Objective. Analysis of the dynamics of epidemiological indicators of multiple sclerosis (MS) in the Altai region of the Russian Federation for the period from 2009 to 2017. Material and methods. A comparative analysis of the prevalence, incidence and main clinical characteristics of MS in the Altai region was carried out based on the data of patients with MS from 2009 (1001 patients) to 2017 (1322 patients). Results and conclusion. The prevalence of MS increased from 41.2 to 56.3 per 100 000. The higher prevalence of the disease in cities compared to villages (by 1.8 times) and the ratio of women and men about 2 0 have not changed. About 2% of patients have a family history of MS. The average age of MS onset did not change significantly during the period analyzed (28.5±9.9 years in 2017). The remitting type of the disease is the most common (73%). The incidence of MS was 1.1±0.3 and 2.6±0.5 cases per 100 000 in 1998—2009 and 2010—2017, respectively. Patients with pediatric MS make up 6.5% of all patients with MS. The clinical features of MS onset before the age of 18 compared to the onset at a later age are the lower frequency of motor disorders, pelvic organ dysfunction (no cases were detected), general brain symptoms detectability (10.5%). Conclusion. The population of the Altai region is at high risk of MS. Monitoring and analysis of the dynamics of clinical and epidemiological characteristics of MS are rational for the planning of medical care for patients with MS.