The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Bobrov A.E.

Moskovskiĭ nauchno-issledovatel'skiĭ institut psikhiatrii, Moskva

Starostina E.G.

FGUZ "Moskovskiĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut (MONIKI) im. M.F. Vladimirskogo"

Alexandrova M.M.

Pirogov Russian National Research University, Moscow, Russia, Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russia

Mental disorders in patients with acromegaly

Authors:

Bobrov A.E., Starostina E.G., Alexandrova M.M.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9): 18‑23

DOI: 10.17116/jnevro20161169118-23

Read: 1850 times

Download PDF (RU)
Contact the author
Table of contents

MENTAL DISORDERS IN PATIENTS WITH ACROMEGALY
MENTAL DISORDERS IN PATIENTS WITH ACROMEGALY

To cite this article:

Bobrov AE, Starostina EG, Alexandrova MM. Mental disorders in patients with acromegaly. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(9):18‑23. (In Russ.)
https://doi.org/10.17116/jnevro20161169118-23

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Aripiprazole in the treatment of psychiatric diso­rders in childhood. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(10-2):38-47
Abstract:

Objective. To study mental disorders in acromegaly due to somatotropinoma. Material and methods. The study included 115 consecutively recruited patients with acromegaly (95 female and 20 male, aged from 21 to 78 years). Acromegaly was diagnosed by endocrinologists according to current guidelines based on clinical, laboratory data and brain MRI. All patients underwent a clinical psychiatric interview based on ICD-10 criteria. The Mini-Mental State Examination scale and Hypomania-Checklist (HCL-32) were used. Results. Mental disorders were diagnosed in 79.1% of patients. Organic spectrum disorders were found in 46.1%, bipolar spectrum disorders in 35.7%, schizophrenia spectrum disorders in 4.3%. The patients with bipolar spectrum disorders had significantly lower serum insulin-like growth factor 1 (IGF-1) levels compared to patients with organic spectrum disorders (p=0.01). The presence of organic spectrum disorders was associated with older age and number of somatic comorbidities (р=0.0001 and 0.001). Conclusion. The prevalence of bipolar, organic and schizophrenia spectrum disorders in patients with acromegaly exceeds that in the general population. Significantly lower IGF-1 levels in acromegalic patients with bipolar disorders, compared to those with organic disorders, can have some implications to their pathogenesis.

Keywords:

acromegaly
psychoendocrinology
bipolar disorder
organic mental disorder

Authors:

Bobrov A.E.

Moskovskiĭ nauchno-issledovatel'skiĭ institut psikhiatrii, Moskva

Starostina E.G.

FGUZ "Moskovskiĭ nauchno-issledovatel'skiĭ klinicheskiĭ institut (MONIKI) im. M.F. Vladimirskogo"

Alexandrova M.M.

Pirogov Russian National Research University, Moscow, Russia, Vladimirsky Moscow Regional Clinical and Research Institute, Moscow, Russia

Close metadata

References:

  1. Ben-Shlomo A, Sheppard MC, Stephens JM, Pulgar S, Melmed S. Clinical, quality of life, and economic value of acromegaly disease control. Pituitary. 2011;14(3):284-294.  doi: 10.1007/s11102-011-0310-7
  2. Dreval' AV. Jendokrinologija. Rukovodstvo dlja vrachej. M.: GJeOTAR-Media; 2016. (In Russ.).
  3. Kazunori A, Kaoru K, Atushi T, Kuniki E, Koji I, Tohru U, Fumiyoshi K. Mortality in 154 Surgically Treated Patients with Acromegaly-A 10-year Follow-Up Survey. Endocrine Journal. 2003;(50):163-172.  doi: 10.1507/endocrj.50.163
  4. Kauppinen-Mäkelin R, Sane T, Reunanen A, Välimäki MJ, Niskanen L, Markkanen H, Löyttyniemi E, Ebeling T, Jaatinen P, Laine H, Nuutila P, Salmela P, Salmi J, Stenman UH, Viikari J, Voutilainen E. A nationwide survey of mortality in acromegaly. J Clin Endocrinol Metab. 2005;90(7),4081-4086. doi:10.1210/jc.2004-1381
  5. Schneider HJ, Sievers C, Saller B, Wittchen HU, Stalla GK. High prevalence of biochemical acromegaly in primary care patients with elevated IGF-1 levels. Clinical Endocrinology. 2008;69(3):432-435.  doi: 10.1111/j.1365-2265.2008.03221
  6. Orlovskaja DD. Obshhaja harakteristika psihicheskih rasstrojstv pri jendokrinopatijah. V kn. pod red. Snezhnevskogo AV. Rukovodstvo po psihiatrii. T. 2. M.: Medicina; 1983. (In Russ.).
  7. Brambilla F. Psychopathological Aspects of Neuroendocrine Diseases: Possible Parallels with the Psychoendocrine Aspects of Normal Aging. Psychoneuroendocrinology. 1992;17(4):283-291.  doi: 10.1016/0306-4530(92)90035-6
  8. Krechmer Je. Stroenie tela i harakter. M.: Gosudarstvennoe izdatel'stvo medicinskoj literatury; 1930. (In Russ.).
  9. Bleuler M. Endocrinologische Psychiatrie. Cit. po Belkinu AI. Zhurnal nevropatologii i psihiatrii im. S.S. Korsakova. 1957:57(2):271-282. (In Russ.).
  10. Abed RT, Clark J, Elbadawy MH, Cliffe MJ. Psychiatric morbidity in acromegaly. Acta Psychiatrica Scandinavica. 1987;75(6):635-639.  doi:10.1111/j.1600-0447.1987.tb02848.x
  11. Sievers C, Dimopoulou C, Pfister H, Lieb R, Steffin B, Roemmler J. Prevalence of mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients. Clinical Endocrinology. 2009;71:691-701.  doi: 10.1111/j.1365-2265.2009.03555.x
  12. Iglesias P, Bernal C, Díez J. Curious cases: Acromegaly and schizophrenia: an incidental association? Schizophr Bull. 2014;40(4):740-743.  doi: 10.1093/schbul/sbu028
  13. Dobrohotova TA, Faller TO. Psihopatologicheskie sindromy pri opuholjah hiazmal'no-selljarnoj oblasti. V kn.: Opuholi hiazmal'no-selljarnoj oblasti. M.: Medicina; 1976. (In Russ.).
  14. Pantanetti P, Sonino N, Arnaldi G, Boscaro M. Self image and quality of life in acromegaly. Pituitary. 2002;5(1):17-19.  doi: 10.1023/a:1022145116901
  15. Brummelman P, Koerts J, Dullaart RP, van den Berg G, Tucha O, Wolffenbuttel BH, van Beek AP. Effects of previous growth hormone excess and current medical treatment for acromegaly on cognition. European Journal of Clinical Investigation. 2012;42(12):1317-1224. doi: 10.1111/j.1365-2362.2012.02721.x
  16. Dedov II, Molitvoslovova NN, Rozhinskaja LYa, Mel'nichenko GA. Federal'nye klinicheskie rekomendacii po klinike, diagnostike, differencial'noj diagnostike i metodam lechenija akromegalii. Problemy jendokrinologii. 2013;6:4-18. (In Russ.). doi: 10.14341/probl20135964-18
  17. Dreval' AV, Kamynina TS, Nechaeva OA, Pokramovich YuG. Moskovskij oblastnoj registr bol'nyh akromegaliej. Problemy jendokrinologii. 2008;54(4):27-31. (In Russ.).
  18. VOZ. Mezhdunarodnaja klassifikacija boleznej (10-j peresmotr). Klassifikacija psihicheskih i povedencheskih rasstrojstv. Klinicheskie opisanija i ukazanija po diagnostike. Per. na rus. Nullera YuL, Cirkina SYu. SPb.: Overlajd; 1994/ (In Russ.).
  19. Folstein MF, Folstein SE, McHugh PR. «Mini-mental state». A practical method for granding the cognitive state of patients for the clinician. Journal of psychiatric research. 1975;12:189-198.
  20. Mosolov SN, Ushkalova AV, Kostyukova EG, Shafarenko AA, Alfimov PV., Kostjukova AB, Kursakov AA, Obrazcova LV. Validizacija rossijskoj versii oprosnika HCL-32 dlja vyjavlenija pacientov s bipoljarnym affektivnym rasstrojstvom II tipa sredi bol'nyh, nabljudajushhihsja s diagnozom rekurrentnogo depressivnogo jepizoda Social'naja i klinicheskaja psihiatrija. 2015;25(1):21-30.  doi: 10.1016/j.jad.2013.10.029
  21. Angst J, Adolfsson R, Benazzi F, Gamma A, Hantouche E, Meyer T, Skeppar P, Vieta E, Scott J. The HCL-32: Towards a self-assessment tool for hypomanic symptoms in outpatients. Journal of Affective Disorders. 2005;88(2):217-233. (In Russ.). doi: 10.1016/j.jad.2005.05.011
  22. Akiskal HS, Pinto O. The evolving bipolar spectrum. Prototypes I, II, III, and IV. Psychiatr Clin North Am. 1999;22(3):517-534.  doi: 10.1016/s0193-953x(05)70093-9
  23. Rukovodstvo po psihiatrii. Pod red. Snezhnevskogo AV. M.: Medicina; 1983. (In Russ.).
  24. Crum R, Anthony J, Bassett S, Folstein M. Population-Based Norms for the Mini-Mental State Examination by Age and Educational Level. JAMA, 1993;269(18):2386-2391. doi: 10.1001/jama.1993.03500180078038
  25. Bleuler M. Personality changes in pituitary disorders. British Medical Journal. 1951;1(4706):580-581.  doi: 10.1136/bmj.1.4706.580
  26. Celibeev BA. Psihicheskie narushenija pri jendokrinnyh zabolevanijah. M.: Medicina; 1966. (In Russ.).
  27. Krasnushkin EK. O nekotoryh otnoshenijah mezhdu dushevnymi i somaticheskimi zabolevanijami. Nevropatologija i psihiatrija. 1942;1-2:20-32. (In Russ.).
  28. Bobrov AE, Mel'nichenko GA, Pjatnickij NJu, Bondarenko MG. Osobennosti psihicheskih sostojanij u bol'nyh s pervichnoj giperprolaktinemiej. Problemy jendokrinologii. 1995;41(2):22-25. (In Russ.).
  29. Dobrzhanskaja AK. Psihicheskie i nejrofiziologicheskie narushenija pri jendokrinnyh zabolevanijah. M.: Medicina; 1973. (In Russ.).
  30. Jablensky A. Prevalence and incidence of schizophrenia spectrum disorders: implications for prevention. Aust N Z J Psychiatry. 2000;34(suppl):26-34.  doi: 10.1046/j.1440-1614.2000.00770.x
  31. Robins L, Wing J, Wittchen H, Helzer J, Babor T, Burke J, Farmer A, Jablenski A, Pickens R, Regier DA, Sartorius N, Towle L. The Composite International Diagnostic Interview: An Epidemiologic Instrument Suitable for Use in Conjunction With Different Diagnostic Systems and in Different Cultures. Arch Gen Psychiatry. 1988;45(12):1069-1077. doi: 10.1001/archpsyc.1988.01800360017003
  32. Goldney RD, Fisher LJ, Hawthorne G. Depression and the CIDI. British Journal of Psychiatry. 2004;185:518-519.  doi: 10.1192/bjp.185.6.518-a
  33. Benazzi F, Akiskal H. The modified SCID Hypomania Module (SCID-Hba): A detailed systematic phenomenologic probing. Journal of Affective Disorders. 2009;117(3):131-136.  doi: 10.1016/j.jad.2009.06.001
  34. Mcdonald KC, Bulloch AG, Duffy A, Bresee L, Williams JV, Lavorato DH, Patten SB. Prevalence of Bipolar I and II Disorder in Canada. Can J Psychiatry. 2015;60(3):151-156.
  35. Akiskal HS, Mendlowicz MV, Jean-Louis G, Rapaport MH, Kelsoe JR, Gillin JC, Smith TL. TEMPS-A: validation of a short version of a self-rated instrument designed to measure variations in temperament. Journal of Affective Disorders. 2005;85(1-2):45-52.  doi: 10.1016/j.jad.2003.10.012
  36. Liu X, Zhang T, He S, Hong B, Chen Z, Peng D, Wu Y, Wen H, Lin Z, Fang Y, Jiang K. Elevated serum levels of FGF2, NGF and IGF1 in patients with manicepisode of bipolar disorder. Psychiatry Re. 2014;218(1-2):5460. doi: 10.1016/j.psychres.2014.03.042
  37. Kim YK, Na KS, Hwang JA, Yoon HK, Lee HJ, Hahn SW, Lee BH, Jung HY. High insulinlike growth factor1 in patients with bipolar I disorder: a trait marker? J Affect Disord. 2013;151(2):738-743.  doi: 10.1016/j.jad.2013.07.041
  38. Prokudin VN. Pjatiletnij opyt organizacii psihoterapevticheskoj, psihiatricheskoj i narkologicheskoj pomoshhi v somaticheskoj bol'nice. Social'naja i klinicheskaja psihiatrija. 2005;2:73-78. (In Russ.).
  39. Prokudin V, Boyko Y, Kyrov N. The peculiarities of organization consultative liaision psychiatry/psychotherapy in multiprofile general hospital (12-years experience). European Psychiatry. 2010;25(1):510.  doi: 10.1016/S0924-9338(10)70505-8
  40. Dreval' AV, Trigolosova IV, Vinogradova AV, Ilovajskaja IA. Rasprostranennost' saharnogo diabeta sredi bol'nyh akromegaliej. Problemy jendokrinologii. 2012;58(3):9-11.  doi: 10.14341/probl20125839-11 
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.