The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Farrahova K.I.

Rossijskij natsional'nyj issledovatel'skij meditsinskij universitet im. N.I. Pirogova», Moskva

Karneev A.N.

Chipova D.T.

Berbekov Kabardino-Balkarian State University, Nalchik

Phospholipids metabolism disorders in acute stroke

Authors:

Solov'eva É.Iu., Farrahova K.I., Karneev A.N., Chipova D.T.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(1): 104‑112

DOI: 10.17116/jnevro201611611104-112

Read: 8243 times

Download PDF (RU)
Contact the author
Table of contents

PHOSPHOLIPIDS METABOLISM DISORDERS IN ACUTE STROKE
PHOSPHOLIPIDS METABOLISM DISORDERS IN ACUTE STROKE

To cite this article:

Solov'eva ÉIu, Farrahova KI, Karneev AN, Chipova DT. Phospholipids metabolism disorders in acute stroke. S.S. Korsakov Journal of Neurology and Psychiatry. 2016;116(1):104‑112. (In Russ.)
https://doi.org/10.17116/jnevro201611611104-112

Подписка 2025-2 (S.S. Korsakov Journal of Neurology and Psychiatry)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Mediasphera_Net
Close metadata

The disturbances of cerebral circulation results in the violation of phospholipid metabolism. Activation of lipid peroxidation and protein kinase C and release of intracellular calcium leads to disruption of the homeostasis of phosphatidylcholine. The use of cytidine-5-diphosphocholine, which is used as an intermediate compound in the biosynthesis of phospholipids of the cell membrane, helps to stabilize cell membranes and reduce the formation of free radicals.

Keywords:

brain ischemia
phospholipids
phosphatidylcholine
protein kinase C
free radicals

Authors:

Solov'eva É.Iu.

Kafedra nevrologii FUV GOU VPO RGMU, Moskva

Farrahova K.I.

Rossijskij natsional'nyj issledovatel'skij meditsinskij universitet im. N.I. Pirogova», Moskva

Karneev A.N.

Chipova D.T.

Berbekov Kabardino-Balkarian State University, Nalchik

List of references:

  1. Stakhovskaya L.V. Interv'yu s i.o. direktora NII tserebrovaskulyarnoi patologii i insul'ta, d.m.n., prof. Lyudmiloi Vital'evnoi Stakhovskoi. Zhurnal Nevrologii i psikhiatrii im. S.S. Korsakova. 2012;112:12(2):69-71. 
  2. Gennis R. Biomembrany: molekulyarnaya struktura i funktsii. M.: Mir; 1997.
  3. Neuronal cell signal transduction and second messengers in cerebral ischemia. Ed. Bazan NG. Stuttgart: Wissenschaftliche Verlagsgesellschaft; 1990.
  4. Neurobiology of Essential Fatty Acids. Ed. Bazan NG., Nicolas G, Murphy MG, Toffano G. Springer: USA; 1992.
  5. Siesjö BK, Ekholm A, Asplund B. Transmitter release, ion and water fluxes, and ischemic brain damage. In: Fuxe K, Agnati L, eds. Volume transmission in the brain: novel mechanisms for neural transmission. New York: Raven Press; 1991:539-547.
  6. Bazan NG. Free arachidonic acid and other lipids in the nervous system during early ischemia and after electroshock. Adv Exp Med Biol 1976;72:317-335. doi: 10.1007/978-1-4684-0955-0_26.
  7. Sun G, Su K, Der O, Tang W. Enzymic regulation of arachidonate metabolism in brain membrane phosphoglycerides. Lipids. 1979;14:229-235. doi: 10.1007/bf02533874.
  8. Siesjö BK, Ingvar M, Westerberg E. The influence of bicuculline-induced seizures on free fatty acid concentrations in cerebral cortex, hippocampus and cerebellum. Neurochem J. 1982;39:796-802. doi: 10.1111/j.1471-4159.1982.tb07962.x.
  9. Kontos H. Oxygen radicals in cerebral vascular injury. Circ Res. 1985;57:508-516. doi: 10.1161/01.res.57.4.508
  10. Dávalos A, Alvarez-Sabín J, Castillo J, Díez-Tejedor E, Ferro J, Martínez-Vila E, Serena J, Segura T, Cruz VT, Masjuan J, Cobo E, Secades JJ. Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial). Lancet. 2012;380:349-357. doi: 10.1016/s0140-6736(12)60813-7.
  11. Goracci G, Francescangeli E, Horrocks LA, Porcellati G. The reverse reaction of cholinephosphotransferase in rat brain microsomes, a new pathway for degradation of phosphatidylcholine. Biochim Biophys Acta. 1981;664: 373-379. doi:10.1016/0005-2760(81)90059-x.
  12. Horrocks L, Dorman R, Dabrowiecki Z, Goracci G, Porcellati G. CDPcholine and CDPethanolamine prevent the release of free fatty acids during brain ischemia. Prog Lipid Res. 1982;20:531-534. doi: 10.1016/0163-7827(81)90093-x.
  13. Burgoyne R, Cheek TR, Sullivan AJ. Receptor-activation of phospholipase A2 in cellular signalling. Trends Biochem Sci. 1987;12:332-333. doi:10.1016/0968-0004(87)90155-1.
  14. Nicoletti F, Meek JL, Iadarola MJ, Chuang DM, Roth BL, Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Neurochem J. 1986;46:40-46. doi: 10.1111/j.1471-4159.1986.tb12922.x.
  15. Sladeczek F, Recasens M, Bockaert J. A new mechanism for glutamate receptor action: phosphoinositide hydrolysis. Trends Neurosci. 1988;11: 545-549. doi: 10.1016/0166-2236(88)90183-x.
  16. Braquet P, Touqui L, Shen TS, Vargaftig BB. Perspectives in platelet activating factor research. Pharmacol Rev. 1987;39: 97-145.
  17. Kumar R, Harvey SAK, Kester MK, Hanahan DJ, Olson MS. Production and effects of platelet-activating factor in the rat brain. Biochim Biophys Acta. 1988;963:375-383. doi: 10.1016/0005-2760(88)90304-9.
  18. Snyder F. Biochemistry of platelet-activating factor: a unique class of biologically active phospholipids. Proc Soc Exp Biol Med. 1989;190:125-135. doi: 10.3181/00379727-190-42839.
  19. Edgar A, Strosznajder J, Horrocks L. Activation of ethanolamine phospholipase A2 in brain during ischemia. Neurochem J. 1982;39:1111-1116. doi:10.1111/j.1471-4159.1982.tb11503.x.
  20. Aveldaño M, Bazan NG. Rapid production of diacylglycerols enriched in arachidonate and stearate during early brain ischemia. Neurochem J. 1975;25:919-920. doi: 10.1111/j.1471-4159.1975.tb04432.x.
  21. Banschbach MW, Geison RL. Post-mortem increase in rat cerebral hemisphere diglyceride pool size. Neurochem J. 1974;23:875-877. doi: 10.1111/j.1471-4159.1974.tb04418.x.
  22. Abe K, Yuki S, Kogure K. Strong attenuation of ischemic and postischemic brain edema in rats by a novel free radical scavenger. Stroke. 1988;19:480-485. doi: 10.1161/01.str.19.4.480.
  23. Ikeda M, Yoshida S, Busto R, Santiso M, Ginsberg MD. Polyphosphoinositides as a probable source of brain free fatty acids accumulated at the onset of ischemia. Neurochem J. 1986;47:123-132. doi: 10.1111/j.1471-4159.1986.tb02839.x.
  24. Abe K, Kogure K, Yamamoto H, Imazawa M, Miyamoto K. Mechanism of arachidonic acid liberation during ischemia in gerbil cerebral cortex. Neurochem J. 1987;48:503-509. doi: 10.1111/j.1471-4159.1987.tb04121.x.
  25. Pediconi M, Rodriguez de Turco E. Free fatty acid content and release kinetics as manifestations of cerebral lateralization in mouse brain. Neurochem J. 1984;43:1-7. doi: 10.1111/j.1471-4159.1984.tb06671.x.
  26. Chan P, Fishman R. Transient formation of superoxide radicals in polyunsaturated fatty acid-induced brain swelling. Neurochem J. 1980;35:1004-1007. doi:10.1111/j.1471-4159.1980.tb07100.x.
  27. Silver IA, Erecinska M. Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. Gen Physiol J. 1990;95:837-866. doi: 10.1085/jgp.95.5.837
  28. Rehncrona S, Siesjö BK, Smith DS. Reversible ischemia of the brain: Biochemical factors influencing restitution. Acta Physiol Scand Suppl. 1980;492:135-140. doi: 10.1085/jgp.95.5.837.
  29. Rehncrona S, Westerberg E, Akesson B, Siesjö BK. Brain cortical fatty acids and phospholipids during and following complete and severe incomplete ischemia. Neurochem J. 1982;38:84-93. doi: 10.1111/j.1471-4159.1982.tb10857.x.
  30. Yoshida S, Harik SK, Busto R, Santiso M, Martinez E, Ginsberg MD. Free fatty acids and energy metabolites in ischemic cerebral cortex with noradrenaline depletion. Neurochem J. 1984;42:711-717. doi:10.1111/j.1471-4159.1984.tb02741.x.
  31. Yoshida S, Inoh S, Asano T, Kubota M, Shimasaki H, Uera N. Effect of transient ischemia on free fatty acids and phospholipids in the gerbil brain. Neurosurg J. 1980;53:323-331. doi: 10.3171/jns.1980.53.3.0323.
  32. Gaudet R, Alam I, Levine L. Accumulation of cyclooxygenase products of arachidonic acid metabolism in gerbil brain during reperfusion after bilateral common carotid artery occlusion. Neurochem J. 1980;35:653-658. doi: 10.1111/j.1471-4159.1980.tb03704.x.
  33. Moskowitz M, Kiwak K, Heikimian K, Levine L. Synthesis of compounds with properties of leukotrienes C4 and D4 in gerbil brains after ischemia and reperfusion. Science. 1984;224:886-889. doi: 10.1126/science.6719118.
  34. Gilboe DD, Kintner D, Fitzpatrick JH, Emoto SE, Esanu A, Braquet PG, Bazan NG. Recovery of postischemic brain metabolism and function following treatment with a free radical scavenger and platelet-activating factor antagonists. Neurochem J. 1991;56:311-319. doi: 10.1111/j.1471-4159.1991.tb02597.x.
  35. Lindsberg PJ, Yue T-L, Frerichs KU, Hallenbeck JM, Feuerstein G. Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits. Stroke. 1990;21:1452-1457. doi: 10.1161/01.str.21.10.1452.
  36. Siesjö BK. Hypoglycemia, brain metabolism, and brain damage. Diabetes Metab Rev. 1988;4(2):113-144. doi:10.1161/01.str.21.10.1452.
  37. Choi DW. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1988;1:623-634. doi: 10.1016/0896-6273(88)90162-6.
  38. Siesjö BK. Mechanisms of ischemic brain damage. Crit Care Med. 1988;16:954-963. doi: 10.1097/00003246-198810000-00006.
  39. Siesjö BK. Calcium, excitotoxins, and brain damage. News in Physiological Science. 1990;5:120-125. 
  40. Orrenius S, McConkey D, Jones D, Nicotera P. Ca2+-activated mechanisms in toxicity and programmed cell death. ISI Atlas Sci Pharmacology. 1988;2:319-324. doi: 10.1016/0378-4274(92)90208-2.
  41. Kirino T. Delayed neuronal death in the gerbil hippocampus following transient ischemia. Brain Res. 1982;239:57-69. doi: 10.1007/bf00695577.
  42. Pulsinelli WA, Brierley JB, Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol. 1982;11:491-498. doi: 10.1002/ana.410110509.
  43. Deshpande JK, Siesjö BK, Wieloch T. Calcium accumulation and neuronal damage in the rat hippocampus following cerebral ischemia. Cereb Blood Flow Metab J. 1987;7:89-95. doi: 10.1038/jcbfm.1987.13.
  44. Manev H, Costa E, Wroblewski J, Guidotti A. Abusive stimulation of excitatory amino acid receptors: a strategy to limit neurotoxicity. FASEB J. 1990;4:2789-2797.
  45. Manev H, Favaron M, Guidotti A, Costa E. Delayed increase of Ca2+ influx elicited by glutamate: Role in neuronal death. Mol Pharmacol. 1989;36:106-112.
  46. Demopoulos HB, Flamm ES, Seligman ML, Power R, Pietronigro DD, Ransohoff J. Molecular pathology of lipids in CNS membranes. In: Jobsis FF, eds. Oxygen and physiological function Dallas: Professional Information Library; 1977:491-508.
  47. Halliwell B. Superoxide, iron, vascular endothelium and reperfusion injury. Free Radic Res Commun. 1989;5:315-318. doi: 10.3109/10715768909073413.
  48. Martz D, Rayos G, Schielke GP, Betz AL. Allopurinol and dimethylthiourea reduce brain infarction following middle cerebral artery occlusion in the rat. Stroke. 1989;20:488-494. doi: 10.1161/01.str.20.4.488.
  49. Patt A, Harken AH, Burton LK, Rodell TC, Piermattei D, Schorr WJ, Parker NB, Berger EM, Horesh IR, Terada LS, Linas SL, Cheronis JC, Repine JE. Xanthine oxidase-derived hydrogen peroxide contributes to ischemia reperfusion-induced edema in gerbil brains. Clin Invest J. 1988;81:1556-1562. doi: 10.1172/jci113488.
  50. Siesjö BK, Agardh CD, Bengtsson F. Free radicals and brain damage. Cerebrovasc Brain Metab Rev. 1989;1:165-211. 
  51. Del Maestro RF, Thaw HH, Bjork J, Planker M, Arfors KE. Free radicals as mediators of tissue injury. Acta Physiol Scand Suppl. 1980;492: 43-57.
  52. Siesjö BK. Cell damage in the brain: A speculative synthesis. Cereb Blood Flow Metab J. 1981;1:155-185. doi: 10.1038/jcbfm.1981.18.
  53. Floyd R. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J. 1990;4:2587-2597.
  54. Koide T, Asano T, Matsushita H, Takakura K. Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels. Neurochem J. 1986;46:235-242. doi: 10.1111/j.1471-4159.1986.tb12952.x.
  55. Koide T, Gotoh O, Asano T, Takakura K. Alterations of the eicosanoid synthetic capacity of rat brain microvessels following ischemia: Relevance to ischemic brain edema. Neurochem J. 1985;44:85-93. doi:10.1111/j.1471-4159.1985.tb07116.x.
  56. Chan P, Fishman R. The role of arachidonic acid in vasogenic brain edema. Fed Proc. 1984;43:210-213.
  57. Freeman BA, Crapo JD. Biology of disease. Free radicals and tissue injury. Lab Invest. 1982;47:412-422. 
  58. Kontos HA, Wei EP, Povlishock JT, Dietrich WL, Majiera CM, Ellis EF. Cerebral arteriolar damage by arachidonic acid and prostaglandin G2. Science. 1980;209:1242-1245. doi: 10.1126/science.7403881.
  59. Agut J, Font E, Sacristn A, Ortiz JA. Radioactivity incorporation into different cerebral phospholipids after oral administration of 14C methyl CDP-choline. Arzneimittelforschung 1983;33:1048-1050.
  60. D’Orlando KJ, Sandage BW Jr. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurol Res. 1995;17:281-284. doi:10.1046/j.0022-3042.2001.00697.x.
  61. Rao AM, Hatcher JF, Dempsey RJ. Does CDP-choline modulate phospholipase activities after transient forebrain ischemia? Brain Res. 2001;893(1-2):268-272. doi:10.1016/s0006-8993(00)03280-7.
  62. Adibhatla RM, Hatcher JF. Citicoline decreases phospholipase A2 stimulation and hydroxyl radical generation in transient cerebral ischemia. Neurosci ResJ. 2003;73:308-315. doi: 10.1002/jnr.10672.
  63. Zweifler RM. Membrane stabilizer: citicoline. Curr Med Res Opin. 2002;18(2):14-17. doi: 10.1185/030079902125000679.
  64. Lozano Fernandez R. Efficacy and safety of oral CDP-choline. Drug surveillance study in 2817 cases. Arzneimittelforsch. 1983;33:107Z-1080.

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.