Objective. To establish the features of the manifestations of psychovegetative disorders in children and adolescents throughout a long follow-up period. Material and methods. In the pediatric hospital, 102 patients with functional somatic/vegetative disorders with the follow-up from 3 to 17 years were examined. The study used clinical-psychopathological, clinical-follow-up, cohort-dynamic methods. Results and conclusion. Functional vegetative-somatic pathology in children and adolescents proceeds in the form of a psycho-vegetative syndrome. At the manifestation stage in preschool childhood, the psychopathological component is «masked» in nature and later becomes more complex in the clinical picture. In adolescence, the vegetative-somatic symptoms are smoothed out, while the psychopathological component determines the clinical picture with the subsequent possible «normalization» of the condition. The use of psychopharmacological therapy allows treatment of psychopathological disorders and control of vegetative-somatic symptoms.