The addition of memantine to galantamine increases treatment efficacy in patients with moderate dementia with Lewy bodies

Vasenina E.E.; Gan'kina O.A.; Levin O.S.

doi:https://doi.org/10.17116/jnevro201811806232

Vasenina E.E.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Gan'kina O.A.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

SPIN RSCI: 5342-1373
Scopus AuthorID: 57147160800
ORCID: 0000-0003-3872-5923

The addition of memantine to galantamine increases treatment efficacy in patients with moderate dementia with Lewy bodies

Authors:

Vasenina E.E., Gan'kina O.A., Levin O.S.

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Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2): 32‑36

DOI: 10.17116/jnevro201811806232

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To cite this article:

Vasenina EE, Gan'kina OA, Levin OS. The addition of memantine to galantamine increases treatment efficacy in patients with moderate dementia with Lewy bodies. S.S. Korsakov Journal of Neurology and Psychiatry. 2018;118(6‑2):32‑36. (In Russ.)
https://doi.org/10.17116/jnevro201811806232

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

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Abstract:

Dementia with Lewy bodies (DLB) is the most frequent cause of dementia in the elderly. Both open and few placebo-controlled studies have demonstrated the efficacy of monotherapy with cholinesterase inhibitors (CI) and memantine in the treatment of these patients. However the efficacy and safety of combined therapy with CI and memantine are poorly studied. Objective. To assess the efficacy of modern antidementia drugs (memantine and galantamine). Material and methods. Thirty-eight patients with DLB were studied. Monotherapy with galantamine in the dose of 16 mg/day was used during the first 6 months in according with current therapeutic recommendations. Then 19 patients who responded to treatment received in addition memantine in the dose of 20 mg/day. Patients’ state was assessed using a battery of scales and tests. Results and conclusion. The combination of memantine and galantamine significantly improved attention, memory, speech functions and behavior. Therefore, the early treatment with the combination of CI and memantine may be effective in treatment of DLB.

Keywords:

dementia with Lewy bodies

memantine

galantamine

cholinesterase inhibitors

Authors:

Vasenina E.E.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Gan'kina O.A.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia, Moskva

Levin O.S.

Rossiĭskaia meditsinskaia akademiia poslediplomnogo obrazovaniia

SPIN RSCI: 5342-1373
Scopus AuthorID: 57147160800
ORCID: 0000-0003-3872-5923

Close metadata

References:

Levin OS, Anikin MA, Vasenina EE. Cognitive and neuropsychiatric disorders in extrapyramidal diseases. Neurology, Neuropsychiatry, Psychosomatics. 2012;4(2):22-30. (In Russ.) https://doi.org/10.14412/2074-2711-2012-2505
Levin OS, Vasenina EE, Anikina MA, Makotrova TA. Dementia with Lewy bodies. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2012;112(10-2):3-12. (In Russ.)
McKeith I, Fairbairn A, Perry, R.. Clinical Diagnostic Criteria for Lewy Body Dementia. Dementia and Geriatric Cognitive Disorders. 1992;3(4):251-252. https://doi.org/10.1159/000107025
Halliday G. Identifying the dynamics of lewy body formation in lewy body diseases. Alzheimer’s & Dementia. 2014;10(4):242. https://doi.org/10.1016/j.jalz.2014.04.367
Levin O, Batukaeva L, Smolentseva I, Amosova N. Efficacy and safety of memantine in Lewy body dementia. Neurosci Behav Physi. 2009;39(6):597-604. https://doi.org/10.1007/s11055-009-9167-x
Lang A, Perry R, McKeith I, Perry E. Dementia with Lewy bodies. Can J Neurol Sci. 1997;24(04):365. https://doi.org/10.1017/s0317167100033151
Kosaka K. Diffuse lewy body disease in Japan. Journal of Neurology. 1990;237(3):197-204. https://doi.org/10.1007/bf00314594
McKeith I, Dickson D, Lowe J, Emre M, O’Brien J, Feldman H, Cummings J, Duda J, Lippa C, Perry E, Aarsland D, Arai H, Ballard, C, Boeve B, Burn D, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz C, Gomez-Tortosa E, Halliday G, Hansen L, Hardy J, Iwatsubo T, Kalaria R, Kaufer D, Kenny R, Korczyn A, Kosaka K, Lee V, Lees A, Litvan I, Londos E, Lopez O, Minoshima S, Mizuno Y, Molina J, Mukaetova-Ladinska E, Pasquier F, Perry R, Schulz J, Trojanowski J, Yamada M. Diagnosis and management of dementia with Lewy bodies: Third report of the DLB consortium. Neurology. 2005;65(12):1863-1872. https://doi.org/10.1212/01.wnl.0000187889.17253.b1
Gomez-Tortosa E, Newell K, Irizarry M, Albert M, Growdon J, Hyman B.. Clinical and quantitative pathologic correlates of dementia with Lewy bodies. Neurology. 1999;53(6):1284-1284. https://doi.org/10.1212/wnl.53.6.1284
Levin OS. Reminyl efficacy in dementia with Levi bodies. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2005;105(10):15-21. (In Russ.)
Edwards K, Royall D, Hershey L, Lichter D, Hake A, Farlow M, Pasquier F, Johnson S.. Efficacy and Safety of Galantamine in Patients with Dementia with Lewy Bodies: A 24-Week Open-Label Study. Dementia and Geriatric Cognitive Disorders. 2007;23(6):401-405. https://doi.org/10.1159/000101512
Grace J, Daniel S, Stevens T, Shankar K, Walker Z, Byrne E, Butler S, Wilkinson D, Woolford J, Waite J, McKeith I. Long-Term Use of Rivastigmine in Patients With Dementia With Lewy Bodies: An Open-Label Trial. Int Psychogeriatr. 2001;13(2):199-205. https://doi.org/10.1017/s104161020100758x
Maclean L, Collins C, Byrne E. Dementia With Lewy Bodies Treated With Rivastigmine: Effects on Cognition, Neuropsychiatric Symptoms, and Sleep. Int Psychogeriatr. 2001;13(3):277-288. https://doi.org/10.1017/s1041610201007670
McKeith I, Del Ser T, Spano P, Emre M, Wesnes K, Anand R, Cicin-Sain A, Ferrara R, Spiegel R. Efficacy of rivastigmine in dementia with Lewy bodies: a randomised, double-blind, placebo-controlled international study. The Lancet. 2000;356(9247):2031-2036. https://doi.org/10.1016/s0140-6736(00)03399-7
Samuel W, Caligiuri M, Galasko D, Lacro J, Marini M, McClure F, Warren K, Jeste D.. Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: a preliminary study. Int J Geriat Psychiatry. 2000;15(9):794-802.
Wesnes K, McKeith I, Ferrara R, Emre M, Del Ser T, Spano P, Cicin-Sain A, Anand R, Spiegel R. Effects of Rivastigmine on Cognitive Function in Dementia with Lewy Bodies: A Randomised Placebo-Controlled International Study Using the Cognitive Drug Research Computerised Assessment System. Dementia and Geriatric Cognitive Disorders. 2002;13(3):183-192. https://doi.org/10.1159/000048651
Lanctot K, Herrmann N. Donepezil for behavioural disorders associated with Lewy bodies: a case series. Int J Geriat Psychiatry. 2000;15(4):338-345.
Folstein M, Folstein S,. McHugh P. Mini-mental state: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research. 1975;12:189-198.
Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges J. The Addenbrooke’s Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriat Psychiatry. 2006;21(11):1078-1085. https://doi.org/10.1002/gps.1610
Levin OS, Lavrov A, Lyashenko EA, Vasenina EE, Trusova NA, Datieva VK, Makotrova TA, Pilipenko AYu. Validation of the Russian version of the modified Addenbrooke’s cognitive examination for Alzheimer’s disease diagnosis. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015;115(6-2):36-39. (In Russ.) https://doi.org/10.17116/jnevro20151156236-39
Shulman K, Pushkar Gold D, Cohen C, Zucchero C. Clock-drawing and dementia in the community: A longitudinal study. Int J Geriat Psychiatry. 1993;8(6):487-496. https://doi.org/10.1002/gps.930080606
Lehfeld H, Rudinger G, Rietz C, Heinrich C, Wied V, Fornazzari L, Pittas J, Hindmarch I, Erzigkeit H. Evidence of the Cross-Cultural Stability of the Factor Structure of the SKT Short Test for Assessing Deficits of Memory and Attention. Int Psychogeriatr. 1997;9(2):139-153. https://doi.org/10.1017/s1041610297004304
Cummings J. The Neuropsychiatric Inventory: Assessing psychopathology in dementia patients. Neurology. 1997;48(5, suppl 6):10-16. https://doi.org/10.1212/wnl.48.5_suppl_6.10s
Jacelon C. The Barthel Index and Other Indices of Functional Ability. Rehabilitation Nursing. 1986;11(4):9-11. https://doi.org/10.1002/j.2048-7940.1986.tb00995.x
Goetz C, Stebbins G, Chmura T, Fahn S, Poewe W, Tanner C. Teaching program for the movement disorder society-sponsored revision of the Unified Parkinson’s Disease Rating Scale: (MDS-UPDRS). Mov Disord. 2010;25(9):1190-1194. https://doi.org/10.1002/mds.23096
Emre M, Tsolaki M, Bonuccelli U, Destée A, Tolosa E, Kutzelnigg A, Ceballos-Baumann A, Zdravkovic S, Bladström A, Jones R. Memantine for patients with Parkinson’s disease dementia or dementia with Lewy bodies: a randomised, double-blind, placebo-controlled trial. The Lancet Neurology. 2010;9(10):969-977. https://doi.org/10.1016/s1474-4422(10)70194-0
Aarsland D, Ballard C, Walker Z, Bostrom F, Alves G, Kossakowski K, Leroi I, Pozo-Rodriguez F, Minthon L, Londos E. Memantine in patients with Parkinson’s disease dementia or dementia with Lewy bodies: a double-blind, placebo-controlled, multicentre trial. The Lancet Neurology. 2009;8(7):613-618. https://doi.org/10.1016/s1474-4422(09)70146-2
Wesnes K, Aarsland D, Ballard C, Londos E.. Memantine improves attention and verbal episodic memory in Parkinson’s disease dementia and dementia with Lewy bodies: A double-blind, placebo-controlled multicentre trial. Alzheimer’s & Dementia. 2013;9(4):890. https://doi.org/10.1016/j.jalz.2013.08.252