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Volchegorskiĭ I.A.

Kafedra farmakologii Iuzhno-Ural'skogo gosudarstvennogo meditsinskogo universiteta Minzdrava Rossii, Cheliabinsk, Rossiia

Mester K.M.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia, Cheliabinskaia oblastnaia klinicheskaia bol'nitsa

Effects of 3-hydroxypiridine and succinic acid derivates on the dynamics of vertebral/neurologic symptoms after the surgical treatment of disk herniations

Authors:

Volchegorskiĭ I.A., Mester K.M.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(3): 19‑24

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EFFECTS OF 3-HYDROXYPIRIDINE AND SUCCINIC ACID DERIVATES ON THE DYNAMICS OF VERTEBRAL/NEUROLOGIC SYMPTOMS AFTER THE SURGICAL TREATMENT OF DISK HERNIATIONS
EFFECTS OF 3-HYDROXYPIRIDINE AND SUCCINIC ACID DERIVATES ON THE DYNAMICS OF VERTEBRAL/NEUROLOGIC SYMPTOMS AFTER THE SURGICAL TREATMENT OF DISK HERNIATIONS

To cite this article:

Volchegorskiĭ IA, Mester KM. Effects of 3-hydroxypiridine and succinic acid derivates on the dynamics of vertebral/neurologic symptoms after the surgical treatment of disk herniations. S.S. Korsakov Journal of Neurology and Psychiatry. 2010;110(3):19‑24. (In Russ.)

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A study of 3-hydroxypiridine and succinic acid derivates (emoxipin, reamberin and mexidol) effects on the 14 week dynamics of vertebral/neurologic symptoms was performed in 136 patients after the surgical treatment of disk herniations. Data obtained demonstrated the reduction of severity of neurodystrophic and radicular syndromes without significant changes in dorsalgia, psychological maladaptation (PM) and disability scores (DS) during 3,5 months in patients treated with emoxipin (150 mg i.v., daily) for two weeks after the microdiscectomy. The two-week administration of reamberin (400 mg i.v., daily) led to the early attenuation of neuropathic pain. The reduction of sings of radicular compression and DS measured with the Roland-Morris questionnaire were delayed for 3 months. Mexidol (300 mg i.v., once a day during two weeks) demonstrated the highest efficacy. This drug attenuated radicular and neurodystrophic syndromes, nociceptive and neuropathic pain, reduced PM and DS measured with both the Roland-Morris and the Oswestry questionnaires during 14 weeks after the surgery.

Keywords:

3-hydroxypiridine and succinic acid derivates
microdiscectomy
vertebral/neurologic symptoms
psychological maladaptation
disability

Authors:

Volchegorskiĭ I.A.

Kafedra farmakologii Iuzhno-Ural'skogo gosudarstvennogo meditsinskogo universiteta Minzdrava Rossii, Cheliabinsk, Rossiia

Mester K.M.

Cheliabinskaia gosudarstvennaia meditsinskaia akademiia, Cheliabinskaia oblastnaia klinicheskaia bol'nitsa

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