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Gareeva A.E.

Bashkir State Medical University, Ufa, Russia;
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia

Sharafiev R.R.

Bashkir State Medical University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Nasibullin T.R.

FGBUN «Institut biohimii i genetiki», Ufa

Fakhurtdinova Z.R.

Bashkir State University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

The combined effect of genetic factors and attention deficit hyperactivity disorder on the development of dependence on synthetic cannabinoids

Authors:

Gareeva A.E., Sharafiev R.R., Akhmetova E.A., Nasibullin T.R., Fakhurtdinova Z.R., Yuldashev V.L., Asadullin A.R.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2): 15‑21

DOI: 10.17116/jnevro202012002115

Views: 3820

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To cite this article:

Gareeva AE, Sharafiev RR, Akhmetova EA, Nasibullin TR, Fakhurtdinova ZR, Yuldashev VL, Asadullin AR. The combined effect of genetic factors and attention deficit hyperactivity disorder on the development of dependence on synthetic cannabinoids. S.S. Korsakov Journal of Neurology and Psychiatry. 2020;120(2):15‑21. (In Russ.)
https://doi.org/10.17116/jnevro202012002115

 
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Objective. To develop a model of assessment of individual risk of dependence on synthetic cannabinoids based on genetic factors and diagnosis of attention deficit hyperactivity disorder (ADHD). Material and methods. The study included 146 male adolescents using synthetic cannabinoids and 136 healthy people. The genetic study considered the combination of dependence on synthetic cannabinoids and ADHD. Six polymorphisms in the genes of dopaminergic and serotonergic systems were genotyped. Results and conclusion. In general, the results of this work confirm the important role of the dopaminergic and serotonergic systems in the pathogenesis of substance use disorders, and the significance of changes in the nucleotide sequences of DRD2, SLC6A3, HTR2A genes in the development of dependence on synthetic cannabinoids with ADHD.

Keywords:

polymorphisms
genes
dependence on psychoactive substances
synthetic cannabinoids
attention deficit hyperactivity disorder

Authors:

Gareeva A.E.

Bashkir State Medical University, Ufa, Russia;
Institute of Biochemistry and Genetics, Ufa Federal Research Center of the Russian Academy of Sciences, Ufa, Russia

Sharafiev R.R.

Bashkir State Medical University, Ufa, Russia

Akhmetova E.A.

Bashkir State Medical University, Ufa, Russia

Nasibullin T.R.

FGBUN «Institut biohimii i genetiki», Ufa

Fakhurtdinova Z.R.

Bashkir State University, Ufa, Russia

Yuldashev V.L.

Bashkir State Medical University, Ufa, Russia

Asadullin A.R.

Bashkir State Medical University, Ufa, Russia

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