Pathogenesis and new strategy in treatment of neuronal conductivity impairments in compression-ischemic neuropathies: a clinical and experimental study

Zhivolupov C.A.; Shapkova E.Iu.; Samartsev I.N.; Fedorov K.V.

doi:https://doi.org/

Zhivolupov C.A.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Shapkova E.Iu.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Samartsev I.N.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Fedorov K.V.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Pathogenesis and new strategy in treatment of neuronal conductivity impairments in compression-ischemic neuropathies: a clinical and experimental study

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Zhivolupov C.A., Shapkova E.Iu., Samartsev I.N., Fedorov K.V.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(8): 41‑50

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Zhivolupov CA, Shapkova EIu, Samartsev IN, Fedorov KV. Pathogenesis and new strategy in treatment of neuronal conductivity impairments in compression-ischemic neuropathies: a clinical and experimental study. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(8):41‑50. (In Russ.)

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова (S.S. Korsakov Journal of Neurology and Psychiatry)

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Abstract:

Compression-ischemic neuropathies remain one of the most actual problems of contemporary neurology due to the prevalence and commonly poor outcome. In the present work, we studied pathogenetic mechanisms of the formation and restoration of neural conductivity in the compression-ischemic model in rabbits and analyzed some features of therapeutic efficacy of the anticholinesterase drug neuromidin in clinical treatment of compression-ischemic neuropathies. We observed a generalized reaction of the nervous system to the acute limb compression in experimental animals. The ability of neuromidin to improve the central conductivity has been clearly shown. The results obtained allow recommending neuromidin in the treatment of patients with compression-ischemic neuropathies owing to its central and peripheral effects.

Keywords:

compression-ischemic neuropathy

conductivity

diaschisis

neuromidin

Authors:

Zhivolupov C.A.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii, Sankt-Peterburg

Shapkova E.Iu.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Samartsev I.N.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

Fedorov K.V.

Kafedra nervnykh bolezneĭ Voenno-meditsinskoĭ akademii im. S.M. Kirova, Sankt-Peterburg

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