, Lesch K-P, Herrmann MJ, Schönfeldt-Lecuona C, Connemann BJ, Grön G, Vasic N. Regional brain activation changes and abnormal functional connectivity of the ventrolateral prefrontal cortex during working memory processing in adults with attention-deficit/hyperactivity disorder. Human Brain Mapping. 2009;30(7):2252-2266. https://doi.org/10.1002/hbm.20665
  48. Willcutt EC, Doyle A, Nigg J, Faraone SV, Pennington BF. Validity of the executive function theory of attention-deficit/hyperactivity disorder: A meta-analytic review. Biological Psychiatry. 2005;57(11):1336-1346. https://doi.org/10.1016/j.biopsych.2005.02.006
  49. Nigg J, Casey BJ. An integrative theory of attention-deficit/hyperactivity disorder based on the cognitive and affective neurosciences. Development and Psychopathology. 2005;17(3):785-806. https://doi.org/10.1017/s0954579405050376
  50. Zelaznik HN, Vaughn AJ, Green JT, Smith AL, Hoza B, Linnea K. Motor timing deficits in children with attention-deficit/hyperactivity disorder. Human Movement Science. 2012;31(1):255-265. https://doi.org/10.1016/j.humov.2011.05.003
  51. Suskauer SJ, Simmonds DJ, Fotedar S, Blankner JG, Pekar JJ, Denckla MB, Mostofsky SH. Functional magnetic resonance imaging evidence for abnormalities in response selection in attention deficit hyperactivity disorder: Differences in activation associated with response inhibition but not habitual motor response. Journal of Cognitive Neuroscience. 2008;(20):478-493. https://doi.org/10.1162/jocn.2008.20032
  52. Sagvolden T, Aase H, Zeiner P, Berger D. Altered reinforcement mechanisms in attention-deficit/hyperactivity disorder. Behav Brain Res. 1998;94(1):61-71. https://doi.org/10.1016/s0166-4328(97)00170-8
  53. Scheres A, Milham MP, Knutson B, Castellanos FX. Ventral striatal hyporesponsiveness during reward anticipation in attention-deficit/hyperactivity disorder. Biological Psychiatry. 2007;61(5):720-724. https://doi.org/10.1016/j.biopsych.2006.04.042
  54. Bush G. Cingulate, frontal, and parietal cortical dysfunction in attentiondeficit hyperactivity disorder. Biological Psychiatry. 2011;69(12):1160-1167. https://doi.org/10.1016/j.biopsych.2011.01.022
  55. Faraone SV. The pharmacology of amphetamine and methylphenidate: Relevance to the neurobiology of attention deficit/hyperactivity disorder and other psychiatric comorbidities. Neuroscience and Biobehavioral Reviews. 2018;87:255-270. https://doi.org/10.1016/j.neubiorev.2018.02.001

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