The use of Pantogam syrup in treating small children’s breath holding spells

Polskaya A.V.

Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

Chutko L.S.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

SPIN RSCI: 8414-1893
Scopus AuthorID: 6507009385
ORCID: 0000-0002-1065-9859

Jakovenko E.V.

Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

The use of Pantogam syrup in treating small children’s breath holding spells

Authors:

Polskaya A.V., Chutko L.S., Jakovenko E.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8): 74‑76

DOI: 10.17116/jnevro20161168174-76

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To cite this article:

Polskaya AV, Chutko LS, Jakovenko EV. The use of Pantogam syrup in treating small children’s breath holding spells. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(8):74‑76. (In Russ.)
https://doi.org/10.17116/jnevro20161168174-76

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The follow-up examination of children with breath-holding spells. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(11-2):76-80

Objective. To study the efficacy of pantogam syrup 10% (hopantenic acid) in the treatment of breath-holding spells (BHS). Material and methods. Sixty children, aged from 2 to 4 years, with BHS were studied. The evaluation of clinical manifestations and anxiety level was performed. Results of neurophysiological examination (long-term video-EEG-monitoring) were analyzed. Children were divided into 2 groups: main, in which the patients received pantogam syrup, and control group, in which only psychological methods were used. Results and Conclusion. The results of the clinical and neurophysiological studies performed after the treatment, showed the clinical improvement in 73.3% of patients of the main group compared with similar data from the children in the control group (16.7%). The anxiety level significantly decreased after the neuroprotective therapy. A comparative analysis of electroencephalographic indicators demonstrated a significant (р<0.05) reduction in the power range of slow rhythms and manifestations of functional immaturity of the brain in patients of the main group. These results give evidence for the high efficacy of pantogam syrup in the treatment of children with BHS.

Keywords:

breath-holding spells

Pantogam-syrup

Authors:

Polskaya A.V.

Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

Chutko L.S.

Institut mozga cheloveka RAN im. N.P. Bekhterevoĭ, Sankt-Peterburg;
Sankt-Peterburgskaia gosudarstvennaia pediatricheskaia meditsinskaia akademiia

SPIN RSCI: 8414-1893
Scopus AuthorID: 6507009385
ORCID: 0000-0002-1065-9859

Jakovenko E.V.

Institute of Human Brain, Russian Academy of Sciences, St. Petersburg, Russia

List of references:

Pal'chik AB, Ponjatishin AE. Nejepilepticheskie paroksizmy u grudnyh detej. M.: MEDprecs-inform; 2015;100-111. (In Russ.).
Korostovcev DD, Guzeva VI, Fomina MJu, Atamanova JeJe, Razumovskij MA. Nejepilepticheskie paroksizmal'nye rasstrojstva u detej. SPb. 2006. (In Russ.).
Silbert P, Gubbay S. Familial cyanotic breath-holding spells. J Pediatr Child Health. 1992;28:3:254-256. doi: 10.1111/j.1440-1754.1992.tb02657.x
DiMario FJJr, Sarfarazi M. Family pedigree analysis of children with severe breath-holding spells. J Pediatr. 1997;130:646-651. doi: 10.1016/S0022-3476(97)70251-8
Emery ES. Status epilepticus secondary to breath-holding and pallid syncopal spells. Neurology. 1990;40:5:859. doi: 10.1212/wnl.40.5.859
Breukels MA, Plötz FB, van Nieuwenhuizen O, J. van Diemen-Steenvoorde AAM. Breath holding spells in a 3-day-old neonate: an unusual early presentation in a family with a history of breath holding spells. Neuropediatrics. 2002;33:1:41-42. doi: 10.1055/s-2002-23591
Goraya JS. Treatment of Cyanotic Breath-Holding Spells With Oral Theophylline in a 10-Year-Old Boy. Journal of Child Neurol. 2015;30:919-921. doi: 10.1177/0883073814540519
Miller BD, Wood BL. Emotions and family factors in childhood asthma: psychobiologic mechanisms and pathways of effect. In: Brown ES. ed. Asthma: Social and psychological factors and psychosomatic syndromes. Adv Psychosom Med Basel, Karger. 2003;24:131-160. doi: 10.1097/01.chi.0000237711.81378.46
DiMario FJJr. Prospective study of children with cyanotic and pallid breath-holding spells. Pediatrics. 2001;107:265-269. doi: 10.1542/peds.107.2.265
Taiwo B, Hamilton AH. Cardiac arrest: a rare complication of pallid syncope? Postgraduate Medical Journal. 1993;69:815:738-739. doi: 10.1136/pgmj.69.815.738
Kuhle S, Tiefenthaler M, Seidl R, Hauser E. Prolonged generalized epileptic seizures triggered by breath-holding spells. Pediatr Neurol. 2000;23(3):271-273. doi: 10.1016/s0887-8994(00)00182-x
Kelly AM, Porter C-BJ, McGoon MD, Espinosa RE, Osborn MJ, Hayes DL. Breath-holding spells associated with significant bradycardia: successful treatment with permanent pacemaker implantation. Pediatrics. 2001;108:3:698-702. doi: 10.1542/peds.108.3.698
Voronina TA. Pantogam i pantogam aktiv. Klinicheskoe primenenie i fundamental'nye issledovanija. M. 2009;11-30. (In Russ.).
Skoromec AA, Skoromec AP, Skoromec TA. Topicheskaja diagnostika zabolevanij nervnoj sistemy. Rukovodstvo dlja vrachej. SPb.: Politehnika; 2009. (In Russ.).

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