Effectiveness of the tenoxicam in patients with ankylosing spondylitis

Gaydukova I.Z.; Aparkina A.V.; Khondkaryan E.V.; Rebrov A.P.

doi:https://doi.org/10.17116/jnevro20181182135-39

Gaydukova I.Z.

Mechnikov North-West State Medical University, St. Petersburg, Russia

Aparkina A.V.

Hospital Therapy Department, Saratov Federal State Medical University, Saratov, Russia

Khondkaryan E.V.

Hospital Therapy Department, Saratov Federal State Medical University, Saratov, Russia

Rebrov A.P.

V.I. Razumovskyy Saratov State Medical University, Saratov, Russia

Effectiveness of the tenoxicam in patients with ankylosing spondylitis

Authors:

Gaydukova I.Z., Aparkina A.V., Khondkaryan E.V., Rebrov A.P.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(2): 35‑39

DOI: 10.17116/jnevro20181182135-39

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To cite this article:

Gaydukova IZ, Aparkina AV, Khondkaryan EV, Rebrov AP. Effectiveness of the tenoxicam in patients with ankylosing spondylitis. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(2):35‑39. (In Russ.)
https://doi.org/10.17116/jnevro20181182135-39

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Objective. To study the changes in pain syndrome and its characteristic in patients with ankylosing spondylitis (AS) who received tenoxicam after non-effective treatment with NSAIDs on the «on-demand» basis. Material and methods. Forty patients with AS, who had BASDAI ≥4.0 at baseline and after 52 weeks of NSAIDs on the «on-demand» basis, were randomized into 2 groups: 30 patients were prescribed 20 mg of tenoxicam oraly per day, 10 patients continued previous therapy. The BASDAI, ASDAS indices were calculated in 52 and 56 weeks. Results and conclusion. BASDAI and ASDAS indices decreased in patients treated with tenoxicam, the AS activity in patients with on-demand NSAID intake did not change. The change of the ineffective long-term NSAID intake in the «on-demand» basis to permanent drug intake was associated with a rapid (within 4 weeks) decrease in the clinical activity of ankylosing spondylitis.

Keywords:

ankylosing spondylitis

NSAIDs

on-demand NSAIDs intake

continuous NSAIDs administration

Authors:

Gaydukova I.Z.

Mechnikov North-West State Medical University, St. Petersburg, Russia

Aparkina A.V.

Hospital Therapy Department, Saratov Federal State Medical University, Saratov, Russia

Khondkaryan E.V.

Hospital Therapy Department, Saratov Federal State Medical University, Saratov, Russia

Rebrov A.P.

V.I. Razumovskyy Saratov State Medical University, Saratov, Russia

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References:

Erdes ShF, Badokin VV, Bochkova AG, Bugrova OV, Gaidukova IZ, Godzenko AA, Dubikov AA, Dubinina TV, Ivanova ON, Korotaeva TV, Lapshina SA, Nesmeyanova OB, Nikishina IP, Otteva EN, Raskina TA, Rebrov AP, Rumyantseva OA, Sitalo AV, Smirnov AV. On the terminology of spondyloarthritis. Rheumatology Science and Practice. 2015;53(6):657-660. (In Russ.) https://doi.org/10.14412/1995-4484-2015-657-660
van der Heijde D, Ramiro S, Landewé R, Baraliakos X, Van den Bosch F, Sepriano A, Regel A, Ciurea A, Dagfinrud H, Dougados M, van Gaalen F, Géher P, van der Horst-Bruinsma I, Inman RD, Jongkees M, Kiltz U, Kvien TK, Machado PM, Marzo-Ortega H, Molto A, Navarro-Compàn V, Ozgocmen S, Pimentel-Santos FM, Reveille J, Rudwaleit M, Sieper J, Sampaio-Barros P, Wiek D, Braun J. 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis. Ann Rheum Dis. 2017;76(6):978-991. https://doi.org/10.1136/annrheumdis-2016-210770.
Schoels MM, Braun J, Dougados M, Emery P, Fitzgerald O, Kavanaugh A, Kvien TK, Landewé R, Luger T, Mease P, Olivieri I, Reveille J, Ritchlin C, Rudwaleit M, Sieper J, Smolen JS, Wit Md, van der Heijde D. Treating axial and peripheral spondyloarthritis, including psoriatic arthritis, to target: results of a systematic literature search to support an international treat-to-target recommendation in spondyloarthritis. Ann Rheum Dis. 2014;73(1): 238-242. https://doi.org/10.1136/annrheumdis-2013-203860
Wendling D. Treating to target in axial spondyloarthritis: defining the target and the arrow. Expert Rev Clin Immunol. 2015;11(6):691-693. https://doi.org/10.1586/1744666X.2015.1039514
Baraliakos X, Listing J, Brandt J, Haibel H, Rudwaleit M, Sieper J, Braun J. Radiographic progression in patients with ankylosing spondylitis after 4 yrs of treatment with the anti-TNF-alpha antibody infliximab. Rheumatology (Oxford). 2007;46(9):1450-1453.
Kaplan V, Eroğlu CN. Comparison of the Effects of Daily Single-Dose Use of Flurbiprofen, Diclofenac Sodium, and Tenoxicam on Postoperative Pain, Swelling, and Trismus: A Randomized Double-Blind Study. J Oral Maxillofac Surg. 2016;74(10):1946:1-6. Epub 2016 May 24. https://doi.org/10.1016/j.joms.2016.05.015
Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum. 1984;27(4):361-368.
Garrett S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P, Calin A. A new approach to defining disease status in ankylosing spondylitis: the Bath Ankylosing Spondylitis Disease Activity Index. J Rheumatol. 1994;21(12): 2286-2291.
Brandt J, Listing J, Sieper J, Rudwaleit M, van der Heijde D, Braun J. Development and preselection of criteria for short term improvement after anti-TNF alpha treatment in ankylosing spondylitis. Ann Rheum Dis. 2004;63(11):1438-1444. Epub 2004 Mar 25. https://doi.org/10.1136/ard.2003.016717
Van der Heijde D1, Lie E, Kvien TK, Sieper J, Van den Bosch F, Listing J, Braun J, Landewé R. ASDAS, a highly discriminatory ASAS-endorsed disease activity score in patients with ankylosingspondylitis. Ann Rheum Dis. 2009;68(12):1811-1818. Epub 2008 Dec 5. https://doi.org/10.1136/ard.2008.100826
Machado P, Landewé R, Lie E, Kvien TK, Braun J, Baker D, van der Heijde D. Assessment of SpondyloArthritis international Society Ankylosing Spondylitis Disease Activity Score (ASDAS): defining cut-off values for disease activity states and improvement scores. Ann Rheum Dis. 2011; 70(1):47-53. https://doi.org/10.1136/ard.2010.138594
Calin A, Garrett S, Whitelock H, Kennedy LG, O’Hea J, Mallorie P, Jenkinson T. A new approach to defining functional ability in ankylosing spondylitis: the development of the Bath Ankylosing Spondylitis Functional Index. J Rheumatol. 1994;21(12):2281-2285.
Heuft-Dorenbosch L, Spoorenberg A, van Tubergen A, Landewé R, van ver Tempel H, Mielants H, Dougados M, van der Heijde D. Assessment of enthesitis in ankylosing spondylitis. Ann Rheum Dis. 2003; 62(2):127-132.
Rebrov OYu. Statistical analysis of medical data. The application package Statistica applications. M.: Media Sphere; 2002. (In Russ.)
Amor B, Dougados M, Listrat V, Menkes CJ, Roux H, Benhamou C, Blotman F, Pattin S, Paolaggi JB, Duquesnoy B, et al. Are classification criteria for spondylarthropathy useful as diagnostic criteria? Rev Rhum Engl Ed. 1995;62(1):10-15. PMID:7788318.
ASAS-slide educational kit. http://slides.asas-group.org/app/slides/search?q=&c=17&k=ALL
Der-Yuan Chen, Yi-Ming Chen, Hsin-Hua Chen, Chia-Wei Hsieh, Chi-Chen Lin, Joung-Liang Lan. Increasing levels of circulating Th17 cells and interleukin-17 in rheumatoid arthritis patients with an inadequate response to anti-TNF-α therapy. Arthritis Res Ther. 2011;13(4):R126. Published online 2011 Jul 30. https://doi.org/10.1186/ar3431
Çift H, Özkan FÜ, Tolu S, Şeker A, Mahiroğulları M. Comparison of subacromial tenoxicam and steroid injections in the treatment of impingement syndrome. Eklem Hastalik Cerrahisi. 2015;26(1):16-20. https://doi.org/10.5606/ehc.2015.05.
Erbas M, Simsek T, Kiraz HA, Sahin H, Toman H. Comparison of the effectivity of oral and intra-articular administration of tenoxicam in patients with knee osteoarthritis. Rev Bras Anestesiol. 2015;65(5):333-337. https://doi.org/10.1016/j.bjan.2013.12.003