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Okovityi S.V.

Saint-Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Shustov E.B.

Institute of Toxicology FMBA of Russia

Ornitine-dependent mechanisms of muscle fatigue correction and recovery from physical activity

Authors:

Okovityi S.V., Shustov E.B.

More about the authors

Journal: Problems of Balneology, Physiotherapy and Exercise Therapy. 2020;97(4): 74‑83

DOI: 10.17116/kurort20209704174

Views: 15520

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To cite this article:

Okovityi SV, Shustov EB. Ornitine-dependent mechanisms of muscle fatigue correction and recovery from physical activity. Problems of Balneology, Physiotherapy and Exercise Therapy. 2020;97(4):74‑83. (In Russ.)
https://doi.org/10.17116/kurort20209704174

Подписка 2025 (Problems of Balneology, Physiotherapy and Exercise Therapy)
 
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The article analyzes the literature data characterizing modern concepts of the mechanisms of muscle fatigue and metabolic features of recovery processes after exhausting loads. The significance of transient hyperammonium in the formation of the developed complex of fatigue manifestations in the central and peripheral links of motor units, its pathogenetic links with oxygen debt, lactacidosis, violation of ATP resynthesis, deficiency of energy-supplying substrates in working skeletal muscles, damage to muscle fibre structures, and dysfunction of various parts of the CNS is shown. The necessity of correction of hyperammoniemia associated with physical activity has been confirmed to reduce the speed of formation and expression of fatigue feeling, to reduce the risks of development of fatigue and overtraining states in sportsmen and to ensure effective course of recovery processes after exhausting physical activity. It was revealed that ornithine-containing preparations can be used for correction of post-load hyperammonium and acceleration of recovery processes. The data characterizing the high efficiency of L-ornitine-L-aspartate in sports medicine practice are presented.

Keywords:

physical fatigue
hyperammonium
post-load recovery
ornithine

Authors:

Okovityi S.V.

Saint-Petersburg State Chemical and Pharmaceutical University of the Ministry of Health of Russia

Shustov E.B.

Institute of Toxicology FMBA of Russia

Received:

20.05.2020

Accepted:

25.05.2020

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