Ultrastructural changes of myelinated fibers in the brain in continuous and attack-like paranoid schizophrenia

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Kolomeets N.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Vikhreva O.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Zimina I.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Orlovskaia D.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Ultrastructural changes of myelinated fibers in the brain in continuous and attack-like paranoid schizophrenia

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Uranova N.A., Kolomeets N.S., Vikhreva O.V., Zimina I.S., Rakhmanova V.I., Orlovskaia D.D.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2): 104‑109

DOI: 10.17116/jnevro201711721104-109

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Uranova NA, Kolomeets NS, Vikhreva OV, Zimina IS, Rakhmanova VI, Orlovskaia DD. Ultrastructural changes of myelinated fibers in the brain in continuous and attack-like paranoid schizophrenia. S.S. Korsakov Journal of Neurology and Psychiatry. 2017;117(2):104‑109. (In Russ.)
https://doi.org/10.17116/jnevro201711721104-109

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)

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Objective. Previously the authors have reported the ultrastructural pathology of myelinated fibers (MF) in the brain in schizophrenia. The aim of the present study was to compare the effect of disease course on ultrastructural changes of MF. Material and methods. Postmortem electron microscopic morphometric study of MF was performed in the prefrontal cortex, caudate nucleus and hippocampus in 19 cases of paranoid schizophrenia. Fourteen cases of continuous schizophrenia, 5 cases of attack-like schizophrenia and 25 normal matched control cases were studied. The proportion (percentage) of pathological MF was estimated in the prefrontal cortex, layer 5, CA3 area of hippocampus, pyramidal layer, and in the head of the caudate nucleus. Results. The percentage of MF having axonal atrophy and swelling of periaxonal oligodendrocyte process was significantly higher in both continuous and attack-like schizophrenia in all brain structures studied as compared to the control group. In the hippocampus and caudate nucleus, this parameter was increased significantly in attack-like schizophrenia as compared to continuous schizophrenia. In the prefrontal cortex. The percentage of the pathological MF having signs of deformation and destruction of myelin sheaths increased significantly only in continuous schizophrenia as compared to the control group. Conclusion. MF pathology is similar in attack-like and continuous paranoid schizophrenia but differ by the degree of severity of pathological MF. Abnormalities in MF contribute to the disconnectivity between the prefrontal cortex, caudate nucleus and hippocampus.

Keywords:

paranoid continuous schizophrenia

paranoid attack-like schizophrenia

myelinated fibers

ultrastructure

morphometry

prefrontal cortex

caudate nucleus

hippocampus

Authors:

Uranova N.A.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Kolomeets N.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Vikhreva O.V.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Zimina I.S.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

Rakhmanova V.I.

Nauchnyĭ tsentr nevrologii RAMN, Moskva

Orlovskaia D.D.

Nauchnyĭ tsentr psikhicheskogo zdorov'ia RAMN, Moskva

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