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Gareeva A.E.

Bashkir State Medical University, Ufa, Russia;
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia

Sharafiev R.R.

Bashkir State Medical University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Nasibullin T.R.

FGBUN «Institut biohimii i genetiki», Ufa

Fakhurtdinova Z.R.

Bashkir State University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

The combined effect of genetic factors and attention deficit hyperactivity disorder on the development of dependence on synthetic cannabinoids

Authors:

Gareeva A.E., Sharafiev R.R., Akhmetova E.A., Nasibullin T.R., Fakhurtdinova Z.R., Yuldashev V.L., Asadullin A.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2): 15‑21

DOI: 10.17116/jnevro202012002115

Read: 4284 times

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Table of contents

THE COMBINED EFFECT OF GENETIC FACTORS AND ATTENTION DEFICIT HYPERACTIVITY DISORDER ON THE DEVELOPMENT OF DEPENDENCE ON SYNTHETIC CANNABINOIDS
THE COMBINED EFFECT OF GENETIC FACTORS AND ATTENTION DEFICIT HYPERACTIVITY DISORDER ON THE DEVELOPMENT OF DEPENDENCE ON SYNTHETIC CANNABINOIDS

To cite this article:

Gareeva AE, Sharafiev RR, Akhmetova EA, Nasibullin TR, Fakhurtdinova ZR, Yuldashev VL, Asadullin AR. The combined effect of genetic factors and attention deficit hyperactivity disorder on the development of dependence on synthetic cannabinoids. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2):15‑21. (In Russ.)
https://doi.org/10.17116/jnevro202012002115

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
 
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Abstract:

Objective. To develop a model of assessment of individual risk of dependence on synthetic cannabinoids based on genetic factors and diagnosis of attention deficit hyperactivity disorder (ADHD). Material and methods. The study included 146 male adolescents using synthetic cannabinoids and 136 healthy people. The genetic study considered the combination of dependence on synthetic cannabinoids and ADHD. Six polymorphisms in the genes of dopaminergic and serotonergic systems were genotyped. Results and conclusion. In general, the results of this work confirm the important role of the dopaminergic and serotonergic systems in the pathogenesis of substance use disorders, and the significance of changes in the nucleotide sequences of DRD2, SLC6A3, HTR2A genes in the development of dependence on synthetic cannabinoids with ADHD.

Keywords:

polymorphisms
genes
dependence on psychoactive substances
synthetic cannabinoids
attention deficit hyperactivity disorder

Authors:

Gareeva A.E.

Bashkir State Medical University, Ufa, Russia;
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia

Sharafiev R.R.

Bashkir State Medical University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Nasibullin T.R.

FGBUN «Institut biohimii i genetiki», Ufa

Fakhurtdinova Z.R.

Bashkir State University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

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References:

  1. Groenman AP, Greven CU, van Donkelaar MM, Schellekens A, van Hulzen KJ, Rommelse N, Hartman CA, Hoekstra PJ, Luman M, Franke B, Faraone SV, Oosterlaan J, Buitelaar JK. Dopamine and serotonin genetic risk scores predicting substance and nicotine use in attention deficit. Addict Biol. 2016;21(4):915-923. https://doi.org/10.1111/adb.12230
  2. Carpentier PJ, Arias Vasquez A, Hoogman M, Onnink M, Kan CC, Kooij JJ, Makkinje R, Iskandar S, Kiemeney LA, de Jong CA, Franke B, Buitelaar JK. Shared and unique genetic contributions to attention deficit/hyperactivity disorder and substance use disorders: a pilot study of six candidate genes. Eur Neuropsychopharmacol. 2013;23(6):448-457. https://doi.org/10.1016/j.euroneuro.2012.07.003
  3. Bobzean SA, Denobrega AK, Perrotti LI. Sex differences in the neurobiology of drug addiction. Exp Neurol. 2014;259:64-74. https://doi.org/10.1016/j.expneurol.2014.01.022
  4. Del Campo N, Chamberlain SR, Sahakian BJ, Robbins TW. The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2011;69(12):145-157. https://doi.org/10.1016/j.biopsych.2011.02.036
  5. Johnson BA. Role of the Serotonergic System in the Neurobiology of Alcoholism. CNS Drugs. 2004;18(15):1105-1118. https://doi.org/10.2165/00023210-200418150-00005
  6. Oades RD. 5-The Role of Serotonin in Attention-Deficit Hyperactivity Disorder (ADHD). Handbook of Behavioral Neuroscience. 2010;21:565-584. https://doi.org/10.1016/S1569-7339(10)70101-6
  7. Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature. 2009;461(7265):747-753. https://doi.org/10.1038/nature08494
  8. Kotte A, Faraone SV, Biederman J. Association of genetic risk severity with ADHD clinical characteristics. Am J Med Genet B Neuropsychiatr Genet. 2013;162B(7):718-733. https://doi.org/10.1002/ajmg.b.32171
  9. Davis C, Loxton NJ, Levitan RD, Kaplan AS, Carter JC, Kennedy JL. «Food addiction» and its association with a dopaminergic multilocus genetic profile. Physiol Behav. 2013;118:63-69. https://doi.org/10.1016/j.physbeh.2013.05.014
  10. Asadullin AR. Dynamics of consumption of psychoactive substances in the Republic of Bashkortostan with an in-depth clinical and genetic study of the formation of dependence on substances of the group of synthetic cathinones: Dis... d-ra med. nauk. Ufa. 2018. (In Russ.). https://bekhterev.ru/nauka/dissertacionnyj-sovet/blizhajshie-zashchity/asadullin.php
  11. Akhmetova EA. Study of the prevalence of psychoactive substance use in adolescent schools in the Republic of Bashkortostan with an in-depth socio-psychological and genetic study of a group of consumers of synthetic cannabinoids (spice): Dis... kand. med. nauk. Ufa. 2018. (In Russ.). https://bekhterev.ru/nauka/dissertacionnyj-sovet/blizhajshie-zashchity/akhmetova.php
  12. Jordan CJ. Sensitive periods of substance abuse: early risk for the transition to dependence. Dev Cogn Neurosci. 2017;(25):29-44. https://doi.org/10.1016/j.dcn.2016.10.004
  13. Fattore L. Synthetic cannabinoids — further evidence supporting the relationship between cannabinoids and psychosis. Biol Psychiatry. 79(7):539-548. https://doi.org/10.1016/j.biopsych.2016.02.001
  14. Le Boisselier R, Alexandre J, Lelong‐Boulouard V, Debruyne D. Focus on cannabinoids and synthetic cannabinoids. Clin Pharmacol Ther. 2017;101(2):220-229. https://doi.org/10.1002/cpt.563
  15. Bokhan NA. Clinical typology of psychopathological disorders among users of synthetic cannabinoids (spice). Siberian Bulletin of Psychiatry and Narcology. 2015;4(89):18-23. (In Russ.)
  16. Piomelli D. The molecular logic of endocannabinoid signaling. Nat Rev Neurosci. 2003;4(11):873-884. https://doi.org/10.1038/nrn1247
  17. Mathew CG. The isolation of high molecular weight eucariotic DNA. Methods in molecular biology. Nucleic Acids. 1984;2:31-34. https://doi.org/10.1385/0-89603-064-4:31
  18. Galeyeva AR, Yuryev EB, Valinurova IR, Khusnutdinova EK. Study of the D2-dopamine receptor gene polymorphism in men of different ethnicity with acute alcoholic psychosis. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2000;7:37-40. (In Russ.). https://www.mediasphera.ru/neurol/neur-mn.htm
  19. Galeeva AR, Yuryev EB, Khusnutdinova E.K. Evaluation of VNTR polymorphism in the dopamine transporter gene in men of different ethnicity with acute alcoholic psychosis. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2001;5:43-45. (In Russ.). https://www.fesmu.ru/elib/Article.aspx
  20. Galeyeva AR, Gareeva AE, Yuryev EB, Khusnutdinova EK. VNTR polymorphisms of the serotonin transporter and dopamine transporter genes in male opiate addicts. Molekulyarnaya Biologiya. 2002;36(4):593-598. (In Russ.). https://molecbio.ru/downloads/mbm36/MBM36_4_0593.pdf
  21. Gareeva AE, Yuryev EB, Khusnutdinova EK. An analysis of the associations of NcoI and TaqI polymorphism of the D2 receptor dopamine gene with opium addiction. Zhurnal Nevrologii i Psihiatrii im. S.S. Korsakova. 2004;104(4):46-49. (In Russ.). https://e-library.kazangmu.ru/cgi-bin/irbis64r_12/cgiirbis_64
  22. Yuryev EB, Gareeva AE, Gaysina DA, Khusnutdinova EK. Analysis of DNA polymorphism in tryptophan hydroxylase (TPH), 1B serotonin receptor (5HT1B) and D4 dopamine receptor (DRD4) genes in patients with opium addiction. Meditsinskaya Genetika. 2005;4(6):294-294. (In Russ.). https://webirbis.spsl.nsc.ru/irbis64r_01/cgi/cgiirbis_64
  23. Petri A, Sabin K. Visual statistics in medicine. Translated from English by Leonov V.P. M.: Publishing house GEOTAR-Media; 2003. (In Russ.). https://bookre.org/reader
  24. Vink JM, Posthuma D, Neale MC, Eline Slagboom P, Boomsma DI. Genome-wide linkage scan to identify loci for age at first cigarette in Dutch sibling pairs. Beh Genet. 2006;36(1):100-111. https://doi.org/10.1007/s10519-005-9012-0
  25. Dalley JW, Roiser JP. Dopamine, serotonin and impulsivity. Neuroscience. 2012;215:42-58. https://doi.org/10.1016/j.neuroscience.2012.03.065
  26. Cortese S, Kelly C, Chabernaud C, Proal E, Di Martino A, Milham MP, Castellanos FX. Toward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies. Am J Psychiatry. 2012;169(10):1038-1055. https://doi.org/10.1176/appi.ajp.2012.11101521
  27. Ramboz S, Saudou F, Amara DA, Belzung C, Segu L, Misslin R, Buhot MC, Hen R. 5-HT1B receptor knock out--behavioral consequences. Behav Brain Res. 1996;73(1-2):305-312. https://doi.org/10.1016/0166-4328(96)00119-2
  28. Saudou F, Amara DA, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot MC, Hen R. Enhanced aggressive behavior in mice lacking 5-HT1B receptor. Science. 1994;265(5180):1875-1878. https://doi.org/10.1126/science.8091214
  29. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA. Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice. Psychopharmacology (Berl). 1997;132(2):125-134. https://doi.org/10.1007/s002130050328
  30. Barot SK, Ferguson SM, Neumaier JF. 5-HT(1B) receptors in nucleus accumbens efferents enhance both rewarding and aversive effects of cocaine. Eur J Neurosci. 2007;25(10):3125-3131. https://doi.org/10.1111/j.1460-9568.2007.05568.x
  31. Li J, Wang Y, Qian Q, Wang B, Zhou R. Association of 5-HT(2A) receptor polymorphism and attention deficit hyperactivity disorder in children. Zhonghua Yi Xue Za Zhi. 2002;82(17):1173-1176. https://zhyxzz.yiigle.com/CN112137200217/840189
  32. Hawi Z, Segurado R, Conroy J, Sheehan K, Lowe N, Kirley A, Shields D, Fitzgerald M, Gallagher L, Gill M. Preferential transmission of paternal alleles at risk genes in attention-deficit. Hyperactivity disorder. Am J Hum Genet. 2005;77(6):958-965. https://doi.org/10.1086/498174
  33. Quist JF, Barr CL, Schachar R, Roberts W, Malone M, Tannock R, Basile VS, Beitchman J, Kennedy JL. The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. Mol Psychiatry. 2003;8(1):98-102.
  34. Smoller JW, Biederman J, Arbeitman L, Doyle AE, Fagerness J, Perlis RH, Sklar P, Faraone SV. Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. Biol Psychiatry. 2006;59(5):460-467. https://doi.org/10.1016/j.biopsych.2005.07.017
  35. Guimaraes AP, Schmitz M, Polanczyk GV, Zeni C, Genro J, Roman T, Rohde LA, Hutz MH. Further evidence for the association between attention deficit/hyperactivity disorder and the serotonin receptor 1B gene. J Neural Transm. 2009;116(12):1675-1680. https://doi.org/10.1007/s00702-009-0305-y
  36. Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126(1):51-90. https://doi.org/10.1007/s00439-009-0694-x
  37. Banerjee E, Banerjee D, Chatterjee A, Sinha S, Nandagopal K. Selective maternal inheritance of risk alleles and genetic interaction between serotonin receptor-1B (5-HTR1B) and serotonin transporter (SLC6A4) in ADHD. Psychiatry Research. 2012;200(2-3):1083-1085. https://doi.org/10.1016/j.psychres.2012.04.003
  38. Hou YW, Xiong P, Gu X, Huang X, Wang M, Wu J. Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis. Curr Med Sci. 2018;38(3):538-551. https://doi.org/10.1007/s11596-018-1912-3
  39. Fonseca DJ, Mateus HE, Gálvez JM, Forero DA, Talero-Gutierrez C, Velez-van-Meerbeke A. Lack of association of polymorphisms in six candidate genes in colombian ADHD patients. Ann Neurosci. 2015;22(4):217-221. https://doi.org/10.5214/ans.0972.7531.220405
  40. Sujitha SP, Nair A, Banerjee M, Lakshmanan S, Harshavaradhan S, Gunasekaran S, Gopinathan A. 5-Hydroxytryptamine (serotonin) 2A receptor gene polymorphism is associated with schizophrenia. Indian J Med Res. 2014;140(6):736-743. https://www.researchgate.net/publication/273470351
  41. Elia J, Capasso M, Zaheer Z, Lantieri F, Ambrosini P, Berrettini W, Devoto M, Hakonarson H. Candidate gene analysis in an on-going genome-wide association study of attention-deficit hyperactivity disorder: suggestive association signals in ADRA1A. Psychiatr Genet. 2009;19(3):134-114. https://doi.org/10.1097/YPG.0b013e32832a5043
  42. Reuter M, Kirsch P, Hennig J. Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS). J Neural Transm. (Vienna). 2006;113(7):929-938. https://doi.org/10.1007/s00702-005-0366-5
  43. Zhang L, Chang S, Li Z, Zhang K, Du Y, Ot J, Wang J. ADHD gene: a genetic database for attention deficit hyperactivity disorder. Nucleic Acids Res. 2011;40(1):1003-1009. https://doi.org/10.1093/nar/gkr992
  44. Faraone SV, Spencer TJ, Madras BK, Zhang-James Y, Biederman J. Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a metaanalysis. Mol Psychiatry. 2014;19(8):880-900. https://doi.org/10.1038/mp.2013.126
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