Innate and adaptive immunity in children with psychotic forms of autism-spectrum disorders

Klyushnik T.P.; Androsova L.V.; Simashkova N.V.; Zozulya S.A.; Otman I.N.; Koval'-Zaĭtsev A.A.

doi:https://doi.org/

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Androsova L.V.

Scientific center of mental health, Moscow, Russia

Simashkova N.V.

Scientific center of mental health, Moscow, Russia

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Otman I.N.

Scientific center of mental health, Moscow, Russia

Koval'-Zaĭtsev A.A.

Innate and adaptive immunity in children with psychotic forms of autism-spectrum disorders

Authors:

Klyushnik T.P., Androsova L.V., Simashkova N.V., Zozulya S.A., Otman I.N., Koval'-Zaĭtsev A.A.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(8): 41‑45

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Klyushnik TP, Androsova LV, Simashkova NV, Zozulya SA, Otman IN, Koval'-Zaĭtsev AA. Innate and adaptive immunity in children with psychotic forms of autism-spectrum disorders. S.S. Korsakov Journal of Neurology and Psychiatry. 2011;111(8):41‑45. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Leukocyte elastase (LE) activity, functional activity of alpha1-proteinase inhibitor, C-reactive protein, autoantibodies to nerve growth factor and to basic myelin protein have been studied in the blood serum of children with psychotic forms of autistic disorders - children psychosis (F84.02) and atypical children psychosis (F84.11). The activation of innate immunity (the increase in LE activity and acute phase proteins) was seen in children psychosis. The more severe mental disturbances, that are characteristic of endogenous atypical children psychosis, were accompanied by the activation of both innate and adaptive immunity ( the increase of the level of autoantibodies to neuroantigenes in the peripheral blood). Correlations between immunological and clinical parameters suggest the involvement of innate and adaptive immunity in the formation of autistic and cognitive disorders in children.

Keywords:

innate and adaptive immunity

autoantibodies

leukocyte elastase

children autism

Authors:

Klyushnik T.P.

Scientific center of mental health, Moscow, Russia

Androsova L.V.

Scientific center of mental health, Moscow, Russia

Simashkova N.V.

Scientific center of mental health, Moscow, Russia

Zozulya S.A.

Scientific center of mental health, Moscow, Russia

Otman I.N.

Scientific center of mental health, Moscow, Russia

Koval'-Zaĭtsev A.A.

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