The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode

Prokhorova T.A.

Tereshkina E.B.

Savushkina O.K.

Boksha I.S.

Research Centre of Mental Health

Vorobeva E.A.

Vishnevsky National Medical Research Center for Surgery of the Russia, Moscow, Russia

Omel'chenko M.A.

Pomytkin A.N.

Research Centre of Mental Health

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Burbaeva G.Sh.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode

Authors:

Prokhorova T.A., Tereshkina E.B., Savushkina O.K., Boksha I.S., Vorobeva E.A., Omel'chenko M.A., Pomytkin A.N., Kaleda V.G., Burbaeva G.Sh.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4): 47‑54

DOI: 10.17116/jnevro201911904147

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To cite this article:

Prokhorova TA, Tereshkina EB, Savushkina OK, et al. . The activity of enzymes of glutathione metabolism in blood cells of patients with a high risk of manifestation of endogenous psychoses and patients with the first psychotic episode. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(4):47‑54. (In Russ.)
https://doi.org/10.17116/jnevro201911904147

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Objective. To assess the activity of glutathione reductase (GR) and glutathione-S-transferase (GST) in blood cells of patients at clinical high-risk (HR) state for psychosis, in first-episode patients with schizophrenia and schizoaffective disorder (SD), and control group, and to seek correlations of these biochemical parameters with clinical assessments in patients. Material and methods. The study included male patients at HR (n=21, 16—25 years old), first-episode patients with schizophrenia (F20, n=14, 18—25 years old) and SD (F25, n=20, 16—25 years old), and 12 people of the control group (19—25 years old). Psychometric scales (SOPS, HDRS, and PANSS) and psychopathological methods were employed. GR and GST enzymatic activities were determined spectrophotometrically. Results. The activities of platelet GR and GST in all groups of patients both before and after treatment were lower than in controls (p<0.01). The platelet GST activity was lower in patients at HR compared to patients with schizophrenia before treatment and lower than in patients with SD after treatment (p<0.05), it was higher in patients with schizophrenia than in patients with SD before treatment (p<0.05). Erythrocyte GST activity in patients with HR was lower than in patients with SD after treatment, and in the latter it exceeded that in patients with schizophrenia and controls (p<0.05). Complex and different patterns of changes in the activities of erythrocyte and platelet GR and GST in patients with schizophrenia spectrum disorders, occurring both before the first psychotic episode in the initial stage of disease, and in the first-episode patients, were detected. Conclusion. The activity of glutathione-converting enzymes in endogenous psychoses of the schizophrenic spectrum, including its early stages, can be used as a biomarker for predicting the development of psychosis, the course of disease, and as criteria for evaluation of therapeutic response to antipsychotic treatment.

Keywords:

glutathione reductase

glutathione-S-transferase

platelets

erythrocytes

the first-episode psychosis

high risk for psychosis

Authors:

Prokhorova T.A.

Tereshkina E.B.

Savushkina O.K.

Boksha I.S.

Research Centre of Mental Health

Vorobeva E.A.

Vishnevsky National Medical Research Center for Surgery of the Russia, Moscow, Russia

Omel'chenko M.A.

Pomytkin A.N.

Research Centre of Mental Health

Kaleda V.G.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

SPIN RSCI: 9035-3290
Scopus AuthorID: 56765570100
ResearcherID: K-5466-2013
ORCID: 0000-0002-1209-1443

Burbaeva G.Sh.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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