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Druk I.V.

Omsk State Medical University, Omsk, Russia

Drokina O.V.

Omsk State Medical University, Omsk, Russia

Smyalovsky D.V.

Dmitrovskiy City Hospital, Dmitrov, Russia

Smialovskiĭ V.

Kafedra nevrologii poslediplomnogo obrazovaniia Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii, Omsk

Shylova M.A.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Korsakov M.V.

Regional Clinical Hospital, Omsk, Russia

Goltyapin V.V.

S.L. Sobolev Institute of Mathematics, Siberian Branch, Russian Academy of Sciences, Omsk, Russia

Dissection of the internal carotid artery in a patient with connective tissue dysplasia having risk variants of several candidate genes

Authors:

Druk I.V., Drokina O.V., Smyalovsky D.V., Smialovskiĭ V., Shylova M.A., Korsakov M.V., Goltyapin V.V.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12‑2): 5‑12

DOI: 10.17116/jnevro20191191225

Read: 16742 times

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Table of contents

DISSECTION OF THE INTERNAL CAROTID ARTERY IN A PATIENT WITH CONNECTIVE TISSUE DYSPLASIA HAVING RISK VARIANTS OF SEVERAL CANDIDATE GENES
DISSECTION OF THE INTERNAL CAROTID ARTERY IN A PATIENT WITH CONNECTIVE TISSUE DYSPLASIA HAVING RISK VARIANTS OF SEVERAL CANDIDATE GENES

To cite this article:

Druk IV, Drokina OV, Smyalovsky DV, Smialovskiĭ V, Shylova MA, Korsakov MV, Goltyapin VV. Dissection of the internal carotid artery in a patient with connective tissue dysplasia having risk variants of several candidate genes. S.S. Korsakov Journal of Neurology and Psychiatry. 2019;119(12‑2):5‑12. (In Russ.)
https://doi.org/10.17116/jnevro20191191225

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))
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Abstract:

Spontaneous dissection of the vessels of the neck is one of the main causes of ischemic stroke in young patients under 45 years of age. According to morphological studies, dissection of the vessels of the neck can be based on dysplastic changes in the arterial wall in arteriopathies, Marfan syndrome, Ehlers—Danlos syndrome, undifferentiated connective tissue dysplasia. The article presents a case of spontaneous dissection of the internal carotid artery in a 30-year-old patient with clinical manifestations of undifferentiated connective tissue dysplasia and carriage of homozygous variants of candidate genes: 4G/4G of the PAI-1 (–675, 4G/5G), T/T of the MTHFR C677T, 5A/5A of the MMP-3 (–1171 5A/6A) and A/A of the MMP-9 (8202A/G).

Keywords:

dissection of the internal carotid artery
connective tissue dysplasia
PAI-1
MTHFR
MTRR
MMP-3
MMP-9

Authors:

Druk I.V.

Omsk State Medical University, Omsk, Russia

Drokina O.V.

Omsk State Medical University, Omsk, Russia

Smyalovsky D.V.

Dmitrovskiy City Hospital, Dmitrov, Russia

Smialovskiĭ V.

Kafedra nevrologii poslediplomnogo obrazovaniia Omskoĭ gosudarstvennoĭ meditsinskoĭ akademii, Omsk

Shylova M.A.

Sechenov’s First Moscow State Medical University, Moscow, Russia

Korsakov M.V.

Regional Clinical Hospital, Omsk, Russia

Goltyapin V.V.

S.L. Sobolev Institute of Mathematics, Siberian Branch, Russian Academy of Sciences, Omsk, Russia

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